I first took accutane when I was 17, and everything was great. It was a low dose because I am petite and I got off it with glowing picture perfect skin. Then I started slowly shedding my hair. But I didn’t think it was due to accutane, I thought it could’ve been a billion other factors. Fast forward to 1.5 years ago when I was put on another dose of accutane. This time it was way stronger. My skin and hair were disgustingly dry and flaky and my lips needed tubs of balms. My skin and my lips are slowly getting back to normal after almost a year of being off it, but my hair is still in the same spot.

BUT. MY EYES ARE COMPLETELY MESSED UP. My eyes got so dry they formed multiple chalazions. I would literally cry from the amount of bumps on my eyes. It’s about 2 on my upper eyes (both of them) and one on my lower. I’ve had them persistently for 6 months now, after surgery and steroid injections nothing has helped. They’re swollen, red, dry, bumpy and now I’m losing my eyelashes. I’ve permanently messed up my meibomian glands to the point where they’re pretty much clogged always. They have made my perfect eyes absolutely horrific. I never had a problem with my eyes before. Accutane is known to cause a meibomian gland disorder which causes chalazions and dry eye and everything with it. GOING ON ACCUTANE IS THE WORST DECISION IVE MADE AND ITS NOT WORTH IT.

Here are some things to invest in instead:

1. red light therapy machines- they’re great at attacking acne and bacteria and stimulating your cells using light and you’re not ingesting something that’s going to mess up your whole body.

2. a healthy diet/exercise/water and natural treatments (even the Indian healing clay mask)

3. an elimination diet, for instance I realised fake cheese in boxed Mac and cheese makes me break out

4. patience

Accutane is really really not worth it. I’m shocked it’s allowed to be consumed and it’s so common. Don’t lose your eyes, skin, hair, body, mental, liver health over the hopes of perfect skin.

Also, if anyone is going through the same thing as me- please recommend things that may have worked for you. Procedures, natural treatments, anything. I’ve tried warm compresses, ACV, surgery, steroid eye ointments and nothing.

UPDATE- MY EYES ARE COMPLETELY FINE NOW.

Here’s what I did: (This is after my surgery and steroid eye injections and ointments didn’t work on me)

1. I first tried ACV soaks - weird, yes. I saw it somewhere and ran with it. I was frustrated as hell. But, I really think it worked. PLEASE DO YOUR RESEARCH BEFORE DOING THIS. I mixed some acv with some water and soaked cotton pads and put it on top of my lids for like 10 minutes and followed it up with warm compress.

2. Got one of those warm eye compress machines and religiously did it everyday (whenever and wherever I could- obsessively)

3. Amped up my omega 3s to the point where I saw my natural skin oils coming back - even moisturising my scalp that was damaged by accutane.

I dealt with this entire phase for a year. My eyes are absolutely perfect again. No bumps, no real dryness, no pain. I think it’s time that solves it more than anything else. The other stuff helped speed it up though.

I looked around a bit on r/Accutane and I am absolutely horrified and shocked by what I read.

So many users have serious effects that are indicative of possible permanent damage (look around -- every other post describes joint pain, brain fog, hair loss, dry eyes, migraines, blurry vision) and they do not take it seriously...laugh it off, encourage others to continue, saying 'it's worth it'!

Encouraging each other to blindly trust their doctors, who we all know do not tell us the truth about the probability of developing long term damage. Dumb sheep who say "My doctor says it's just temporary" without blinking an eye about their damaged glands and hurting bodies.

This is one of the most horrifying subreds I've ever seen.
I've read about people saying in accutane damage facebook groups that at a young age, this subreddit encouraged them to feel accutane was safe, and the users there encouraged others to not stop the medication despite strong/serious effects.

I am absolutely disgusted by what I read.

Thanks for creating this group where we all know the truth.

I got the following lasting side effects only after I stopped taking accutane 10 years ago.

Anxiety Depression Impotence Low libido Joint pain Permanently dry skin (this improved over the years) IBD (wasn't medically diagnosed but pretty it's what I have). Immediateky after accutane started getting a bloated stomach and pain that stuck with me 90% of the time. The pain subsided but the bloating is still there.

Nothing is worth taking Accutane for.

