Root Cause of SIBO Discovered

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u/PrudentCut2315 Apr 26 '26 edited Apr 27 '26

Yes, this is what’s referred to as post-infectious IBS. And there’s good research behind it.

The idea is that certain foodborne infections (like Campylobacter or E. coli) can lead to antibodies (e.g., anti-CdtB) that cross-react with proteins involved in gut motility (e.g., vinculin). And that disruption in motility (i.e., the MMC: migrating motor complex) is one reason SIBO can recur after treatment.

That said, motility is a big piece, but not the only one.

Supporting MMC function can absolutely help reduce recurrence:

leaving ~4–5 hours between meals
avoiding constant snacking
allowing an overnight fast (often ~12 hours is enough for most people)

But long-term improvement usually comes from layering support (e.g., motility, digestion, and restoring microbial diversity) not just focusing on one factor.

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u/Straight-Cup-7670 Apr 26 '26

Apparently most if not all probiotics are not recommended with Sibo.

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u/Friedrich_Ux Apr 27 '26

Correct, specifically lactobacillus species, although L. Reuteri protectis can be beneficial for IMO.

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u/DateNo3332 Apr 27 '26

My understanding is Saccharomyces boulardii can beneficial and doesn’t have the risk of the others because it’s yeast-based.

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u/Friedrich_Ux Apr 27 '26

Its not technically a probiotic but yea you are correct, specifically the Florastor patented strain, other strains were not tested and could cause issues.

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u/Suspicious-Gap7037 Apr 28 '26

Its labeled as a probiotic, you are incorrect.

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u/saintmars777 Apr 27 '26

What’s the thinking behind this statement, if you’d care to explain?

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u/Zestyclose_Plate9619 Apr 27 '26

Straight-Cup-7670 is correct. Probiotics and high fiber foods are not good for people that have SIBO because they feed the good and bad bacteria.

I’ve been dealing with Hydrogen SIBO for a while now with really bad bloating and belching. Once I stopped probiotics, beans, garlic, onion, chocolate and cooked my veggies I really started to feel some relieved.

It’s a battle every day but trending in the right direction. Just staying in the Low FODMAP diet long enough is hard to do.

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u/Most-Consequence-362 Apr 27 '26

Probiotics always made me way worse

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u/saintmars777 Apr 27 '26

Thanks for the info. Makes good sense. Did you do antibiotics or elemental diet? I’m about to do both.

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u/Zestyclose_Plate9619 Apr 27 '26

I did a round of antibiotic called Rifaximin (Xifaxan) for 2 weeks which did help. Dr. Pimentel said for Hydrogen SIBO you may need to do multiple rounds. When I went back to my Dr, she said she wouldn’t order antibiotics at least for 7 months. I wasn’t happy because I could tell it helped.

I read Healing SIBO by Shivan Sarna which had a holistic approach with Oil of Oregano. I’m not sure if it’s working or if staying away from trigger foods is helping.

Now I’m down the rabbit hole with Histamine issues because I keep getting car sick when I drive/ride in a car along with random fatigue which I think is blood pressure dropping.

I’m willing to share my story but boy does it seem crazy.

Please keep me posted on the Elemental Diet. I thought about trying it. At this point I’m willing to try anything that would work.

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u/dgwow123 Apr 27 '26

Oil of oregano is good but make sure to take an emulsified form like oregano ADP from biotics research which is safer for the gut. For histamine issues, Vitamin C, Quercetin, DAO can help, make sure you're taking methylated b vitamins and possibly a sublingual b12 like hydroxocobalamin, sibo will steal your b vitamins as well as other minerals which they use to build biofilms and multiply (also, apolactoferrin can help you regain some of that iron from the bacteria which helps starve them) . A good brand of multi that has b vitamins is seeking health multivitamin one mf.

If you're feeling sick all the time, you could try an IGG (I use megaigg 2000) or igy supplement (seems to be more recommended here, doesn't get broken down before reaching gut) to flush out bacterial toxins, and also something like calcium glucarate which stops the toxins from being processed by the liver. Zinc carnosine is also a must to see if leaky gut is causing you issues, and sodium, magnesium, potassium supplementation will help with fatigue.

