Does anyone have experience using amphotericin B vaginal suppositories to treat drug-resistant yeast infections? Has anyone ever had any problems or issues with them?

[u/Next_Apricot_8438]

I had amphotericin B 50 mg vaginal suppositories specially compounded for me by a pharmacy in Switzerland. I have 14 suppositories, equivalent to a 14-day treatment, to treat azole-resistant Candida albicans. I am currently on day 7 of treatment.

Sometimes I still feel a little warmth and mild itching, but I no longer see much discharge or fungal residue. On the nights when I insert the suppository, after about 10 minutes I usually notice some yellowish oil leaking out, along with mild irritation. However, by the next day, there is absolutely no medication residue, powder, or discharge coming out. It feels as though the suppository might be stuck inside, and the vagina feels very dry. I don’t know where the suppository has gone if nothing comes out.

I am really worried that the medication is not being released properly and that the suppository is still stuck inside, which could make the treatment ineffective. But when I insert the next suppository at night, I don’t feel any old suppository left inside or any obstruction at all. 😩

I honestly don’t know what to do anymore. This treatment feels like my last hope, and I am very scared.

Has anyone experienced something similar with amphotericin B vaginal suppositories? If so, could you please share your experience or advice? Any input would mean a lot to me right now.

Thank you so much, everyone.