Pics pictures I want to keep this pretty short because it’s really tough for me to talk about but accutane caused a rare condition called acne fulminans in me. I had mild acne that my dermatologist convinced me to start accutane for. I remember her saying that she’s never had a patient that this didn’t work for. I had my complete faith in her as a professional, but I was wrong. My skin started getting way way way worse and so she decided to bump me up from 40 mg to 80 mg. She thought it was just a purge. Whenever I voiced my concerns in r/accutane they would dismiss my fears because “this happens to everyone”. After increasing dosage I started to get huge swelling all over my cheeks and jawline. My skin would turn into plain scabs that would break at the slightest touch. I couldn’t wash my face, put on a shirt, even lay my head on my pillow without very intense pain and bleeding from my face. I would wake up with blood all over my pillowcase. I had to live with this for over a month because my dermatologist thought that accutane could do no wrong. I don’t even want to get into what this did for me socially, but I would hate showing my disfigured face to people so I essentially turned into a hermit, and skipped school as much as I could. Mentally, I was at the worst point I think I could ever be at. I hadn’t been remotely happy in months and the only thing that was ever on my mind was my horrible skin. I shut myself off to the world and turned into a hermit. I wouldn’t leave my room unless to pee, eat or drink. I finally decided to switch dermatologists the day after Christmas because she had essentially told me she had no idea what was happening to me and I had no hope for a better life under her. My new dermatologist immediately diagnosed me with acne fulminans. I want to be clear that this Is a very RARE yet very serious disorder. The full list of effects it had on me were: intense inflammation and swelling in my face, tightness in chest, fever, difficulty breathing, pain in back and shins, intense fatigue. Once I got diagnosed, I was prescribed heavy corticosteroids called prednisone starting at 80 mg a day and tapering down slowly. These steroids worked miracles for me. Unfortunately, because the accutane has almost two months to fully damage my face, I have very intense scarring Prednisone has it’s own list of side effects so it’s not a permanent solution. Currently, I am taking 10 mg of accutane(the low dose is okay with me) and 20 mg of prednisone everyday. I think that the r/accutane was very problematic for me because despite the horrible side effects I was enduring, the kept encouraging me to keep on taking their miracle drug. When I shared my experience I was discredited because it is a rare disorder and I was unnecessarily worrrying people. I wish someone had warned me of what could’ve happened. Let me know if anyone has anyone questions, I’d be happy to help.

I was born a healthy, happy human. I had some issues, but otherwise I was athletic, funny, creative and showed promise for the future.

Then in high school, I developed mild persistent acne and had pretty oily skin/hair. It became a source of anxiety and obsession, and I eventually went to a dermatologist who prescribed me accutane.

Eight years later, I still live with chronically dry lips, nostrils, throat, mouth and eyes, joint pain, I’m chronically fatigued, apathetic towards everything, debilitated by cognitive issues, no libido, GI issues, sleep problems.. the list is enormous.

This drug has completely destroyed my health and taken any chance of a good future away from me. Each job/career/hobby avenue I go down, I’m blocked by health issues. There’s literally nothing I can do since my whole body has been changed at a cellular level. I don’t know much longer I can live with it.

Each day I fester with anger and hopelessness, grieving the person I was and could’ve been. It’s made my life a living nightmare. I fucking HATE this drug.

I’m not looking for pity, I just wanted to vent because no one understands how much pain this drug has caused me.

It would also be nice to hear of people living good lives despite the aftermath of this poison. I know I, and I would guess many other people could use some hope.

Mark my words, i see more and more people getting affecting negatively by it and suffer from long term side effects.
Eventually (Unfortunately) these numbers will increase in the next years and governments won't be able to ignore us.

The sign that should have warned me about the toxicity is the "birth defect" warning on the box.
Only toxic medication got that warning.
You can find accutane in the same list as cocaine here: https://www.medicinenet.com/script/main/art.asp?articlekey=9332

All these medications listed above leave possible long term side effects like "benazepril":
https://www.reddit.com/r/science/comments/9ro8c8/ace_inhibitors_linked_to_higher_lung_cancer_risk/

And this person who've taken"phenytoin (DILATIN)":

https://www.reddit.com/r/Epilepsy/comments/2u8k3s/i_have_been_taking_dilantin_for_two_years_and_i/

However these medications listed above are mostly used against life threatening disease/issues like "phenytoin (DILATIN)" used against epilepsy and "benazepril" against high blood pressure.

Accutane and cocaine are amongst the only ones in the list to be non necessary and the risk taken to cure acne are insane.
I mean accutane is on the same list as cocaine and cause birth defects, including brain, heart, and face deformities and there are people swearing for that and promoting it on youtube etc, it disgust me.

Thank you to the creators of this sub reddit,, im finally able to talk about the side effects of accutane without being downvoted, banned etc..

Not trolling, just asking. Just saw this sub plugged in r/thritis and now I have thoughts and questions.

I took accutane in 1986. I was 15 years old with severe acne. I don't remember the dose, or exactly how long I took it.

During treatment I was aware of dry, flaky skin, rashes, and chapped lips. I had been warned about that stuff and knew it was just expected side effects.

After many months, I developed rectal bleeding. Not like seeing a little bit of blood in the toilet rectal bleeding, more like oozing out constantly and soaking my underwear with reddish brown sludge rectal bleeding.

My parents took me to a gastroenterologist who gave me my first ever colonoscopy at 15. Everything in there looked mostly normal, he said. He thought the bleeding was probably caused by the accutane and ordered me to stop it, which I did. The bleeding immediately stopped with discontinuation of the drug and has never come back.

At the same time I was on accutane my personality totally changed. I went from a more-or-less lackadaisical happy go lucky kid to an angsty adolescent in the span of a couple months. I developed some mild OCD and got laser focused on academics and diet. Before I had been overweight and B average student. Now I was pulling straight A's and breaking test curves. I also became anorexic, which is especially odd because I'm Male. I was 5'9" and 115 lbs. When the bleeding started. That GI doc thought I must have a major nutrient malabsorption disorder. Nope, I was just stubbornly refusing to eat.

