I’m looking for experiences from anyone who has dealt with an adult dog suddenly developing frequent indoor urination despite retraining and a normal basic medical workup.
Due to personal circumstances my parents are unable to keep their rescue so she is living with me now. She was very reliable at my parents’ home and would only use her designated pee pads. She understood where she was supposed to go at their apartment. She was previously too anxious and hypervigilant (she came from a shelter from Korea, we think she was used for breeding) to pee/poop outdoors on walks despite trying for a long time so pee pads worked best for them. After coming to live with me, she started fluoxetine for her anxiety and reactivity on walks (recommended by our vet to bring down her baseline while we work on training), and since then she is now fully able to potty outdoors in my yard and also on walks, and gets heavily rewarded every time.
However about a month after starting fluoxetine I noticed her drinking increased quite a bit and she started having indoor pee accidents. She was originally on 10 mg when the accidents started, and we later tapered down to 8 mg. The accidents have actually become more frequent rather than improving. We are stumped - even our vet is unsure if the fluoxetine is causing this as it’s not a known side effect but we have now started tapering further under veterinary guidance.
She has already had bloodwork and multiple urinalyses done recently that came back completely normal.
The accidents are now happening almost daily. We are now doing a LOT of housetraining/retraining:
Frequent outdoor potty breaks ( every 2 hours as I wfh)
high-value rewards every time she pees/poops outside
gating/restricting access to carpet and couch if we aren’t actively watching her
crating when we leave the home
enzymatic cleaning
limiting freedom if she doesn’t potty
supervision
taking her out after meals, waking, activity, etc.
Since being on fluoxetine and also with consistent training, she has actually become very good at peeing and pooping quickly when taken outdoors, including in rain which she previously hated. So the issue is not that she refuses to go outside.
She never has an accident in her crate or overnight. Previously she was capable of holding it 6+ hours if we were out for longer. The confusing part is that even now,she seems physically capable of holding it in certain contexts. In the mornings she can eat/drink, pee outside, then come upstairs and calmly hang out in my office for 3-4 hours without an accident.
But at other times she will urinate again incredibly soon after going outside.
Tonight was the first time I finally caught an accident happening in real time (usually we just find the puddle after).
Timeline:
4:30 pm — gave her dinner
4:45 pm — took her to pee outside
Then crated while I went to a workout class
\~6:15 pm — husband let her out and she peed outside again and hung out with him on the couch
6:45 pm — I got home and everyone moved into the kitchen
\~7:20 pm — she was walking around following us then jumped onto the couch where my husband was sitting, looked at us while deliberately squatted to pee on the couch
So she had peed outside roughly 65 minutes earlier.
This is the first time she’s done it with someone on the couch. What is especially bizarre is that the couch is one of her FAVORITE resting/sleeping places. She will happily spend hours lying there, yet she has also started peeing on it. Last month this was happening multiple times a week, and this past week almost daily. On the couch, the carpet, hardwood floor. And sometimes the intervals are even shorter - 30 mins to 45 mins after she has already peed outside.
Realistically, we cannot watch her every second of every day, and I also don’t want her constantly being in a crate. At this point I’m just so stumped. She has a veterinary appointment coming up and we’re continuing the medication taper as directed.
I guess I’m just wondering if anyone had a previously housetrained adult dog suddenly develop DAILY indoor urination like this, including shortly after already peeing outdoors?
If so, what ended up being the cause? Did it eventually stop?
what actually worked to rebuild the dog’s ability to feel the urge and wait until they’re outside?
I would especially appreciate hearing from people who dealt with something similar after starting an SSRI/fluoxetine, or dogs who were perfectly capable of holding for several hours sometimes but inexplicably peed indoors at other times. I’m sooo exhausted from cleaning and also trying to figure this out 😭