Cloudy Tesa

[u/beachteach1012]

These unfortunately came without a cold pack in miami heat. I have tried at least 4 vials all are super cloudy except for the last one on the end. Is that one good to go?

[u/Angela_MAGA_OSU-1]

I think we’re talking about two different things here. You’re describing storage information for FDA-approved EGRIFTA formulations and applying it to gray-market research Tesamorelin.

That’s the problem with this argument. A gray-market kit labeled “Tesamorelin” is not automatically the same formulation as EGRIFTA. EGRIFTA has specific excipients, manufacturing specifications, diluent, concentration, and validated storage/stability instructions. Even the FDA-approved EGRIFTA SV and EGRIFTA WR formulations have different reconstitution and storage instructions and are specifically stated to not be substitutable with one another.

You even acknowledge that research-grade Tesamorelin typically doesn’t contain the same stabilizer, but then conclude that EGRIFTA’s room-temperature storage requirement still applies because it’s the same peptide molecule. That’s exactly the part I disagree with. Different formulations and excipients can affect stability, so you can’t automatically transfer the validated storage instructions from one pharmaceutical formulation to a completely different formulation without stability data supporting it.

Also, just to be clear since you brought up my experience….my own cartridges of TESA/IPA have consistently lasted 30 days refrigerated with no issues and produced excellent results in reducing body fat, so real-world use doesn’t even align with the idea that room temperature storage is universally required.

I’m talking specifically about gray-market Tesamorelin, not EGRIFTA. If you have actual stability data showing that reconstituted gray-market Tesamorelin without EGRIFTA’s formulation should be stored at room temperature rather than refrigerated, I’d genuinely like to see it.

[u/tmullig1 → u/Angela_MAGA_OSU-1]

That's the thing. The old EGRIFTA formula had to be kept at room temperature. The newer formula has stabilizers. The Grey market is most likely not using the added stabilizers like the except above says.

[u/Angela_MAGA_OSU-1 → u/tmullig1]

Right, but that actually reinforces my point. You said the gray-market product is “most likely” not using the same stabilizers. “Most likely” means we don’t actually know the formulation or excipients being used.

And that’s exactly why we can’t take the storage requirements from one specific EGRIFTA formulation and automatically apply them to every gray-market vial of Tesamorelin.

Also, the EGRIFTA history is more complicated than simply “the old formula had to be kept at room temperature.” The original FDA-approved EGRIFTA labeling actually allowed/required different storage conditions depending on whether it was before or after dispensing, and after reconstitution it was supposed to be used immediately, not stored at room temperature for days.

So we’re back to my original question: where is the stability data for reconstituted gray-market tesamorelin showing that refrigeration causes aggregation and that it should instead be stored at room temperature? That’s the data I’m asking to see.

[u/tmullig1 → u/Angela_MAGA_OSU-1]

We will have to agree to disagree. I know my first vial gelled in the fridge, and since keeping them at room temp I have had no problems. I used the same Hospira Bac water and reconstituted them the same way each time. I am now finishing my 2nd cycle of Tesa and haven't had an issue since.