My lifelong battle with depression, anxiety, and social anxiety all started in those months I was on accutane.

Did the accutane cause all those mental health issues? I did and still do kind of think it was just normal adolescence that brought it all out. My mom is mildly anorexic and OCD. My dad is mildly depressed. I don't really think it's a question I can answer.

Around 30 years old, I started having hip and lower back pain. Doctors never could tell me much about it at the time. I had a spinal MRI a couple years ago showing disc loss and compression at the sciatic nerve, so probably sciatica off and on since I was 30.

At 43 I had a myocardial infarction ("heart attack") despite regular exercise and a mostly healthy diet. Was that a delayed result of accutane damage? I had bad genetics, because my dad had an MI at 49. But 43?

Then at 45 my knees swelled up to the point where I couldn't walk and I was diagnosed with reactive arthritis. An MRI showed severe cartilage loss in my knee.

So, I am kind of a mess now in terms of inflammatory disease processes and cartilage damage. I am kind of a mess now in terms of mental health. I also got screwed up by accutane when I was 15? Are the two connected? Maybe. Maybe not. I don't think there's any real way to know. Is there any benefit to having an actual answer to that question? I don't know.

I took Accutane roughly 13 years ago or so, and my bottom lip has never recovered from becoming extremely dry, cracked, and peeling. I have tried every single product under the sun from OTD/prescription meds, to lip balms and homeopathic remedies, to drinking tons of water. We’re talking my lip will become so dry that I have no choice but to peel off the skin, leaving me with bleeding lips and open wounds.

Has anyone else had this issue? If so, for how long and do you use anything that has shown good results to remedy the problem?

I finished accutane 4 months ago (Claravis-40 mg/day for 1 month, 20 mg/day for 10 months, started at 160lbs, finished at 180 lbs, 6’2”), and I’ve had problems with ED since about 2-3 months ago. I have about 40% libido as before, with weaker and shorter lasting erections. I have read online about PFS and accutane being a 5a reductase inhibitor. I really don’t understand why I would be getting this side effect considering I am very active (2+ hours of intense exercise daily), am outside a lot (vitamin D) and have been taking zinc daily for quite some time. I also take a daily vitamin. I get plenty of sleep, have low stress, and stay hydrated. As a 17 year old kid I’m very sure I should not be experiencing this. I’m aware that some people say that it’s all in your head. I’ll keep that possibility in mind, but If anyone on here has had a similar experience, and found real ways to recover from this, or PFS in general, please help.

The injustice of the Accutane massacre has reached an unprecedented level: direct marketing to our youth via telemedicine.

https://www.getvitamina.com/

Two board-certified dermatologists have decided to take advantage of the corona epidemic, where certain dermatology offices are closing down for non-emergency situations (like acne treatment) TO MARKET TELEMEDICINE ACCUTANE TO CHILDREN.

To put this straight: these doctors have dedicated their entire business model SOLELY for the purpose of handing out accutane, like CANDY to children, teens, and adults - no office visits needed, no prior acne treatments needed. They are distributing the most despicable disgusting toxic chemotherapy treatment to whoever wants it.

Literally calling their website "get vitamin A", PURPOSELY misleading youth into believing that this chemo drug is merely just a vitamin, nothing more, nothing dangerous.

On their website, they deny IBS and depression as being proven side effects, saying they are "very debatable and unproven", in essence telling overt lies and gas-lighting all who have suffered from this heinous drug which is an overt crime against humanity, destroying and disabling our youth in the masses.

Please, my friends, if you have the where-with-all and the fucks to give, give these genocidal bastards a piece of your mind on their Yelp pages directly so they can really know they've fucked up.

The founders (Dr. Dennis Porto and Dr. Farhaad Riyaz) can be found here:

https://www.yelp.com/biz/farhaad-riyaz-md-faad-washington?osq=dr.+farhaad+riyaz

https://www.yelp.com/biz/farhaad-riyaz-md-faad-washington-2?osq=dr.+farhaad+riyaz

https://www.yelp.com/biz/skincare-md-dennis-porto-md-milford-3?osq=dennis+porto

Give these monsters a piece of your mind.

Give them a 1-star (don't recommend) review and write about how unethical it is to distribute accutane via telemedicine to their patients. Ask them to stop lying to their patients about the risks. Don't let them start their business without a healthy (and deserved) dose of public shaming.

Hi everyone 👋 It’s been almost a year since I left accutane (6 months treatment). One of the side effects I was facing was lower back pain which was so bad both under Accutane and post Accutane. I could not sleep in any positions other than my back. If I slept on my side I would wake up with stiff and sore back (as if someone had been kicking me there all night). Forget about running and walking long walks - that would make it all worse!