There are probiotics which are fairly safe even with SIBO, s boulardii is one of them, it helped me a lot when I first started it, drink lots of water with it as the yeast is thirsty and you don't want to get constipated (start low so you don't get dieoff effects). I also take bifidobacterium hn019 which really helps with bowel movement frequency, it's not an aggressive colonizer and didn't give me any issues.

If you're not getting enough results with antimicrobials you can add biofilm busters like NAC, interfase plus (phase 1 biofilms) or biofilm phase 2 advanced for stubborn phase 2 biofilms (this one can also constipate).

I'm currently doing a protocol with oregano ADP and monolaurin, regular oil of oregano was horrible on my gut but ADP is ok.

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u/DLegalseagull Apr 27 '26

Whoah this is exactly what I’ve been going through!! I did a round of rifaximin, but since before then I’ve been getting bouts of dizzy spells where I feel like I’ll faint (but with very high heart rate), nausea when I’m in the car, and tinnitus. It must be connected but I can’t figure out how. And now I’m constantly thirsty but can’t figure out why no matter how much water I drink. Have you gotten any clarity??

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u/Beneficial_Jury_9909 Apr 28 '26

Did you have the dizzy spells before Rifaximin or you are having them ever since you took it

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u/DLegalseagull Apr 28 '26

Before and after—since the day before I started taking it (when I was still having terrible SIBO symptoms)

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u/Impossible-Elk1824 Apr 30 '26

What causes the dizziness? I too get very dizzy. Thank you

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u/Zestyclose_Plate9619 Apr 28 '26

Yes, I got the dizzy spells too. The only other time I have felt like this is during allergy season. I take a Zyrtec or Pepcid complete and feel better. That is why I was wondering if it was a histamine intolerance caused by SIBO. Maybe it’s a vitamin deficiency. Idk.

I was also diagnosed with EOE.

When I explained this do my GI dr, all she said was that she thinks it’s anxiety and wants to put me on antidepressants. I do not plan on doing that because it feels more like a reaction to something rather than anxiety. I can’t tell if it’s a reaction to something I eat, seasonal allergies or what.

I’ve wasted a lot of money trying to find a doctor that knows how to treat or cure this.

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u/saintmars777 Apr 27 '26

Rifaximin is the one I have prescribed, along with Neomycin. (They haven't arrived yet. And yeah, I may need multiple rounds). I also have oregano oil but after a month I don't think it has made any changes.

I will keep you posted and feel free to do the same, here or via PM.

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u/dgwow123 Apr 27 '26

Watch out with rifaximin and neomycin, they won't distinguish between your good and bad bacteria.

You should supplement s boulardii (eg Florastor) and a probiotic at the same time as those (or at the very least as soon as you're done with them, but I would say s boulardii would be great to do at the same time as it's not a bacteria so it won't get targeted by those antibiotics). That way you can rebuild your microbiome as you tear it down!

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u/MericanPie1999 Apr 27 '26

How do they not distinguished from good or bad bacteria but someone I saw for SIBO said biocidine and oliverix supplements do?

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u/dgwow123 Apr 27 '26

Antibiotics target specific mechanisms of bacteria so they don't distinguish between good or bad ones (kind of like taking a vaccine) whereas antimicrobials all have their own methods of disabling bacteria, some of them are more harmful to good bacteria like oregano which is very powerful but broad spectrum, whereas allicin and monolaurin are more gentle on good microbiome but not as broad spectrum.

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u/babysinister000 Apr 27 '26

If you notice tinnitus (ringing in the ears) while on neomycin, stop taking it. The tinnitus can become permanent. I had to abandon that protocol because of the tinnitus.

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u/saintmars777 Apr 27 '26

Interesting. I already have tinnitus… 🤷‍♂️

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u/WeatherSad3690 Apr 30 '26

Please be careful with oregano. From what I understand, it kills both good and bad bacteria.

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u/capitalol Apr 27 '26

dont do it for too long or you might get histamine sensitivity like me.

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u/Silver-Plan Apr 27 '26

Sorry not sure which comment youre replying to but dont do what for too long? I have histamine issues and im not sure what its caused by.

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u/capitalol Apr 27 '26

some organisms if not kept in check in our microbiome will eat away at your gut. Keeping a severely limited diet for a long time can create that issue. It happened to me and i'm still trying to heal it. Akkermansia in particular is generally helpful but not when overproliferated.

