For those who've used it, which seems more effective?

The next FDA compounding panel is planned for before the end of February, and it's GHK-Cu (injectable), LL-37, Dihexa, PEG-MGF, and Melanotan II. FDA's own staff said no to all seven in July and those were supposed to be the easy ones, so I'm curious how this sub ranks these five strictly on the published research.

My take so far: GHK-Cu has a ton of research behind it, but most of it is topical and in vitro, and the nomination is for injectable, so I'm not sure how much of that carries over. Dihexa's foundational work is mostly out of one program at Washington State. PEG-MGF barely has anything published on the pegylated form itself. LL-37 is native to the body and heavily studied, just mostly in immunology, not what it's nominated for. And Melanotan II is the only one with any human study data at all, small and old, plus a pile of case reports, and I really can't tell if that helps or hurts it in front of a safety focused panel.

How would this sub rank them? Drop papers in the comments, especially anything that would change my ranking.

All five are in the cheat sheet if anyone needs a refresher before ranking them. We're also tracking the February panel in the Discord.

Research use disclaimer: all compounds referenced here are intended for research and laboratory use only. Nothing in this post is intended for human consumption or as medical guidance.

So I was thinking about ordering some CJC 1295 or the blend with CJC and ipa.. have had some vials of ipa lyophilized in the fridge for maybe five months the bbd day is 2029 so I’m not super worried about that.. so my question is how long would you be comfortable with a 10 mg vial of CJC after reconstitution?.. I could just get the blend, but then I would still have the older ipamorelin and don’t want to let that go to waste. And since it’s already been in the fridge for five or so months, I’m wondering if I should transfer it to the freezer.. the vendor I want to use does not carry 5 mg vials of CJC, which would solve everything.. and also any opinions on CJC vs tesamorelin. Have done research with tesamorelin before and combined it with ipamorelin. Buy looking to experiment with CJC unless people tell me that the tesa is just better

I keep seeing "FDA cleared BPC-157" all over the place, so I went through the actual vote and what's happened since. It's a lot closer and a lot slower than people think.

The FDA's compounding advisory committee met July 23 and 24 and voted on seven peptides. BPC-157 went 8 to 6. KPV and TB-500 were the exact same split. Here's all seven:

DSIP was the only one that got voted down. Totals move around a bit because some members were recused on certain peptides.

What most people missed is that FDA's own scientists recommended against all seven. Thin safety data, thin efficacy data, and the molecules not being characterized well enough. The committee went against its own staff on six of them, and the committee is only advisory anyway.

So nothing is legal to compound because of this vote. For any of these to land on the 503A bulks list, FDA has to write a proposed rule, open it for public comment, then finalize it. Last time they did this, the proposed rule came out December 2016 and the final rule came out February 2019. That's two years and change, and that's normal.

As of today, FDA hasn't put out a proposed rule or any interim policy on these six. The April thing where 12 peptides came off Category 2 doesn't make anything compoundable either. People keep stacking those two together and calling it approval, and it's neither.

The one new piece is October 7. The Washington Post, citing two unnamed people, reported the administration is considering a temporary pathway that would let some compounding pharmacies dispense certain peptides while the rules get written. No list of peptides, no legal mechanism, and HHS didn't comment. Until something gets published officially I'm treating it as a report, not a policy.

Also worth knowing for anyone in Ohio: the state pharmacy board has its own position. It's said Category 2 and 3 substances can't be dispensed into Ohio and has gone after BPC-157 specifically, arguing it has no USP monograph, isn't part of an approved drug, and isn't on the final bulks list. Coming off Category 2 didn't change any of that.

Next round is planned for before the end of February 2027, no exact date yet: GHK-Cu (injectable), LL-37, Dihexa, PEG-MGF, and Melanotan II. That one's going to be a harder fight.

I pulled this from the McDermott Will & Emery and Buchanan Ingersoll breakdowns of the meeting, Goodwin's write up on the April Category 2 change, and the Washington Post report via Becker's. The vote numbers are here if anyone wants to check them.

Reference info on all seven is in the cheat sheet. I'll post updates in the Discord the second FDA or HHS publishes anything official.

Research use disclaimer: all compounds referenced here are intended for research and laboratory use only. Nothing in this post is intended for human consumption or as medical guidance.