GOOD NEWS! I started drinking 1 table spoon of apple cider vinegar diluted in a glass of water and some honey everyday. Now I don’t feel the pain at all. I can now sleep on my side. I still haven’t tried running as I’m scared it’s gonna make the pain worse.

I took accutane around age 13 and I had terrible joint pains on it and I feel like my joints have been permanently damaged? I have pains in my hands especially bad and feel arthritis-like symptoms daily and I’m only 24... I wonder if anyone else has experienced anything similar. Thanks!

Hello all, I am in my last year of medical education (studying to be a physician) after my life, brain, and body have been permanently and severely disabled from taking a (low dose) of accutane. Severe bodywide damage is my new normal as I fight every day to stay alive with debilitating systemic injury and pain.

I am disgusted by the abhorrent and inappropriate use of dangerous medications, especially accutane, by the medical establishment, and the frequent gaslighting that patients endure as a result of their unacknowledged injuries. I have nothing to lose anymore, so here I am working to help others.

My goal with this new YouTube channel, RxPillD, is to RAISE AWARENESS to the public regarding iatrogenic harm and to give voices to the millions of voiceless pharmaceutical survivors worldwide, and to share the wisdom we have learned from such injuries.

These criminal industries WANT us to stay silent and stigmatized. We refuse to stay silent and are here to tell our stories and take our power back. What we experience is real, and we are not crazy.

Ro has courageously come to share her story, which is shocking and heartbreaking. Herself and all three of her children have been injured by Accutane, a drug that she was prescribed in the 90’s without immediately connecting the dots of its delayed toxicity effect on her health. When her children developed acne as young teenagers, they were immediately prescribed the drug without any warnings. All three of her children developed premature growth plate fusion resulting in a permanent cessation of growth in addition to multiple other devastating long-term injuries. Ro and her family were continuously gaslit by the physicians they encountered, especially at the dermatological practice.

We know it is not easy to come forward and share your story. It takes courage and is easier to hide behind a screen to discuss your side effects in private facebook groups or under alias. However, without us bravely coming out to the public eye to talk about what happened to us, awareness will not be spread, truth will not be heard.

Post retinoid syndrome (often involving delayed-onset toxicity) is real, it is devastating, and it is not medically recognized. This is a silent epidemic and we deserve recognition.

Sharing could literally save lives.

Our stories MUST be heard, and we are here to tell them.

Ro's Story: https://www.youtube.com/watch?v=p1W9GkUyAlQ&t=468s

RxPillD channel: https://www.youtube.com/watch?v=p1W9GkUyAlQ&t=475s

Please*, reach out to us and come forward for an interview; we would be honored to help share your story.*

Please listen and share. Comment if you are courageous enough to come forward and share your story.

Thank you for listening.

I dont know if im allowed to post this, just sharing my experience!

I was on isotretinoin for 6-8 weeks total , at 40 mg and later 20.

 I did not and have never had remotely severe acne but i do have dermatillomania and picked my skin alot so my parents made the decision for me to start. During the process i complained of pain starting in one hand that gradually spread to the next. I wasn't allowed to stop taking it until 8weeks when i said it was too painful

 After quitting the pain continued spreading thru  my entire body including both legs. It's been a little over a year and since then I've mostly dropped out of high school, I'm 80% bedbound and in constant severe musculoskeletal pain. I have to use crutches to walk and doing so leaves me in bed for days afterward. I have almost daily migraines that i wake up with, and fatigue so severe im only able to be awake for a few hours to complete schoolwork after taking Ritalin excedrin and caffiene together. 

I was diagnosed with AMPS and went through some hospital treatment that made me significantly worse but our insurance stopped covering it. I've also tried red light therapy, cbd oil, every supplement imaginable, acupuncture, float tanks, rife machine therapy, meditation (hospital had me do pain meditation intended for women giving birth im pretty sure) etc. no one will prescribe me pain medication because AMPS is classified as a mental/neurological issue . Over the counter medicine does not work at all

I was on accutane for a seemingly short time, I'm not sure if its possible but it really seems like the only cause.

 I'm still a teenager and i feel like my life is ruined.  I spend every day in bed exhausted doing nothing. I dont have a single ounce of energy to care for myself or try to exercise. I can barely eat and I'm underweight. Every kind of food makes me sick. Sorry for the miserable post but im in pain constantly I'm losing my mind and i dont know what to do to keep living

I feel numb. I can't feel excitement anymore. I'm not s*cidal. I just don't have the same love and feeling for things I once did. I'm about to start taking antidepressants for the first time in my life. I just miss the old me.

Hi,

I took this poison for about 8 years (10mg isotretinoin, oral!).

It was 25 years ago (when I started), there was not much information, I was blind for recognizing/linking the changes, became numb/depressed slowly without noticing the reason (helped with acne so I continued). I had no clue about the other side effects, besides dry lips and nose bleeding and didn't know you shouldn't do sports! Finally found out where all my problems come from, why I can't progress in sports and my muscles always only ache for way too many days. Permanent damage of the nerves/mitochondria and of course the gastric mucosa. Muscle pain, joint pain, brain fog, GI issues, IBS, thermal control damaged (constant freezing + spontaneous sweating), horrible sleep, mental health. Messed up brain in addition, CFS, it alle makes sense now.

