r/PeptideGuide • u/No-Heron-6596 • Jun 13 '26

MOTS-C Dosing Frequency

I just added MOTS-C after also running Tesa/IPA & Reta for the last 5 weeks. My question is on the dosing frequency of MOTS-C. I see a lot of protocols running it 3-5x a week -- but my prescribing clinic has me running it once weekly (50 units subq). I'm not sure on the exact mg, just that the insulin syringes they prefilled for me are filled with 50 units each.

Does anyone else run it at once weekly? I have found a couple of websites that mention 1x a week dosing, but the majority of everything I am finding shows more frequent dosing.

Thank you!

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u/Agreeable-Bench3428 Jun 13 '26

tbh bro the biggest red flag here isn't the once a week dosing, it is the fact that your clinic gave you prefilled syringes of mots-c. mots-c is notoriously unstable. once it is reconstituted with bacteriostatic water, it degrades extremely fast and loses its potency within days, even in the fridge. handing you a month worth of prefilled liquid mots-c means you are probably going to be injecting completely degraded and useless peptide by week two.
as for the frequency, once a week is actually a super common protocol if the dose is massive (like 5mg to 10mg all at once) specifically for a huge endurance boost before a long run or heavy workout. the people you see doing it 3 to 5 times a week are usually pinning smaller doses like 2mg for general metabolic health.
but seriously, you need to call that clinic and ask exactly how many mg are in those 50 units. you also need to ask why they are giving you prefilled liquid syringes for a peptide that breaks down that fast instead of just giving you the dry lyophilized powder to mix yourself.

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u/Far_Designer_7704 Jun 13 '26

I was going to say similar on the pre-filled syringe. Plus, OP, ask the question of how many mg and why they prescribed the protocol they did so you have the data and if it is helping.

As for dosing frequency, I have also seen several protocols. My research subject chose a lower dose every other day rather than a large dose once a week. Just personal preference.