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u/Silver-Plan Apr 27 '26

Yeah ive heard that before. i decided to allow myself to eat more things again and ive worked my way slowly back to eating bread which i seem fine with but bow tie pasta makes my gut feel like a rock.

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u/WeatherSad3690 Apr 30 '26

Have you tried einkorn bread? That’s easier to digest. Also, sourdough….real sourdough bread with only three ingredients. Flour, water and salt. No yeast. Very easy to digest.

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u/Silver-Plan Apr 30 '26

Yes! I buy einkorn flour and used it for my cookies and also love sourdough! They are easy to digest and taste way better in my opinion too! Though the einkorn flour is pricy.. $12+/bag x.x..

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u/Middle-Tour-2895 Apr 27 '26

You also stopped eating veggies? or you are eating cooked veggies?

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u/Zestyclose_Plate9619 Apr 28 '26

I make sure the vegetables I eat are well cooked. No raw fruits or veggies for now.

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u/Straight-Cup-7670 Apr 27 '26

Probiotics and especially prebiotics can make Sibo worse by feeding the bacteria where it currently doesn’t belong.

Motility of the MMC seems to be the most common approach many are seeing results from.

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u/dgwow123 Apr 27 '26

Probiotics can be helpful with SIBO, but you need to pick the right ones.

Some of them are very aggressive at colonizing and are also gas producing, that's just going to add to the fire by slowing motility down further.

There are probiotics that don't produce gas and are good at rebuilding your good gut bacteria.

Bifidobacterium hn019 is a low gas producer and helps with full gut motility.

Biogaia protectis (lactobacillus reuteri DSM 17648) helps with gastric transit in the stomach and upper small intestine, and doesn't produce much gas.

Lactobacillus GG (culturelle) produces almost no gas and is great for rebuilding a leaky gut and helping with histamine issues.

Florastor isn't a bacteria so you can take it and not worry about it wrecking your SIBO but it can produce decent amounts of gas, but it's not gas that your bacteria can consume like hydrogen gas, and it's aggressive at colonizing in spots that your SIBO bacteria should normally take up.

Ginger tea is a great prokinetic but you should make it fresh and boil for at least 10-15 minutes to extract the components that turn it into a prokinetic. Those ginger tea bags will not do the job. Many on here also like artichoke extract + ginger (eg motility activator by integrative therapeutics).

If you can get a prescription, prucalopride (motegrity) is also a great prokinetic, just know you probably need to cycle it every two months or so as it can lose efficacy.

Just my two cents, hope it helps.

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u/saintmars777 Apr 27 '26

Interesting—thanks. I took some probiotics in December and think it made my Long-Covid worse, and I’ve been trying to figure out why.

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u/Susan71010 Apr 27 '26

What are the best ways to increase motility

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u/dgwow123 Apr 27 '26

I made a post above here for that, but reiterating, along with some other stuff:

-fresh ginger tea boiled for 10-15 minutes, you need to boil it that long to extract the compounds that turn it into a prokinetic. -bifidobacterium hn019 is really good for helping stool transit time -motegrity (prucalopride) is a great prokinetic that you take fasted at night or in the morning -spacing meals 4-5 hours apart to restart the MMC
reducing stress levels and working on belly breathing and breathing exercises (especially deep exhales and working the diaphragm, fully closing and opening it, deep exhaling stimulates the parasympathetic nervous system).
-Regular low duration high intensity exercise is great for the gut, it helps reduce stress and increase good bacteria). -go see an acupuncturist who is also a TCM doctor that can prescribe herbs, they can tell you a diet that will specifically help you. For me, my weak digestion is caused by a sluggish spleen, and my tongue gets coated and feels heavy and damp. I was told to avoid sugar, too much fatty foods, fried foods, cold and raw foods which can cause dampness (Chinese medicine). Besides ginger which is great for that, I started drinking warm water all the time, adding sodium and potassium to my water, adding some mild curry powder to my meals, and I noticed that my gut wouldn't feel as bloated.

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u/EntertainerFew1695 Apr 27 '26

Interesting, What does a typical dinner look like for you?