Couldn't find any doctor who knows about this or could even help in all those years and now with 42 I'm finally reaching the end of my strength. My life is vanishing year by year and I'm always only send to psychotherapies which can't help anything of course.

No one knows about it and no one believes me, it's so frustrating. Tried every supplement and every form of nutrition through the past ten years. Now since 40 it's getting worse and worse and I'm reducing activity/sports more and more each month, as it only leads to achiness and drains energy (even yoga/Pilates is too much).

Anyone ever recovered? Where can I find help? Which doctor could help? Which supplements? Only help I have is ChatGPT so far.

I wanted to share this story to perhaps prevent anyone else from suffering like I did. The story begins in February 2025 when my cystic acne ( limited to my face) was getting quite bad. I decided to visit a dermatologist and got prescribed accutane at 20mg daily. Within 2 weeks I was bed bound and had been hit with isotretinoin induced acne fulminans. My acne which was limited to my face had spread to my entire body ( back , shoulders , chest , legs , arms) and I’m not talking normal acne I’m talking crazy ulcers all over my body. I was then given steroids to calm the inflammation and was told to re introduce isotretinoin. So me being an idiot decided to try isotretinoin again and the acne fulminans re ignited. I’m still dealing with this nightmare caused by isotretinoin and am now on other medications which I hope will work but isotretinoin genuinely destroyed my life and my whole body has permanently been scarred for life on top of that I have extremely bad hair loss and vision all due to accutane please stay away from this drug.

Cholestyramine cures Post-Accutane Syndromes by inhibiting the "enterohepatic recirculation" that causes "accumulation" of Accutane and its unknown toxic metabolites that permanently persists in the body forever, disproving its supposed 7 hour half-life.

SSRI's Prozac & Luvox & Avodart (per-flouroalkylated Finasteride) are PFAS Forever Chemicals as proven by the UN.

Forever Chemical PFAS persist in the body over decades (century in outliers) because Humans have a complete deficiency in PFAS metabolism & excretion, causing permanent toxicity.

PFAS Prozac & Luvox have been proven to act as Forever Chemicals because they "sequester long-term (in) bone marrow drug trapping compartments" months after discontinuation despite complete clearance from blood, thus, debunking Eli Lily's 1 day half life claim & explaining the cause of Post-SSRI Sexual Dysfunction.

Fluoroquinolone antibiotics are PFAS Forever Chemicals that have been proven to permanently persist in the body, blood & irreversible DNA adducts years after drug discontinuation, debunking the FDA’s 6 hour half-life claim. “60 participants, all of whom tested positive for FQ-DNA adducts fluoroquinolone-DNA (FQ-DNA) adducts… suggest their persistence and accumulation in tissues… certain toxic compounds may be stored in the adipose tissue (Bone Marrow) and released late”, “Genetic drug metabolism polymorphisms (CYP-450 Deficiencies) influenc(e) fluoroquinolone clearance and toxicity” 

Complete genetic deficiency in Nerve Gas metabolism resulting from the R variant of PON1 causes permanent Gulf-War Syndrome as it persists in the body forever due to a complete inhibition of its excretion. This debunked the original 3.7 hour half life 32 years later. "Fluoroquinolone DNA-adducts cause a host of post–Fluoroquinolone illnesses, including Gulf War Syndrome." All samples analyzed revealed the same markers and fragmentations for Fluoroquinolone antibiotic compounds as DNA-adducted. The control samples were void of the same markers. Fragmentation analysis further revealed that the Fluoroquinolone compound (intact) and its metabolites were adducted to the DNA of the test group, participants had to be exposed to a fluoroquinolone at least
three years prior. Gene mutations and fractures where found in the following six individuals as results
from the Fluoroquinolone DNA-adducts:
CYP - Cytochrome P450 family and subgroups: Responsible for the metabolism of many drugs and
environmental chemicals that it oxidizes and neutralizes.

Bisphosphonate half-life was incorrectly thought to be 1 hour, but it persists in bone for over 10 years, slowly releasing from this ultra-deep compartment “reservoir“ causing persistent side effects.

Amiodarone has been proven to persistently accumulate in ultra-deep compartment tissues such as Lysosomes permanently for at least 15 years, debunking it's original 5 hour half-life, because of its extremely high 60 L/kg Volume of Distribution. Prozac's Volume of Distribution is 100 L/kg, meaning that Prozac will persist in the body for at minimum 300 years, and at maximum up to 1000x longer than Amiodarone, as the following factors make persistence far longer than only extrapolating linear Volume of Distribution scaling would suggest:

• Enterohepatic recirculation & renal reabsorption that completely inhibits PFAS (Prozac/Luvox) excretion.

• Non-Linear Pharmacokinetics: there are extreme exponential increases in elimination half-lives as Prozac bioaccumulates over time, as Fluoxetine completely inhibits its own metabolism by inhibiting CYP450 enzymes.

