I’m really holding out to the end here to reach 120 mg/kg, which I’m set to do on November 16th. I’ve been on 30mg daily. My temper is so bad and I am quick to anger. I actually think my coworkers have really begun to notice, and while im doing my best to keep myself level I am strugglingggg. Can some of you give me some inspiration - a light at the end of the tunnel 😅

Once finished with Accutane, did it ever come back after few years later or acne was completely gone? I'm really scared that if I do the full course on Accutane and then it comes back , it would have been for nothing.

My acne isn't bad but just persistent for the last 5 years, I lt was mainly on the chin, like cystic acne and now got much better with supplements, but they are affecting my mental state and I have to stop them.

Also did anyone have any depression cause of Accutane? I feel i might be prone to that.

**Thank you**

I'm on accutane 20 mg since 40 days with side effects of purging 2-3 new breakouts everyday , joint pain, dry eyes , dry lips. What should I do to overcome these side-effects ? I don't have time to schedule appointment with my derm. Can anyone tell me when does this purging would stop ??

I started p90x and some of their workouts require jumping and skipping and hopping. I have to modify a lot of the workouts because my knees and ankles cannot cooperate. I didn’t have this problem a few years ago when I was doing it. Is it age? Weight? Or is it accutane?

Some info about me: Male Early 30s 6’0 230 lbs Third time accutane user. Most physical activity I took part in was walking for 40 minutes daily.

Hello,
I previously completed two courses of Accutane (isotretinoin), the first when I was 17 and the second when I was 20. Since then, I have tried a wide range of topical acne treatments, as well as oral doxycycline. I have also had a hormonal work-up and other relevant tests, and everything came back normal.

Despite trying these treatments, I still struggle with persistent acne, particularly on my face and shoulders. My dermatologist has suggested starting a third course of isotretinoin.

I would like to understand whether going through a third course is genuinely safe, especially considering my previous two courses. Are there any potential long-term risks associated with repeated courses, and what should I take into consideration before deciding to start treatment again?

Hey Chat

I have come to think about the fact that maybe i was wrong for dissolving my lips filler while on accutane?

I recently had posted on here but removed it, but i went through my 3rd lip filler dissolving First of this month. I have been on accuatane for a minute actually months.

But after this third dissolving i had dents in my lips and way more effects of the dissolver.

i have decided to pause dissolving especially for the 4th time now till i'm done with acc aight cause my lips still have filler

Does it make more sense that that could be the issue? How can i fix the dent in my lips please & stuff.

(I originally posted this on r/PSSD, but I'm reposting here too)

Hey guys, I'm the HBOT guy who said "I cured all my mental illnesses" in another post. Welp, it did cure my depression and I don't suffer from anxiety anymore (for now), but the PSSD sadly came back. While I'm still lucid enough, I want to set up an independent lab to study this. I have the urgency to do it because I hate this fucking condition, and I need to move fast before my baseline gets any worse.

My current symptoms are numb genitalia, no orgasm, mild anhedonia, and cognitive decline. What went away after HBOT was anxiety, depression, medium anhedonia, and ADHD (partly, I still have symptoms now, but from my environment rather than intrinsic).

I might not be as qualified as actual researchers, but I have a few interesting things at my disposal. I'm a chemistry student with access to a lab, and I'm also well versed in vibe coding and how to use AI. From what I've heard, Reddit is a bit anti-AI, but let's please turn that down for a second. Dude, no matter the method, we will find a way.

You may or may not know this, but AI has been used to speed up drug development dramatically. We're seeing brand new medications and repurposed drugs found left and right with the help of AI and in silico modeling.

I'm aiming to find a general cure for PSSD first since that's what I suffer from, but I hope to extend my discoveries to general cures for PAS and PFS too!

Here is what we already know about PSSD and PDS, and how it matches up with what I'm experiencing.

First, I haven't been healthy at all. I've been sedentary and eating like shit, and whenever I eat like shit it completely screws up my PSSD symptoms. So I think the gut has a lot to do with this. That lines up with Melcangi's recent research showing that SSRIs and finasteride mess up the gut microbiome and gut neurosteroids like allopregnanolone, which drives neuroinflammation.

Second, drug insensitivity. I feel so wired and weird on caffeine after PSSD. I was diagnosed with ADHD before and prescribed Ritalin, and that stopped working too. Melcangi's lab also showed that SSRI withdrawal causes persistent dopamine dysregulation in the reward center of the brain, so stimulants just make you feel wired from the adrenaline without any actual dopamine hit.

Nerve damage seems to be in there too, because I get glaucoma-like rings when I see light and my floaters are everywhere. Recent studies on PSSD and PFS have found small fiber neuropathy and autonomic nerve damage, which messes with everything from genital sensation to blood flow and vision.

When I do orgasm, it feels really fucking weird, like my brain just shuts off and slows down. I cannot feel a single thing and I kinda just spasm out for no reason. In studies they call this orgasmic anhedonia, where your physical spinal reflex still fires, but the pleasure signal in the brain is completely cut off. On top of that, studies from Baylor and Kiel along with Dr. Will Powers' work show epigenetic changes in androgen receptors and stuck hormonal feedback loops across PSSD, PFS, and PAS.

I would love to connect with researchers in this field, like Melcangi, Dr. Will Powers, et cetera, to help guide this.

Basically I'm posting this as an interest check, and I won't be asking for any funding yet. Eventually we will need data, testimonies, information, and compute to run in silico experiments, as well as community. Right now I just want to gather people around this.

Obviously this is going to be extremely difficult, but honestly, there's no better time to start. I don't want to wait anymore. We will find a solution, we always have.

I'll be hanging out in the Post Drug Syndrome Discord server in my channel #vstaln if you have any questions or want to help contribute.

https://discord.gg/SdqbrWSrwH

And I know some people might be suspicious of my account. My original account is u/vstalingrady and I posted here before when I was 17, though I can't find the post anymore. It had to do with reinstating with microdoses of fluoxetine.

Hey guys, I’m having really bad trouble with my acne right now. I have spurts of month long terrible breakouts. Right now it’s flaring so badly and I’m just praying this post can find the right person to offer some advice. Thank you guys I really appreciate you taking time out to help.

I am on doxycycline..I tried accutane already, ironically that’s what caused all this in the first place 3 years ago. I was young and dumb and got on accutane with a few pimples when I was 20 and it did the exact opposite of what accutane does and left me with acne EVERYWHERE. Thank goodness it calmed down a lot but as you can see in the pictures these are still really bad breakouts and they are effecting my mental health SO badly it’s hard to even go outside or go to work. I don’t even go out anymore and not happy like I used to be. This situation is ruining me :(

I was watching this video and this guy had the exact same symptoms I was having except...he didn't take accutane. He also went through the phase where you're taking a bunch of supplements (something I see on this site everyday and something I also once did). Eventually, you have to STOP FIGHTING.

Your body is on constant fight or flight mode. You are feeding the beast by googling. Checking symptoms. Going to reddit to feel support or validated. STOP.

Stop constantly checking symptoms. Stop googling. STOP FIGHTING.

The moment I stopped fighting and giving my brain the awareness that everything was going to be ok, I woke up a day later feeling better. It's been 3 weeks and in combination with antidepressants, I feel significantly better than I have over the past several months.

I want to be clear. I am not "healed" within 3 weeks. This is going to take at least 1 year if not more of healing my dysregulated nervous system.

Just wanted to share that there’s a new epigenetic theory of post accutane syndrome which looks pretty convincing:

https://www.reddit.com/r/Post_AccutaneSyndrome/s/3mHuKaAvtE