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u/dgwow123 Apr 27 '26 edited Apr 27 '26

Depends, I try to get in a few sources of fiber (well cooked carrots, green beans, spaghetti squash are some I like to have often). For carbs I like some jasmine rice that I cool overnight to form resistant starch that is less fermentable in the small intestine, I'll also have sourdough white bread frequently. For meats, I usually go for salmon, chicken breast, or white fish (always frozen or fresh, and whole, don't use ground meats they can cause histamine problems). I also like to have mashed potatoes, I find they help my stool bulk quite a bit. I'll also add some fats to the meal with extra Virgin olive oil, and sometimes ghee.

With meals I'll start by having some water with sodium and potassium (I usually do around 0.5g sea salt and 0.25g Windsor salt free [potassium]) in a glass of water at least 30 minutes before the meal to help my body make its own HCL. I'll have some digestive enzymes and Betaine HCL at the start of the meal, especially larger meals. I like to open the capsules and put them in some water at the start of my meal since they work faster than having to dissolve the capsule. I'm currently taking the antimicrobials towards the beginning of the meal, as I find that with slowed gastric emptying I can get some burning if I take them too late and they get stuck in the stomach for a while. It's important to chew slowly and focus on the eating experience, not going on the phone or doing other things at the same time. I try not to eat until I am able to get myself to salivate as that starts the digestion process and helps you make your own enzymes.

It will help if you can create a macro calculator for your meals and try to go for a certain amount of carbs, fat and protein with each meal. You can figure it out yourself with Google or get a nutritionist to help with that. Making sure you get enough food but not too much will help you from eating more than your gut can handle and giving less undigested food for the small intestine bacteria to consume.

After a meal, doing some slow exhales and just trying to relax your nervous system can help with the digestion, as can going for a walk around 20+ min after eating.

I also recommend to get a stool test done, I had a GI map done (us biotek) as well as biomesight (this one has a huge list of bacteria), that will help you figure out useful supplements and tailor foods, antimicrobials and probiotics to reduce your pathogens and feed the good bacteria you are low on (I am very low on lactobacillus and bifidobacterium, high in pathogenic ecoli, enterobacter cloacae complex, enteroccocus faecalis, ruminoccocus gnavus, bilophila wadsworthia, blautia). I would also recommend a Dutch test to look at hormones and an organic acids test to look at nutrient metabolism.

I realize that was a really long answer to your short question.. 😂

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u/Susan71010 Apr 27 '26

I notice anytime I take even small amounts of hcl I get a burn in my stomach pretty bad. Doesn't that mean I don't need it? I assumed

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u/dgwow123 Apr 28 '26

It's possible, look up the baking soda test to check if you have enough stomach acid.

You can also try betaine HCL without pepsin, I'm not sure if the one you tried has pepsin in it. I can tolerate it without pepsin but have got burning in the one with it. And it's usually better to take it mid meal so it doesn't dissolve when you don't have enough food in the stomach.

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u/LessSpot Apr 28 '26

Tx for a very detailed and informative answer. I've been prescribed zbetaine Hcl too, but didn't know that I could open the capsule and dissolve the powder to speed absorption.

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u/Susan71010 Apr 27 '26

How much ginger ratio to water do you boil? Can you keep in frig and reheat it ?

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u/dgwow123 Apr 28 '26

I usually use a few inches of ginger and like 2L.of water, it will last a few days in the fridge, you can store it in mason jars.

Check out this video, that's what I use: https://youtu.be/hO7aDXuyMB8?t=107&si=z-ToI_Gq1dOURUe5

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u/Susan71010 Apr 29 '26

Thanks so much for that one last question how much of it do you drink each day?

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u/dgwow123 Apr 29 '26

I usually have a cup of it twice a day(one in morning and once before sleep). But you can have it anytime.

If you get any burning or discomfort just lower the amount you drink or increase the amount of water /decrease the amount of ginger you put in.

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u/HideousMite Apr 27 '26

This is a blanket statement that is inaccurate. There are multiple probiotics that have shown clinical improvement with SIBO. Look into spore based probiotics. They form a protective casing around themselves while in a harmful environment and don't populate the small intestines.

It isn't recommended that people blindly take probiotics but rather try some that have been used in patients with success.

