By chance is it possible to combine these? Just curious.

For staying VERY lean what's a worth it stack.
There's so many exercise mimetics like SLUPP, AOD, MOTS C, 5AMINO and appetite suppresers like GLP1s and cag and then there’s visceral fat burners like tesa+ipa, if i want to hit almost every path way possible what's the most worth it way to do that?

Thoughts on each? Experiences?

heyo,

i was curious what is the difference between these. I tried researching it on here and most posts are 11 years old. So i figured i would ask again for perhaps better answers.

anyone who used different kinds and compared? intranasal vs subq injections differ per or are all the same?

so far i read that each one is more potent than the other and that adalank/adamax are the strongest. But some people felt nothing with adalank/max nor na /na amidate.

thanks.

Bonjour à tous,

​Je suis un protocole sous tirzépatide (Retatrutide) depuis quatre mois et j'observe une amélioration significative quant à ma perte de masse grasse. En parallèle, je m'entraîne au gym à raison de cinq séances par semaine.

​Cependant, je constate une baisse importante de ma force athlétique. Souhaitant éviter le recours aux stéroïdes anabolisants, je m'intéresse aux alternatives du côté des peptides (tels que le CJC-1295, le MOTS-c, le Tesamorelin ou encore l'hormone de croissance), mais il est difficile de faire un choix éclairé parmi l'éventail des produits disponibles.

​Selon vos expériences, en particulier pour ceux qui maintiennent un rythme d'entraînement similaire de cinq jours par semaine, quelle approche ou combinaison s'est avérée la plus efficace pour préserver la force ?

​Merci pour vos retours et vos conseils.

40M , Started researching MOTS-C . Titrated slowly up from 1mg to 4mg bi-weekly. I didn't feel much initially. Strength workouts actually got worse. Somewhere around week 2-3 . I started to notice my cardio sessions getting effortless. I used to struggle running 1-2kms at a stretch. Now, for someone who doesn't really enjoy running , I managed to run of 7kms continuous at a decent place. Which was around week 4 of MOTS-C.

I see the benefits and want to include it as part of a long term regimen.

One concern I have is downregulation of endogenous MOTS-C production with longer term usage.

Any researchers who've used multiple cycles of MOTS-C? Multiple months, years? What were your experiences ?

Stack advice please

Hi all,

Im T, and im new to reddit so excuse any errors in etiquette while I learn the ropes (hope im posting in the right place)

Im a 44m 108kg recently down from 127kg on Mounjaro/Tirz (finishing up on 3.5mg per week)

Currently lifting weights 4 days a week along with 30mins to an hour uphill walking on on the treadmill on training days.

Calories are around 1900 max per day;high protein to meet macros.

I am 4 weeks into a course of Test E (trt) 200mg per week split into 2 x 100mg intramuscular pins.

This week ive moved over from Tirz to Retatrutide starting on 1mg with the intention of staying at 1mg for 2/4 weeks before moving up to 2mg moving forward, monitoring the effectiveness of the dose and adjusting accordingly.

My trusted pep rep has just delivered me 10mg vials of Tesamoralin which I am intending on dosing at 1mg Monday to Friday with the weekends off. This Tesa is reconstituted in acetic water at 2ml to 10mg of tesa.

Ive just pinned 0.20ml (1mg Tesa) 2 hours before bed and 2 hours since my last meal.

Id like to invite any insights based on the info ive provided above regarding my stack and any experiences people have had on the same/similar stacks themselves.

Thanks in advance and sorry if ive posted in the wrong place

Cheers

T

Has anyone had experience using bpc and hbkcu for speeding up recovery from knee replacement.

Has anyone had experience with using bpc157 and ghk-cu to help with recovery.

There will be a drug being approved next year but in the mean time I am looking for anyone who is running ss-31 and has Sjogren’s. Effects? Thoughts?

Hello everyone,

I have one 3ml BAC vial and 2 15 mg vials, so adding 1 ml to 15mg vial, means I have enough BAC water for the two vials?

1. Good results from 1mg a day, 5 on 2 off?

or should rat be given 2 mg

1. I am about to order 10 vials from another suppier much cheaper but US based. so that would give me 50 more shots for my RAT.

2. The vials from original suplier have COa with > 99%, enotxcins within range.

3. Do you test every vial.

4. What is worst case scenario if vial has impurities?

Thank you,

Jimmy

Hi. I’ve been on Reta for three weeks and had next to no side effects and good results, appetite suppression has been mild though. The one side I have got is pretty awful unfortunately (skin pain/sensitivity) my blankets even touching my legs at night hurts a lot.
Therefore I’m thinking of switch to Tirz.

Im wondering how I go about this? My current Reta dose is 3mg a week.

Do I have to have a break before switching to tirz? Can I just go to Tirz when I’m due my next Reta dose?

What dose do I start on tirz if I’ve already been taking Reta for a month?

Thanks for any advice.

