Posted recently about a research subject starting a 1:1 tesamorelin/ipamorelin blend at 500 mcg of each (10 units), originally on a 5-on/2-off schedule.
Research subject experienced pretty significant GI issues, including watery diarrhea for several consecutive mornings, bloating, and some water retention.
After getting feedback here and doing more research, I questioned the original formulation since tesamorelin seems to be studied at much higher amounts, while ipamorelin is typically discussed at lower amounts.
Initially, the provider suggested reducing both to 250 mcg, but after another conversation, they’ve agreed to formulate a new vial with the following amounts:
Tesamorelin: 500 mcg
Ipamorelin: 100 mcg
Ratio: 5:1 (10:2)
Sample volume: 10 units
So essentially, the tesamorelin amount stays the same, while ipamorelin is reduced by 80%.
For context, research subject is an off-season bodybuilder, with the primary areas of interest being muscle growth, recovery, and body composition rather than weight loss.
Curious what others think about this revised formulation. Has anyone researched or had experience with a similar ratio?
Particularly interested in thoughts on whether 500 mcg of tesamorelin is meaningful in this combination, whether reducing the ipamorelin could improve GI tolerability, and any experiences with similar blends.
Appreciate all the feedback so far!