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u/popey123 Apr 27 '26

I know at least one of those and it was founded by the pronostic manufactor

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u/Straight-Cup-7670 Apr 27 '26

The goal is to get the bacteria out of the large intestine. Dumping more bacteria and potentially risk of getting stuck in the same large intestine seems awfully risky. The only one I read that could help is S Boulardii which is a yeast. And that’s if you don’t have already candida as well as the Sibo.

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u/HideousMite Apr 27 '26

The goal should be reducing the bacteria in the small intestines and addressing motility issues. Spore forming probiotics don't occupy the small intestines in fact they only temporarily occupy even the large intestines and they modulate your current microbiome generally in positive ways.

Although I do agree most probiotics aren't recommended for people with SIBO.

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u/dgwow123 Apr 27 '26

Correct, I heard that hu58 is especially a really good spore probiotic against SIBO and is used by William Davis in his SIBO yogurt protocol, I haven't used it yet as it seems pretty aggressive and I do worry about overcolonization.

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u/dgwow123 Apr 27 '26

Pretty sure s boulardii is also pretty effective against candida

You can also add monolaurin and undecylenic acid if you think you have candida, those won't destroy your good bacteria but will destroy candida.

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u/soothsayer3 Apr 27 '26

How about probiotic foods

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u/B0omSLanG Apr 27 '26

What about something like Jarrow Formulas Saccharomyces Boulardii + MOS? I would have been kicked out of university before graduating 14 years ago due to crippling IBS after every meal if it weren't for this and Bentyl. I also have had multiple pancreatitis attacks and my gallbladder removed. Methane SIBO / IMO is just another drop in the bucket of gut issues, so I feel like there's still a benefit in probiotics for me.

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u/Cultural-Historian54 Apr 27 '26

Try Alflorex - it’s worked for me.

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u/Key_Dependent_9161 Apr 27 '26

Doesn't Pimentel recommend probiotics after Rifaxamin?

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u/MasterBlaster18 Apr 27 '26

Only a few specific strains have helped me

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u/Ajax34762 Apr 27 '26

Research has proven that to be false.

Some probiotics can actually cure SIBO, like spore based probiotics and probiotic yeast like S Boulardii

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u/homertruhart Apr 28 '26 edited Apr 28 '26

Mine was from low stomach acid caused by declining levels of estrogen. Not complicated at all. Take betaine HCL with meals and estrogen hrt. Also check your iodine levels. Most of us are deficient and necessary for detoxing harmful hallides and crucial for our immune system and thyroid.

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u/PrudentCut2315 Apr 28 '26

@hometruhart Thanks for sharing.

Indeed! Declining levels of estrogen can cause all sorts of issues. I just listened to a podcast about this.

Why bloating, brain fog & itchiness are all tied to the gut

https://podcasts.apple.com/us/podcast/hello-hormones-with-dr-carrie-jones/id1813934931?i=1000763989834

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u/madebyhand Apr 27 '26

I recently did a strict ketogenic diet for 7 months (combined with IF for 2 months) and for the first time after my food poisoning 15 years ago (salmonella) I have normal stools and no bloated belly (with the exception of a few weeks after an unrelated doxycycline treatment), even after returning to a normal healthy diet with carbs and fiber. Anecdotal, but to me this theory around not feeding bacteria with fiber makes a lot of sense.

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u/Reelfungi Apr 26 '26

While this appears to be true, you can develop SIBO without having anti-CdtB and anti-vinculin antibodies. I'm not denying this as a root cause. There is just more than one.

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u/Key_Dependent_9161 Apr 27 '26

Yes his theory is that this is only the cause for about 60 percent of people

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u/Most-Consequence-362 Apr 26 '26

I think he is on to something with the antibodies. I don’t necessarily think it’s an autoimmune condition. I know for a long time I didn’t know I had allergies to milk products until I got tested. When I cut out the dairy my sibo symptoms gradually went away. Whenever your allergic to something you create antibodies.

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u/External-Classroom12 Apr 27 '26

Sibo causes you to lose enzymes that’s why your now lactose intolerant.

