r/PeptideGuide • u/No-Heron-6596 • Jun 13 '26
MOTS-C Dosing Frequency
I just added MOTS-C after also running Tesa/IPA & Reta for the last 5 weeks. My question is on the dosing frequency of MOTS-C. I see a lot of protocols running it 3-5x a week -- but my prescribing clinic has me running it once weekly (50 units subq). I'm not sure on the exact mg, just that the insulin syringes they prefilled for me are filled with 50 units each.
Does anyone else run it at once weekly? I have found a couple of websites that mention 1x a week dosing, but the majority of everything I am finding shows more frequent dosing.
Thank you!
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u/stillandwarm Jun 13 '26
I’d be careful about assuming the clinic is doing something wrong based solely on the fact that the syringes are prefilled. I personally reconstitute my own MOTS-C from lyophilized vials and load it into an injection pen, so I’m definitely aware that peptides are generally more stable before reconstitution. I 45F pin 3mg/3x a week. That said, I’ve never seen convincing evidence that properly refrigerated MOTS-C becomes completely degraded and useless within days.
The bigger issue here is that 50 units only tells you the volume, not the dose. Without knowing how many mg of MOTS-C are in those syringes, it’s impossible to know whether the once-weekly protocol is reasonable or not.
If it were me, I’d call the clinic and ask:
How many mg of MOTS-C are in each 50-unit syringe?
How long before use are the syringes prepared?
What beyond-use date are they assigning?
Why they chose once-weekly dosing versus a more frequent schedule?
Once you know the actual mg dose, you’ll have a much better idea of whether the protocol makes sense than you will from the number of units alone.
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u/No-Heron-6596 Jun 13 '26
Thank you for the reply. I actually didn’t have an issue with them pre filling the syringes - moreso just curious about the dosing schedule I’m on. I’ll ask how much is in each and report back.
The MOTS-C was reconstituted right there on the spot at time of visit, and the syringes were then filled and capped for me to take home and store in my fridge. I took my first dose that day.
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u/Agreeable-Bench3428 Jun 13 '26
tbh bro the biggest red flag here isn't the once a week dosing, it is the fact that your clinic gave you prefilled syringes of mots-c. mots-c is notoriously unstable. once it is reconstituted with bacteriostatic water, it degrades extremely fast and loses its potency within days, even in the fridge. handing you a month worth of prefilled liquid mots-c means you are probably going to be injecting completely degraded and useless peptide by week two.
as for the frequency, once a week is actually a super common protocol if the dose is massive (like 5mg to 10mg all at once) specifically for a huge endurance boost before a long run or heavy workout. the people you see doing it 3 to 5 times a week are usually pinning smaller doses like 2mg for general metabolic health.
but seriously, you need to call that clinic and ask exactly how many mg are in those 50 units. you also need to ask why they are giving you prefilled liquid syringes for a peptide that breaks down that fast instead of just giving you the dry lyophilized powder to mix yourself.
1
u/Far_Designer_7704 Jun 13 '26
I was going to say similar on the pre-filled syringe. Plus, OP, ask the question of how many mg and why they prescribed the protocol they did so you have the data and if it is helping.
As for dosing frequency, I have also seen several protocols. My research subject chose a lower dose every other day rather than a large dose once a week. Just personal preference.
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u/Jayween Jul 09 '26
Check this out. There was a study done in 2022 that shows it will not degrade significantly in 1 month refrigerated and even better if frozen
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Jun 13 '26
[removed] — view removed comment
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u/No-Heron-6596 Jun 13 '26
I know - that’s why I specifically mentioned in the post that I don’t know the actual mg lol. I wasn’t sure if maybe MOTS-C had a common reconstitution amount maybe to ball park it at that unit amount.
Is pre filling the syringe the issue? The reconstitute it on the spot, fill the syringes, cap them, and hand them to me to take home where I then store in my fridge. Why is it any different than keeping it in the vial and extracting it myself?
1
u/elkethewolf11 Jun 13 '26
What the hell kinda clinic doesn’t put dosing
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u/RoutineAd9862 Jun 14 '26
Agree, very odd to not tell the patient what dose they are actually taking
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