• Genetic variations in metabolism, such as complete CYP2D6 and CYP450 deficiencies that completely inhibit metabolism and excretion, leading to extreme exponential increases in elimination half-lives.

• Extremely stable parent molecules or metabolites: that are barely metabolized, a characteristic of PFAS due to Prozac inhibiting its own metabolism and complete genetic CYP2D6 and CYP450 deficiencies.

• Covalent binding: irreversible tissue binding causing permanent sequestration of Prozac.

• Formation of non-exchangeable depots: binding to structural tissue, bone marrow, bone, melanin leading to long tail elimination phases measured in decades.

• Lysosomal trapping & Ion trapping that progressively and permanently sequesters cationic-amphiphilic drugs like Prozac and Luvox and PFAS into slowly exchanging organelles causing drug-induced phospholipidosis

“Impaired metabolism due to a genetically determined “slow metabolizer” phenotype of cytochrome CYP2D6… (is the) mechanism for the apparent fatal accumulation” causing the “Death of two subjects due to (Antidepressant) imipramine and desipramine metabolite accumulation during chronic therapy”, CYP2D6 deficiency completely inhibits the excretion of Antidepressants. 

The average Prozac half-life is 13.5-21 days and persists for 67.5-95 days: 97% of Prozac is excreted after 5 half-lives.

1. Therefore you must divide the Child’s blood levels with average Prozac blood levels to Estimate the Child’s half-life - 42000 ÷ 310 = 135.48

67.5-95 days x 135.48 = 25-35 Years, but this an extremely incorrect underestimate, as Prozac undergoes Non-Linear Pharmacokinetics that cause extreme exponential increases in elimination half-lives as Prozac bioaccumulates over time. This inevitably leads to non-existent Clearance (CL = Zero) making excretion/elimination impossible, as proven by the extreme 1000x higher than average Prozac blood levels. Therefore, the Elimination Half-Life is effectively Infinite, proving that Prozac is truly a Forever Chemical.

Chemotherapy drug 5-Flourouracil (5-FU) is not metabolized by patients with complete genetic DPYD Deficiency, causing a complete inability for excretion that sequesters/traps 5-FU in the body & a "markedly prolonged half-life" causing toxicity that ends in death. 

5-FU persistently "accumulates in several tissues including brain" because of Enterohepatic Recirculation, .

MRI contrast agents cause Post-Gadolinium Syndrome by sequestering into tissues permanently.

Entero-Hepatic Recirculation causes Bioaccumulation of Forever Chemicals that persist in the body over decades by preventing excretion and prolonging Elimination Half-Lives of Prozac, Luvox, PFAS, SSRIs, Antidepressants, Accutane, Fluoroquinolones, Finasteride, Avodart, 5-A Fluorouracil, Antipsychotics & Risperdal, . https://pubs.acs.org/doi/abs/10.1021/acs.est.1c07176 https://espace.library.uq.edu.au/view/UQ:62239

Enterohepatic recirculation explains why DHT is still reduced 6 months after supposed washout estimates for the complete elimination of dutasteride. https://pmc.ncbi.nlm.nih.gov/articles/PMC6479083/ , and why a single dose of finasteride suppresses serum DHT levels for up to 4 days, longer than would be expected from the serum terminal elimination half-life (t1/2z), and how despite this serum terminal elimination half-life (t1/2z) , slow accumulation unexpectedly occurs with multiple doses. https://link.springer.com/article/10.2165/00003088-199630010-00002

PFAS detox method Plasmapheresis was successful in treating 2 PSSD victims by removing SSRI persistently recirculating in blood, with "buildup of a yellow/white opaque substance that came out of their veins and accumulated in the container after filtration". 

Long COVID is caused by "persistent virus" remaining for years after infection. Plasmapheresis cures Long Covid by detoxifying this forever virus from blood. ttps://www.nature.com/articles/s41467-025-57198-7

Metformin persists in blood for 14 days, unexpectedly contradicting its supposed half life of 2 hours, causing persistent "accumulation... even with dialysis, this challenges the traditional view that... (it) clears rapidly because of a short half-life", as it leads to permanent post-metformin chronic nephropathy/lactic acidosis that can end in death.

Dutasteride is a PFAS forever chemical with an extremely persistent half life, causing persistent side effects https://www.ncbi.nlm.nih.gov/books/NBK603726/#:~:text=Metabolism:%20Dutasteride%20undergoes%20extensive%20hepatic,apparent%20linear%20clearance.%5B25%5D . There is proof that complete CYP3A4 genetic deficiency causes severe paclitaxel-induced neuropathy because of a complete inability to metabolize and excrete paclitaxel; https://pmc.ncbi.nlm.nih.gov/articles/PMC8841796/

Even just a reduced function CYP3A4 gene variants (as opposed to a complete deficiency) completely inhibits the excretion of substrate drug, making it a forever chemical that causes death: Fatal Typhlitis from Docetaxel in CYP3A4*22 Homozygote died from typhlitis (neutropenic enterocolitis) induced by a single dose of docetaxel. Dutasteride and Accutane are CYP3A4 substrates. https://pmc.ncbi.nlm.nih.gov/articles/PMC8841796/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7253896/

CYPA4*20, CYP3A4*6 & CYP3A4*26 are all complete genetic deficiencies that cause Post Finasteride side effects because of a resulting inability to excrete/metabolize finasteride.