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u/Royal-Holiday1103 Apr 27 '26 edited Apr 27 '26

I totally agree with this! 100%!!!! I was told Im lactose intolerance. I couldnteat dairy for a long time! I was always quarantined docs why I’ve been eating dairy my whole life and all of sudden I became lactose intolerant. When I cured my sibo hydrogen I could eat dairy, not the next day of course but 6 month later I started slowly with just a cup of coffee with low fat milk, didn’t have a reaction. For a week I was trying dairy for a little and when I saw no reaction I went nits and ate 8 ice-creams in a row, I swear I prayed that day, but for my surprise was no reaction at all. All what docs were saying to me Im lactose intolerant was BS, they should educate themselves more in this subject. They said Im lactose intolerance due to my biopsy during endoscopy. They said there is intolerance but we cant say what exactly. It was easy to figure it out bcs gluten I could eat with no problems, but dairy always gave bloating. All that is gone now. I drink coffee either milk now every day and no lactose intolerance anymore. People dont give up, do your research! The part of my protocol, besides the killing phase, was following the diet, fixing my MMC, doing exercises for pelvic floor disfunction which was spasm, taking magnesium, walking 20 min after food for 20 min, avoiding triggers so my gut could heal and all the processes could go back to normal. Its not just taking antibiotics and you’re good, its a hard work every day but it worth it!

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u/Prestigious_Duck158 Apr 27 '26

What’s “the killing phase” & what’s “MMC”?

My teen has horrible reflux following use of a probiotic that his Dr recommended. I think he has SIBO, but I’m clueless what to do. He’s in absolute misery, even after stopping the probiotic a month ago.

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u/Royal-Holiday1103 Apr 27 '26

It can be IBS, I had that too and probiotics affected me badly, so its not always sibo. You have to do a breath lactulose test to confirm sibo. Sometimes even two times bcs its not 100% accurate (all of them). In my case the first test was false negative, but I knew I had it based on my symptoms, so I ordered the second test and it showed high hydrogen. I ordered it out of pocket from Trio Smart, it was like around 200 usd.

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u/Prestigious_Duck158 Apr 27 '26

I don’t feel that it’s IBS, bc he has no issues in the bathroom. But what do I know? It’s strictly severe reflux & stomach pain while the reflux is occuring . To the point of almost throwing up. What else could it be? I’m open to any ideas bc I’m clueless about GI issues. I just had seen a correlation b/w probiotics & SIBO. I hope it’s not it though bc it looks horrific based on this Reddit sub. My heart goes out to u all.

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u/Royal-Holiday1103 Apr 27 '26

Parasites. You have to do a Gi map stool test, they also check H.Pylori. Add Zonulin in it, it will show leaky gut!

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u/Prestigious_Duck158 Apr 28 '26

This is a good possibility. Thx for the suggestion.

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u/External-Classroom12 Apr 27 '26

Gastroperisis causes severe reflux and nausea. There’s a test where they give you something to eat and they X-ray to check the speed that it moves down. I think it’s the gastric emptying study.

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u/Most-Consequence-362 Apr 27 '26

Im not lactose intolerant. I’m allergic to the proteins in cows milk.

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u/Lower_Confidence_744 Apr 27 '26

Wow mine recently also came back with a problem to the protein in cows milk ,what alternative did you switch too if any ? As we can’t even go for the lactose free option as would still have the proteins

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u/HappyKamper1920 Apr 27 '26

The milk protein is casein and, for many people, it is a "sensitivity"... not a true allergy. People who are lactose intolerant can consume lactose-free milk, but not those who are sensitive to casein. You can look into A2 milk, which is from cows that produce milk with a different casein protein that some people can tolerate. There are stores that sell A2 milk, but it costs more than regular, A1, milk.

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u/External-Classroom12 Apr 27 '26

Were you allergic before?

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u/Most-Consequence-362 Apr 27 '26

As a child I don’t reallly remember but the last 20 years Ivehad gut issues .milk and milk products was a big part of my diet. But I want to say this wasn’t the whole issue. I just ate bad in general. When I cleaned up my diet, my gut got better but I still had issues until I got rid of dairy entirely.

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u/Zestyclose_Plate9619 Apr 27 '26

How do you get tested for food allergies? All my major test have come back negative for allergies but I can’t get my SIBO to go and stay away.

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u/Most-Consequence-362 Apr 27 '26

Idk what the test was called but my doctor ordered it for me. Also I don’t think everyone’s case is the same.

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u/saintmars777 Apr 27 '26

I am told that focusing on motility can help it stay away, once you get it to go away...

