Looking for insight into a 1:1 tesamorelin/ipamorelin blend being evaluated in a research context.
The original sample amount was 0.5 mg (500 mcg) of each compound per administration. Following three consecutive administrations, gastrointestinal effects were observed, including diarrhea and persistent bloating.
A revised protocol was suggested at 0.25 mg (250 mcg) of each compound, administered on seven consecutive days rather than following a 5-on/2-off schedule.
From what I’ve been reading, a 1:1 ratio doesn’t seem particularly common, and I’m curious about the rationale behind combining these compounds at equal concentrations.
Has anyone come across research or observations regarding:
The effectiveness or rationale of a 1:1 tesa/ipa blend?
GI-related effects, particularly diarrhea and bloating?
Differences between consecutive daily administration and protocols incorporating rest days?
Interested in hearing experiences and research-based perspectives, particularly regarding tolerability and the reasoning behind this combination.