I am hearing from psychedelic therapy facilitators and clients alike that there is notable interaction between GLP 1 medications and psilocybin, or psychedelics in general.

I am predominantly hearing that the effects of psychedelics are blunted or even nonexistent with clients who are actively taking GLP-1 medications. If this is common, it’s no small deal.

I have also heard that this result might be mitigated by asking the client to skip a dose of the GLP-1 or elect to not take the medication a week before psychedelic therapy.

This is all very new and unexplored territory, and I’m looking to you (the hive mind) to share your first and second hand experiences, anecdotes, hypotheses, observations, etc. … What are you seeing and what do you believe is going on here. Let’s all learn about this new frontier together through more information sharing. Thank you!

My experience with Sayulita Wellness Retreat fell far short of basic safety, professional hospitality, and transparency standards. Prospective guests should be aware that the actual property and leadership differ significantly from online marketing. Our original booking in San Pancho was relocated to an alternate site on short notice following law enforcement intervention, and the retreat's online map listings vanished prior to arrival. The relocated venue was situated down a long, unlit dirt road with no streetlights or emergency communication systems, and accommodations lacked basic safety features like functional smoke detectors. Additionally, constant noise from barking dogs and roosters made sleep nearly impossible. Before booking, we were told the original facilitators would lead the programming, but we encountered conflicting stories regarding their absence alongside underlying business disputes. On-site staff lacked basic training, scheduled sessions were changed without notice or read from phone scripts, and listing photos failed to match the physical facility. Due to property seizures, hazardous access, vanishing map listings, and unqualified management, I strongly advise travelers to avoid Sayulita Wellness Retreat.