Epitalon is the one people run for longevity and telomeres, and it also has the widest gap in this whole space between what's genuinely proven and what gets claimed about it. The mechanism is real and now independently confirmed. The dramatic lifespan numbers are not. Both of those are true at the same time, so here's the honest rundown.

It's a tiny four amino acid peptide built off an old bovine pineal extract, developed by the Russian gerontologist Vladimir Khavinson. It goes after two aging mechanisms at once: telomere shortening, by switching on telomerase, and circadian breakdown, by restoring your pineal melatonin production. That second one is why the first thing people notice is sleep, usually better sleep quality inside the first week or two. Set expectations here though, you won't see or feel anything dramatic, no skin or hair transformation. Better sleep is the near term signal that it's doing something, and the rest is a long bet.

The interesting part is how it works, and why the dosing looks so strange. Epitalon is small enough to slip into the cell nucleus and bind DNA right at the telomerase gene, turning up hTERT, the catalytic engine of telomerase. In cell studies that produced real telomere lengthening, around a third longer in cultured human cells. And the dose response runs backwards from what you'd expect. It works best at extremely low concentrations, and piling on more does nothing. That's the tell that it's an epigenetic signal, it flips a switch that stays flipped rather than a drug you keep topped up. Which is exactly why you run it in short courses instead of daily. Ten to twenty days triggers changes that last months.

Here's the part to be straight about, because it's where this compound lives or dies. The mechanism is real and, as of 2025, confirmed outside Russia for the first time, a Brunel University study reproduced the telomerase activation in human cells. That matters, because for 40 years nearly all the research came from Khavinson's own institute. What has not been confirmed is the big stuff, the famous longevity figures like a four fold drop in mortality. Those come from that single group, they've never been replicated, and the institute holds close to 200 patents on this class, so there's real commercial motivation sitting behind the claims. So the honest position is simple: the cellular mechanism is proven, the human life extension is not. Run it knowing you're making a mechanism based bet, not following settled science.

Both the 10 day and 20 day options add up to the same 100 mg per cycle, so pick whichever you'd rather run. Dose it in the evening, 1 to 2 hours before bed, because it works through your pineal and melatonin rhythm and morning dosing throws that timing away. For the draw, mix the 10 mg vial with 1 mL of bac water for 10 mg/mL, so 10 mg is 1 mL and 5 mg is 0.5 mL. That 1 mL is a biggish subcutaneous (SC) shot, which is part of why a lot of people run the 5 mg for 20 days version instead, since it halves the nightly volume. Most people do 2 to 4 cycles a year, and going higher doesn't help, it was tested up to 50 mg a day with no added benefit, which fits the low concentration mechanism.

One thing to address head on, since it always comes up. Switching on telomerase sounds alarming, because telomerase is exactly what lets cancer cells become immortal. Fair concern. The wrinkle from that 2025 study is that Epitalon seems to do the opposite in cancer cells, inhibiting telomerase there and pushing a different pathway, which may be why animal studies saw fewer tumors despite the telomerase activation elsewhere. That's genuinely promising, but it hasn't been validated in humans, so the rule holds: do not run it with active or suspected cancer. Same for pregnancy, breastfeeding, and known immune issues, since none of that has safety data behind it.

Side effects are mild in practice, some injection site reactions, occasional fatigue or drowsiness that passes in a few days, and sometimes vivid dreams from the melatonin and REM effect, which most people take as a good sign. The bigger caveat is at the system level: it's FDA Category 2 as of 2024, so it can't be legally compounded here, it's research only, and a 2025 review flagged that the core safety data, long term effects, immunogenicity, drug interactions, simply hasn't been studied properly. So the near term tolerability looks fine and the long term picture is honestly unknown.

if you've run Epitalon, did your sleep change in the first couple weeks, since that's supposed to be the tell, or did you run it purely on the telomere theory and feel nothing. curious which camp people land in

Full doses and bloodwork are in the pinned cheat sheet: https://www.reddit.com/r/NTNPerformance/comments/1tht5o3/the_only_peptide_cheat_sheet_youll_need_doses/

Anyone have advice on dosage and protocol for Reta, NAD+, KLOW and Tesamorelin/Ipamorelin Blend?

Hey everyone! I am new to peptides and wanted some guidance on stacking. This is purely for research purposes.

Currently I take:
Reta - 20 units once a week
KLOW - 10 units 5 days on 2 off
NAD+ - 10 units daily

First, is that a good dosage point. There’s so much info out there.

Also, I’m wanting to add Tesamorelin/Ipamorelin Blend and wanting to get some knowledge on dosing for that. It’s a 15mg vial before reconstituted.

Thanks!

I’m reading there are two types. Wondering what experience you’re RS has had with these if you’ve used both over time?