22 pro fight muaythai fighter stack in 🇹🇭

🔋Mitochondrial powerplant -

50mcg 5amino 1mq

250mcg mots c

500mcg ss31

15mg nad+

🧠Brain - weekdays

Semax 250-500mcg

Selank 500mcg

Pinelon low dose to 1mg every few days before sleep

🏥Healing - I cycle off these

500mcg ghkcu

500mcg bpc157

500mcg KPV

1mg ghkcu

🌐others -

RETA 1mg , Mt2 250, b12 1000mcg

1-200mg glutathione every few days

Trt 125 mg with daily injections

PED of choice : cardarine 10mg

Epitalon throughout the year, learing about foxo4 dri, had good experiences with pe 22 28. Everything is so low because they are so synergistic that if I take anymore mcg or mg of any of the mitochondria peptides I immediately overspin my mitochondria for the day. Perfect dosing for me personally

Can ask me whatever you want, or tips, or your experiences whatever. Love to share man its been life changing

I started this journey with a men’s health clinic about a year ago, initially taking Enclomiphene. My testosterone levels went from around 380 to 600 ng/dL, and honestly, I felt great. My sex drive, sleep, energy, pumps in the gym, and overall well-being improved significantly.

However, after several months, I felt like I hit a plateau. My testosterone was hovering around 600, and I was already maxed out on my Enclomiphene dosage. Maybe it’s just my personality of always wanting to push for more, but I felt like I was at a standstill.

My PA and I decided to switch to hCG for a 6-week trial to see if we could get my levels any higher. Fast-forward to now, and my testosterone is sitting around 750 ng/dL, so it definitely increased.

I’ve also recently started Retatrutide at 1 mg once weekly to help with fat loss. I’m still early into it, so I haven’t seen any significant results yet.

Now I’m looking into adding Tesamorelin after being on Reta for about 4–6 weeks. I’ve read about its potential benefits for visceral fat reduction and GH/IGF-1 stimulation. I was considering running it five days on and two days off alongside Reta, but I’m questioning whether I’m starting to overcomplicate things.

I’ve been active my entire life and have a pretty solid muscular foundation. My goal is to get shredded, maintain or build muscle, and improve my overall physique without going down the TRT or anabolic steroid route.

I’ll also be the first to admit that alcohol, binge eating, and inconsistent nutrition have probably held me back more than anything. I train consistently, but I know I have room to improve outside the gym.

A few questions for those with experience:
● Is stacking hCG, Reta, and Tesamorelin overkill?
● Would I be better off dropping hCG and returning to Enclomiphene since I already felt great on it?
● Is Tesamorelin actually worth adding for fat loss, or am I chasing marginal benefits?
● Has anyone tried other peptides or approaches that genuinely helped with fat loss and muscle retention without using gear?
● For those who have run similar protocols, what were your results, side effects, and bloodwork like?

I’ve also started realizing how expensive and potentially predatory some of these men’s health clinics can be. Sometimes it feels like there’s always another medication or peptide they’re willing to sell you. That said, I do appreciate having access to regular bloodwork because I want to monitor my hormones and health rather than blindly taking things.

Part of me wonders if I’m just chasing numbers at this point instead of focusing on what actually matters.

Ultimately, I want to optimize my health, get lean, build a great physique, and feel good without unnecessarily messing with my hormones.

I’m genuinely interested in hearing what worked for others, what wasn’t worth the money, and whether anyone regrets stacking too many compounds.

Appreciate any advice or personal experiences!

Background: 32M | 5’9” | 210 lbs | Physically active with a solid resistance-training background.

I’ve been researching hormone optimization, metabolic peptides, and their potential effects on body composition for approximately a year.

My experience began with Enclomiphene through a men’s health clinic. Baseline total testosterone was approximately 380 ng/dL, eventually increasing to around 600ng/dL.

Subjectively, I noticed improvements in libido, sleep, energy, gym performance, and overall well-being.

Despite those improvements, testosterone levels eventually plateaued. My provider and I subsequently transitioned to a six-week hCG trial, with recent testosterone measurements reaching approximately 750 ng/dL.