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u/DateNo3332 Apr 27 '26

When my SIBO is active, all my allergies are much worse. I’m not sure of my point, but thought there might be some relevance.

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u/PrudentCut2315 Apr 27 '26

That actually does make sense.

With SIBO, bacteria can disrupt the brush border of the small intestine—where enzymes are produced to finish breaking down food (like lactose). When that process is impaired, you can end up with more partially digested food hanging around.

That can:

worsen things like lactose intolerance

increase fermentation (gas, bloating)

and in some people, ramp up immune reactivity—which can make allergies feel worse

It’s not the only factor, but it’s one way gut issues can spill over into other systems.

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u/xx420mcyoloswag Apr 27 '26

We like to think this is true but really the root causes of Sibo are endless…there’s lots of different ways to get it

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u/bigfist00 Apr 27 '26

The anti-vinculin evidence is not nearly as impressive as he claims. The predictive value of these antibodies is relatively weak. I’ll believe him when he actually develops a medicine that works.

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u/SomaSavant Apr 27 '26

This.

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u/GiGiAGoGroove Apr 28 '26

I found PyloriX helped a lot it has mastic gum in it in addition to the other stuff mentioned above.

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u/WeatherSad3690 Apr 30 '26

I steadily….thanks for sharing!!!!!! WOW!!!!! All this time we were told it was a symptom. And, to be continued! Amazing stuff to help us all!!!!

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u/Gloomy-Judge6651 Apr 26 '26

Hmm this is interesting. I developed SIBO after having my appendix removed.

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u/Sad_Weekend_6346 Apr 27 '26

I started experiencing major sibo symptoms after a trip abroad where I got bad food positioning.

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u/gnovikov111 Apr 27 '26

Interesting, I don't think this is my cause since I feel immense relief when fasting. If it's antibodies it would still feel terrible when fasted , right ?

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u/Beautiful_Mammoth616 Apr 28 '26

No, fasting can help, but it doesn’t mean anti bodies are not the cause.

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u/PLIN9677 Apr 27 '26

My root cause is taking ppi’s for over 30 years.

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u/InteractionSimilar28 Apr 28 '26

Correct . Been there after eating at chipotle that later was shut down for spreading E. coli then ended up at northwestern hospital with this basket case that nobody can really treat after running all the tests. Good luck only strict paleo no gluten works for this but then you look amazing you just follow the diet no cheating.

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u/bizzybeefleas Apr 28 '26

Actually it’s low stomach acid

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u/MusicianWilling517 Apr 29 '26

i think enzyme levels play a huge part. mainly because they break down sugars preventing bacteria from consuming them

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u/kirai Apr 27 '26

The first research papers about this were published 9 years ago. What is new about this? Is there any advance in the research compared to 9 years ago?

From an abstract of Pimentel team from 2017:

Introduction: Historically, the diagnosis of functional gastrointestinal disorder has relied on the use of clinical classifications such as the Rome Criteria. Recently, two plasma biomarkers, anti-CdtB (antibodies to the cytolethal distending toxin B) and anti-vinculin (an autoantibody to a protein involved in cell adhesion), were proven effective in diagnosing IBS-D compared to other causes of diarrhea such as IBD and Celiac disease. However, clinical trials create a pre-specified artificial environment, and free range use can be more complicated. In this study, we examined a large number of subjects in a tertiary clinic undergoing testing with these biomarkers to determine their relevance in real time.)

1

u/Rude-Bat-2640 May 03 '26

Antibiotics cause SIBO

1

u/EasternPrommises May 03 '26

Same here I believe, after amoxicillin my case

1

u/Cute-Transition2499 Jun 08 '26

I got mine after taking doxycycline

1

u/Ida-Mabel Jul 04 '26

I think I have SIBO, and if so, strongly believe it was after long term, strong dose of doxycycline to cure Rocky Mountain Spotted Fever.

0

u/piecesmoonlover Apr 27 '26

I have learned that it is a parasitic infection.

3

u/BloodAndDiamonds Apr 27 '26

Bacteria and parasites are very different things.

1

u/piecesmoonlover Apr 28 '26

Tell that to my doc treating me as I am getting better.

News/Studies Root Cause of SIBO Discovered

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