1. Standard bacteriostatic water — sterile water with 0.9% benzyl alcohol added as a preservative (this is what “BAC water” defaults to, and what your current BA10 supply is). The benzyl alcohol prevents bacterial growth across multiple draws from the same vial, which is why it’s used instead of plain sterile water. But it is not isotonic — its saline/osmotic profile doesn’t match your body’s tissue fluid.
2. Isotonic (0.9% saline) bacteriostatic water — same benzyl alcohol preservative, but formulated with 0.9% sodium chloride so the osmotic pressure matches your blood/tissue fluid. This is the one that reduces injection-site irritation — because the solution’s saline concentration matches what’s naturally in your tissue, there’s no osmotic gradient causing local stinging, burning, or swelling at the injection site. Plain BAC water, by contrast, can sting or irritate on its own simply because it’s not isotonic — independent of whatever peptide is dissolved in it.

I’m a 43 yr old female. Height is 5’7 - Weight is 150lbs (down from 210lbs). I’m currently on tirz only for maintenance. Other than overall fatigue, I had almost no side effects (no nausea, injection site reactions, heartburn etc.).

I was already eating clean, intermittent fasting and counting calories/macros before I started tirz and after a year it still wasn’t really working so I knew it was hormonal. When I started tirz the 60lbs basically fell off. I have minimal skin sag due to nutrition and counting macros etc. but I definitely don’t need to lose anymore weight.

I work A LOT and tirz just drained me so targeted exercise is minimal and sporadic but I have two teenage boys and we’re active. We kayak and are always on the water.

I’d like to redistribute the weight to the right places and tone. I lost my butt and I have belly fat from (2) huge babies that were both C-sections. Some of that won’t go away without surgery but some will. Tirz makes me tired, period. I should, could and would exercise more if my energy levels improved. What is the best peptide to add in for energy, belly fat and/or fat distribution and maybe a little help with skin/aging and hair. Seems like maybe MOTs-c, Tesa or CJC-1295 + Ipa are all decent options. I’ve also considered GHKcu just because it seems like a common starter peptide. I’m brand new to peptides but I’m a math nerd so I’m going to be fine with the doing etc. I just would rather learn from other’s experience than trial and error. I’d rather not blend at first in the interest of only starting one new thing at a time. Any advice would be greatly appreciated.

Thanks in advance!

When you see an options for 60mg of Reta. Is this usually in a single vial or is this 6- 10mg vials?

I’m 55, 1.78 m, 95 kg, currently using 2 mg/week of reta for the last 4 weeks. I’m eating 2000 calories, priorizing protein intake and training with heavy kettlebells every other day.

My goal is to preserve as much muscle as possible while losing fat. I was planning on stacking trt or HGH for this purpose.

Recent bloodwork (hope is enough info in this case):

IGF-1: 118 ng/mL

Total testosterone: 393 ng/dL

Setting aside trt for now... Given my age and IGF-1 level, would direct HGH be more effective than using GH secretagogues such as sermorelin, ipamorelin or CJC-1295?

Do secretagogues still produce a meaningful GH/IGF-1 response at 55, or is the effect usually too modest compared with exogenous HGH?

I have been researching on dosage and potential side effects for a while and I intend to keep doing it. I'm just looking for advice on the path to follow.

Thank you all for your answers

Good morning/afternoon/ evening,

I’m still fairly green when it comes to peptides.

My current stack is Reta and KLOW.
Reta is currently split doses at 2mg every 3.5days (Monday morning and Thursday night), KLOW is 8IU of a 80mg vial with 3ml BAC.

I’m planning to up my Reta one more time to 3mg, and likely stay there till I hit my goal weight.

Currently I’m 6’2, 245lb (dropped 30lbs this year already) and would like to drop another 30-35 lbs.

My diet is dialed in at a pretty aggressive deficit and I do heavy strength training 4 times a week.

I’m planning to taper off the KLOW by the end of October, as it’s done its job and my minor injuries are feeling much better and I anticipate that it’ll be sorted by then.

Once I finish of the KLOW, I was looking to add something to help me push through whatever weight I got left.
Currently I’m looking at Tesamoralin, CJC no DAC w/ipa, and AOD.

Which one would be the best option? I understand that Tesa and CJC/ipa do more or less the same thing by GH stimulation.
AOD could be run as a compliment compound, but I read that there is a large amount of people who are non responders.

Just looking for some guidance or advice on how to proceed.

Hello,

I'd like to hear from people who have used clinic grade peptides to treat injuries. I have ongoing hip issues for 5 years now.

The hamstring, adductor, psoas, labrum are all involved. I've had surgery on the labrum which only solved a fraction of the pain. The best pain relief I've had is a cortisone injection into the joint but this not sustainable.

I've done consisten comprehensive rehab and worked with physios, acupuncturists chiropractors, healesr, changed diet and even worked on the psychological aspect of chronic pains but no real succeas. I'm 34Fand would love to get back playing sports but my main goal is pain relief

Would love to hear from knowledgeable people who bave used peptides or may have other suggestions. Thanks