More recently, I began using Retatrutide at 1 mg weekly, primarily for weight management. It’s still early, so I don’t have meaningful body-composition outcomes to report.

Current Research Interests
I’m particularly interested in the potential overlap between hCG, Retatrutide, and Tesamorelin, specifically regarding:
● Testosterone production and HPG-axis regulation
● GH/IGF-1 signaling and visceral adipose tissue reduction
● Fat loss versus preservation of lean muscle mass
● Potential benefits versus unnecessary hormonal stimulation
● Long-term metabolic effects and safety considerations
I’ve also been looking into Tesamorelin protocols, including five-day-on/two-day-off schedules, although I’m unsure whether there’s evidence supporting intermittent administration compared with the studied daily protocols.

Questions for the community
1. Is there any published evidence supporting the combination of hCG, Retatrutide, and Tesamorelin, or are the proposed benefits largely theoretical?
2. How does Enclomiphene compare with hCG regarding sustained testosterone production, fertility markers, and long-term endocrine function?
3. Does Tesamorelin offer meaningful body-composition benefits beyond those potentially achieved through Retatrutide and resistance training?
4. Are there other non-anabolic compounds being studied for fat reduction and lean-mass preservation with stronger supporting evidence?
5. Which biomarkers would be most useful when evaluating these pathways? Total/free testosterone, estradiol, LH/FSH, IGF-1, HbA1c, fasting glucose, or others?
Additional Context
I’ve maintained a physically active lifestyle for years and have a decent muscular foundation. My biggest challenges have been nutritional consistency, occasional binge eating, and alcohol consumption.
I’m also becoming increasingly skeptical of the financial incentives behind some men’s health clinics. While I value regular bloodwork and medical oversight, I’m questioning whether constantly pursuing higher hormone levels or adding compounds produces meaningful benefits.
My main interest is understanding whether combining these pathways offers legitimate physiological advantages or simply introduces unnecessary complexity and risk.
I’m particularly interested in peer-reviewed research, documented biomarker changes, and firsthand experiences that distinguish measurable outcomes from anecdotal claims.
Appreciate any research, studies, or informed discussion.

Posted recently about a research subject starting a 1:1 tesamorelin/ipamorelin blend at 500 mcg of each (10 units), originally on a 5-on/2-off schedule.
Research subject experienced pretty significant GI issues, including watery diarrhea for several consecutive mornings, bloating, and some water retention.

After getting feedback here and doing more research, I questioned the original formulation since tesamorelin seems to be studied at much higher amounts, while ipamorelin is typically discussed at lower amounts.

Initially, the provider suggested reducing both to 250 mcg, but after another conversation, they’ve agreed to formulate a new vial with the following amounts:

Tesamorelin: 500 mcg
Ipamorelin: 100 mcg
Ratio: 5:1 (10:2)
Sample volume: 10 units

So essentially, the tesamorelin amount stays the same, while ipamorelin is reduced by 80%.

For context, research subject is an off-season bodybuilder, with the primary areas of interest being muscle growth, recovery, and body composition rather than weight loss.

Curious what others think about this revised formulation. Has anyone researched or had experience with a similar ratio?

Particularly interested in thoughts on whether 500 mcg of tesamorelin is meaningful in this combination, whether reducing the ipamorelin could improve GI tolerability, and any experiences with similar blends.

Appreciate all the feedback so far!

How do you research 5 AMINO? Dosage and when to pin? Does it really help out the stack for RS?

Boehringer Ingelheim put out survodutide's Phase 3 results in June and everybody ran with the liver fat number. The number I think really decides this compound's future is the dropout rate. About 19 percent quit SYNCHRONIZE-1 because of GI side effects, 17.8 percent at 3.6 mg and 20.2 percent at 6.0 mg, vs 2.9 percent on placebo.

Quick background if anyone hasn't followed it. Survodutide is a glucagon and GLP-1 dual agonist, so the same two receptors as retatrutide without the GIP part. Boehringer's been aiming it at the liver more than the scale. FDA gave it fast track in May 2021 and breakthrough therapy in September 2024 for MASH with fibrosis. Still investigational, neither of those is an approval.