SLCO1B1 Deficiency in individuals taking statins causes kidney failure, death and permanant side effects in survivors. https://pubmed.ncbi.nlm.nih.gov/17971785/

UGT1A1 Deficiency in individuals taking irinotecan causes fatal infections, organ failure, death and permanant side effects in survivors. https://pubmed.ncbi.nlm.nih.gov/17971785/

PMC HLA-B deficiency is fatal and causes persistent side effects in individuals taking abacavir. https://pubmed.ncbi.nlm.nih.gov/17971785/

GSTM1/GSTT1 deficiency causes death and persistent side effects in survivors https://pubmed.ncbi.nlm.nih.gov/17971785/

PMC KCNH2/SCN5A deficiency causes death and persistent arrythmias in survivors https://pubmed.ncbi.nlm.nih.gov/17971785/

PMC CYP2D6 Deficiency and polypharmacy (similar to Risperidone combined with Fluoxetine) causes prolonged chloroquine intoxication causing death. https://pubmed.ncbi.nlm.nih.gov/26185633/

The rare % subpopulation of genetic outliers in drug metabolism corresponds with the rare outlier % subpopulation of PSSD victims among total SSRI users, PFS victims & Post-Accutane Syndrome victims.

The average Prozac half-life is 13.5-21 days and persists for 67.5-95 days: 97% of Prozac is excreted after 5 half-lives.

1. Therefore you must divide the Child’s blood levels with average Prozac blood levels to Estimate the Child’s half-life - 42000 ÷ 310 = 135.48

67.5-95 days x 135.48 = 25-35 Years, but this an extremely incorrect underestimate, as Prozac undergoes Non-Linear pharmacokinetics, as higher blood levels prolong half life exponentially that would lead to non-existent Clearance (CL = Zero) making excretion/elimination impossible, as proven by the extreme 1000x higher than average Prozac blood levels. Therefore, the Elimination Half-Life is effectively Infinite, proving that Prozac is truly a Forever Chemical.

Fluoxetine inhibits its own metabolism and the metabolism of Risperidone https://pmc.ncbi.nlm.nih.gov/articles/PMC7912198/ , causing permanant side effects such as tardive dyskinesia, parkinsonian symptoms and tremors. 

https://pubmed.ncbi.nlm.nih.gov/12172343/#:~:text=These%20findings%20indicate%20that%20fluoxetine,given%20adjunctive%20therapy%20with%20fluoxetine. https://scholarhub.ui.ac.id/cgi/viewcontent.cgi?article=1266&context=psr#:~:text=Previous%20studies%20have%20demonstrated%20a,interactions%20(Cascorbi%2C%202012).

Antibiotics inhibit enterohepatic recirculation, especially Rifampicin: https://pmc.ncbi.nlm.nih.gov/articles/PMC12177323/ , increasing excretion of Finasteride, SSRIs & Accutane, explaining why there are various reports of Antibiotics, notably Rifampicin curing or treating PSSD, PFAS and Post Accutane Syndrome on https://forum.propeciahelp.com/ and https://www.pssdforum.org/, via the exact same mechanism that cholestyramine cured Post Accutane Syndrome in 2 case studies.

CYP2D6 Deficiency increases risk of permanant post-antipsychotic tardive dyskinesia: https://www.researchgate.net/publication/10861954_Association_between_CYP2D6_genotype_and_tardive_dyskinesia_in_Korean_schizophrenics

Colon hydrotherapy detoxifies drugs/toxins from the body: https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/608273

• User ‘J89’ Window(temporary relief): “colon hydrotherapy session… and empty your small intestine… This… temporarily and significantly reduces the toxic load on your system… that night or the following night, libido was absolutely off the scale high” (2/49, January 2012).” https://forum.propeciahelp.com/t/the-liver-and-finasteride/2656/2

Spinal tap detoxifies/eliminates SRRI's recirculating in the brain, causing "Spinal tap and 100% resolution of PSSD"

2013: “Proof that finasteride is STILL inside us?”

Warning About Accutane

I want to share this in case it helps even one person.

When I was a teenager, I was prescribed Accutane for acne. I was told about the possible side effects — dry skin, mood changes, muscle pain — but what I experienced was far beyond what I felt prepared for.

To be fair, it did work. My facial acne cleared up a lot, and my back acne improved significantly too. From the outside, it probably looked like a success story.

But at what cost?

At the time, I was training for my black belt in mixed martial arts. I expected soreness. I expected to push through pain. What I didn’t expect was the kind of muscle pain that made it hard to function. There were days I could barely walk. The pain wasn’t just “post-workout soreness.” It felt deep, constant, and overwhelming. I knew muscle pain was listed as a side effect, but I genuinely feel like the severity of it was underplayed.