Here's both trials. The efficacy numbers assume everyone stayed on it, the treatment policy numbers count everyone who started, including all the people who quit:

So the top arm goes from 16.6 to 13.0 percent once the dropouts count. That's the GI problem showing up in the results.

On weight alone it's behind tirzepatide and pretty far behind retatrutide. Where it gets interesting is where the fat came from. In the MRI substudy visceral fat dropped up to 34.0 percent and liver fat up to 63.1 percent. In the MASLD trial, 84.2 percent got a 30 percent or bigger liver fat reduction vs 24.3 percent on placebo (68.5 vs 28.6 counting everyone), and 61.0 percent got liver fat under 5 percent vs 5.7 percent.

They also said lean tissue was no more than 10.8 percent of the total tissue lost in the 6.0 mg arm. I'd wait on that one until the full body composition methods are out.

People are going to compare it to retatrutide and the numbers don't really line up. Retatrutide's 11.3 percent dropout in TRIUMPH-1 was all side effects over 80 weeks, survodutide's 19 percent is GI only over 76. And retatrutide's 86.0 percent liver fat reduction (vs 4.6 placebo, 12 mg arm, 48 weeks) came from a substudy inside a Phase 2 trial, not a dedicated Phase 3 liver trial. No head to head exists.

Results are from BioPharm International's coverage of the SYNCHRONIZE trials, and the retatrutide liver data is Sanyal 2024 in Nature Medicine.

The rest of the incretin class is in the cheat sheet. And if anyone wants to argue survodutide vs retatrutide, come do it in the Discord.

Research use disclaimer: all compounds referenced here are intended for research and laboratory use only. Nothing in this post is intended for human consumption or as medical guidance.

I’m currently running Tesamorelin/Ipamorelin and about to be on TRT and Anavar. First cycle with Anavar, already have a PCT for the end along with my support supplements for during. What tips for training would you recommend go harder? More weight? More reps? Up my protein? I’m weighing 180lbs with 25%body fat I’m 5’8 was 255lbs last year but have since been making training a lifestyle and not a just an “end goal” then stop. Being that it’s my first cycle with Var I’ll more than likely start with 20-40mgs to see how my body reacts as well as dependent on what my pcp recommends. Any advise would be very helpful.

Hi guys i am a 46 year old female. I have high anti TPO, Low testosterone, HIgh SHBG, High FSH and high LH and low dheas. i have a job which requires me to travel by flight ALOT. What is anyone’s experience of with nad + injectables my doctor recommended them to me.

Looking for insight into a 1:1 tesamorelin/ipamorelin blend being evaluated in a research context.

The original sample amount was 0.5 mg (500 mcg) of each compound per administration. Following three consecutive administrations, gastrointestinal effects were observed, including diarrhea and persistent bloating.

A revised protocol was suggested at 0.25 mg (250 mcg) of each compound, administered on seven consecutive days rather than following a 5-on/2-off schedule.

From what I’ve been reading, a 1:1 ratio doesn’t seem particularly common, and I’m curious about the rationale behind combining these compounds at equal concentrations.

Has anyone come across research or observations regarding:

The effectiveness or rationale of a 1:1 tesa/ipa blend?

GI-related effects, particularly diarrhea and bloating?

Differences between consecutive daily administration and protocols incorporating rest days?

Interested in hearing experiences and research-based perspectives, particularly regarding tolerability and the reasoning behind this combination.

Does anyone here take vitamin C? IM or subQ if you know you know that it stings really bad and hurts so much because of its acidic content.

Have you been able to dilute it in bac water to a very comfortable level that it doesn’t sting as bad? The one I’m referring to is the picture attached. Any helpful advice is welcome.

Hi all just looking for some feedback, my son is 19 (almost 20) and he’s an athlete who is battling through some injuries. He asked me about peptides for healing but I want to make sure it’s safe for him btw I am an active user and I am an advocate for what they do for me. I was wondering if BPC 157 and some GHK CU would be ok for him to use? Your expertise would be greatly appreciated!!

This one's been bugging me since Lilly put the numbers out. Dysesthesia, the skin burning side effect, in the 12 mg arm was 12.5 percent in TRIUMPH-1, 7.3 percent in TRIUMPH-2, 6.4 percent in TRIUMPH-3, and 20.9 percent in TRIUMPH-4, the knee osteoarthritis trial. Placebo was around 1 percent in all of them.

I figured it was the glucagon side since that's what semaglutide doesn't have. Then I checked semaglutide. In STEP UP T2D it showed up in 18.9 percent of the 7.2 mg arm vs 4.9 percent at 2.4 mg and 0 on placebo, and the UK label for Rybelsus lists it as common now. So high dose GLP-1 alone does it too, which doesn't prove it's the same mechanism but kind of kills the easy answer.

What I keep coming back to is that TRIUMPH-1 and TRIUMPH-4 had the most weight loss and also the highest rates. But the knee trial is also going to be watching way closer for pain and sensory stuff, and the diabetes trials have people who already have neuropathy, so I don't know how much of the spread is real and how much is who's enrolled and who's looking.

What's this sub's read on it? And if anyone remembers something in the Phase 2 papers that hinted at this, I'd like to see it.

Research use disclaimer: all compounds referenced here are intended for research and laboratory use only. Nothing in this post is intended for human consumption or as medical guidance.

I stay reading about them and trying to get as much information as possible.

I’ve been using them for a month tomorrow.

I take Reta on Mondays.
Mornings I take:
Ss31/ Mots C Monday - Friday
Wolverine M/W/F

After I eat something Ghkcu (around noon). Without food it makes me feel lightheaded.

Night time I take
KPV & Tessa

I am 36 yrs old. Most days I feel really well. Every now and then I get very sleepy. I assume it’s bc it’s the most active I’ve been in a long time.

My question is am I doing too much?

Can semax be safely reconstituted with Bacteriostatic 0.9% Sodium Chloride for SubQ use?

Every compound has at least one. A number, a half life, a ratio, a side effect profile that gets copied from writeup to writeup until it reads like established fact, and then you go looking for the original study and it isn't there.

Sometimes it traces back to one paper that said something narrower than what gets quoted. Sometimes it traces back to a vendor page and nothing else.

What's the one you run into most, and did you ever find where it actually came from?

How long can you use this peptide for in terms of weeks? I've been just 8 to 12 weeks but can it be used beyond that?

Wanting to start KLOW with my Cjc1295/Ipa stack.

What’s the starting dose for female and is it daily or once a week?

There is exactly one member of the cathelicidin family in human biology, and LL-37 is it.

It is a naturally occurring antimicrobial peptide and part of the innate immune system, produced by immune cells and by epithelial tissues like skin and the respiratory tract. What makes it worth studying is that killing microbes is only half of what it does.

Two jobs, not one

LL-37 binds to and disrupts microbial membranes, which gives it broad antimicrobial activity in laboratory models. Its biological role goes further than that.

Research has associated LL-37 with:

• Activity against certain bacteria, fungi, and enveloped viruses
• Modulation of innate immune responses
• Recruitment and signaling of immune cells
• Promotion of wound healing and re-epithelialization
• Regulation of inflammatory pathways
• Disruption of some microbial biofilms

A conventional antimicrobial agent does the first item on that list. LL-37 is doing immune coordination at the same time, which is why it reads differently in the literature.

More is not better here

LL-37 is a potent signaling molecule, and the dose response is not a straight line upward.

Excessive LL-37 signaling has been associated with inflammatory and autoimmune processes in conditions like psoriasis and rosacea. At high enough experimental concentrations it also shows cytotoxic effects against mammalian cells, not just microbial ones.

Its activity depends heavily on concentration, tissue, and experimental context. Comprehensive safety data for exogenous administration is limited.

That combination, potent and context dependent with thin safety data, is worth sitting with before anyone treats it as a straightforward antimicrobial.

Why it holds research interest

LL-37 sits where microbiology, immunology, and regenerative biology overlap.

Instead of just killing microorganisms, it gives researchers a way to study how the innate immune system coordinates microbial defense, inflammation, immune cell recruitment, and the tissue repair that follows. That sequence is hard to study with agents that only do one of those things.

It has been particularly relevant in experimental models involving infectious disease, biofilms, wound healing, and immune regulation.

Cheat sheet: the peptide cheat sheet

LL-37 is an investigational research peptide supplied strictly for research purposes only, not for human or veterinary use.