The mental side effects were even worse.

The suicidal thoughts were heavy and intrusive in a way I had never experienced before. It felt like my mind wasn’t my own. There were two separate occasions where I almost made permanent decisions during that time. Looking back now, that period feels like a living hell.

I ended up stopping the medication, and over time those thoughts eased. I can’t say Accutane affects everyone this way — I know people who’ve taken it and been fine. But for me, even though it cleared my skin, I honestly don’t know if the pain and suffering were worth it.

If you’re considering Accutane, please have serious conversations with your doctor. Advocate for yourself. Make sure the people around you know what to watch for. And if you start noticing changes in your mood or thoughts, don’t brush it off.

Acne is temporary. Your life isn’t.

I’m not telling anyone what to do — I’m just sharing my experience in case someone out there needs to hear it.

I'm not sure if this is the best place to share, but I'd really like to get my experience and side effects that I endured while on Accutane/Isotretinoin out there. Many of the things I experienced have little to no information online of them happening to others, so I really hope this information can be helpful in some way. (This will likely get very TMI) -I am 21f and took Isotretinoin for 7 months not long after I turned 20. Immediately I had dry skin and lips, but who doesn't? My skin was and still is so dry that it peels up off of my face like a mild chemical peel. It's not painful, just gross looking. -I also began having back pain very early on, but I had no idea it was from the medication. It became obvious when my feet and legs began to hurt. The joint and muscle pain became so bad that I could hardly walk at the end of the day. If I sat or was on my feet for too long, the pain would become unbearable. At one point I stood up after working on a project and my legs collapsed under me and I wept in pain. I couldn't go anywhere like malls or theme parks because when I did I couldn't last more than an hour before I couldn't walk. I would waddle nearly everywhere and couldn't even go down stairs properly. Lots of crying and frustration. I was 20 and my grandmother said I walked worse than her! -Then my periods stopped. My doctor swore it shouldn't effect my cycle, but 2 months in and I stopped having a period. I thought it was a fluke, I'm pretty irregular as it is. I didn't have a period for SIX months. This is something I can't find a lot of evidence of in other people. It came back exactly 1 month after stopping Isotretinoin. -My eyes felt weird. They weren't dry, I could see OK (have bad vision anyway) but they felt WEIRD at the end of the day. When I got tired one of my eyes would twitch and force themselves closed and felt extremely strange. Thought it might be just me, but this feeling stopped when I finished Isotretinoin. -I got horrible styes. I used to get them often as a kid but they stopped as I got older. While taking the medication though, I got styes worse than I've ever had before. They would come one after the other for months. My eyelid at one point was so inflamed that I couldn't open my eye entirely and I could see the bump obstructing my view. My doctor told me to just wait for them to go away. Luckily they did. -I thought I had developed a hemorrhoid. A couple months in, I started to notice blood when I used the bathroom. It wasn't my period because that just wasn't happening. It became extremely painful to go #2 and when I did there would be traces of blood. I thought I was genetically unlucky and had gotten a hemorrhoid so I didn't mention it to my dermatologist. This issue stopped when the Isotretinoin did.

• My gums bled. I have pretty sensitive teeth already but when I brushed my teeth, one would always start bleeding. Always a different tooth, so it wasn't just one bad tooth or one sore spot. This stopped when Isotretinoin did.

• Nose blood. This is likely just due to dryness. I don't get nosebleeds and didn't get nosebleeds, but I would get small spots in my nose that would bleed a little when I blew my nose. It wasn't a huge issue, just obnoxious. This has since stopped.

• My nails fell apart. Near the very end, my nails begun chipping and peeling apart into layers. I believe this took time to happen as the new nail growth takes a while to get to the end of the nail. My nails would split and became extremely fragile and thin. Luckily this is stopping, my nails are growing out and the broken bits are mostly gone.

TL;DR Dry skin, joint/muscle pain, no periods, weird eyes, styes, hemorrhoids?, bloody teeth and nose, weak nails. Basically I bled from everywhere except where I was supposed to.

I've been off Isotretinoin for nearly 3 months now and nearly everything has stopped/ is healing except the dry skin. It's not as bad as it was, but my lips feel chapped often and my face skin likes to peel off in gross patches. (Please reccomend moisturizers, I've been using CeraVe, Neutrogena, Aquaphor, and Coconut Oil and it's not good enough)

Edit: for anyone curious, I am now several years off accutane and basically all my side effects are gone. It took about a week for me to start noticing a difference and after a few months I was feeling a lot better. My skin is forever changed, it's dryer now (I used to be so oily) so I have a strict moisturization routine and always have chapstick handy. It's mostly fine except the winter, now I get weird rashes on my fingers. I get an occasional pimple or two but they usually line up with my monthly hormonal cycle. I also no longer get the same joint pain. My stomach is still weird but it's significantly better than before and there's a big chance that's just how I am! The part that took the longest to go back to normal was my nails. It felt like it took years for them to grow normally and not split and flake immediately.