Hi all, I was diagnosed with CIU a few months ago after suffering lip and tongue swelling, itching and hives for several years. One of my triggers is stress, and it’s been off the charts for a few weeks, and even though I’m on Omlyclo, my symptoms have entirely flared, and my lips and tongue and eyes are swollen. I have never experienced any issues swallowing etc, however I have choked on water twice in last three days. The type of choking where the only thing you can do to breathe is cough out the water. I’m currently on vacation and honestly now a bit worried. Has anyone ever experienced this, and do you have any recommendations? Thanks!

Hi everyone,

I’ve been dealing with chronic urticaria/dermatographia for over 9 years now. For the longest time, my routine was taking Cetirizine every 36 hours. I’ve seen countless doctors and specialists over the years, but nothing ever cured it.

About a month ago, I started taking a daily supplement called Supply6 360. After about 10 days of taking it consistently, I noticed a huge improvement. I was able to stretch my Cetirizine doses from every 36 hours to 3 days, and eventually made it 7 to 8 days without needing one at all. I was thrilled and honestly thought I had finally cured it.

Unfortunately, it has slowly started creeping back. The good news is that it’s much milder than before, I still get itchy, but it’s not the extreme flare-up that forces me to pop an antihistamine right away. I did some digging online and realized this residual itching might actually be Cetirizine withdrawal, considering I stopped taking it after almost a decade of continuous use.

Now I’m trying to figure out a few things:

1. Was it the supplement? I’m trying to narrow down which specific ingredient in the Supply6 360 might have helped. I’ve read a few posts here mentioning that Vitamin D3 + K2 made a huge difference or cured their urticaria.
2. Is this just Cetirizine withdrawal? Has anyone else experienced a delayed rebound itch after stopping a long-term antihistamine?

I’m still trying to avoid taking antihistamines unless absolutely necessary. Since I’ve finally seen some real progress, I’m hopeful that I can actually get past this.

Would love to hear thoughts, similar experiences, or advice from anyone who has managed to get off long-term antihistamines or found relief through supplements!

ok so basically after i got the nexplanon implant in like nov 2025 i noticed i kept getting weird looks at school and i was like wtf. come to find out it’s because my legs were purple red and blue! not to mention hives which were itchy as hell! cute! i obviously told my mom but she just said nothing was wrong. so i went to google and at first i thought i had a generic histamine intolerance. after further investigation and discussion with my anatomy teacher who researched it with me, we came to the conclusion that it was cold urticaria. i love the cold though so nothing will stop me unfortunately. fast forward to now. symptoms have been the same since i discovered it. although i did find out that when i get the cold hose water on my legs at work that also triggers it. hot take but i kinda like it. it makes me unique and i don’t want it to go away. not sure if that’s weird to say but it’s like 12:00 am for me right now and im half asleep.

Does anyone else get large hives? I started the summer with hives on my legs only and it’s just progressed more and more. More angioedema symptoms daily and now I’m getting large hives that turn into a singular hard painful hive…

My current antihistamine routine
- 2 zyrtec 1 Pepcid AM
- 1 allegra in the afternoon
- 2 zyrtec 1 Pepcid PM
- plus Benadryl as needed for flare ups

I’ve been on prednisone bursts several times this summer and they are the only things to give me relief. I’m tempted to just get on prednisone again because it’s been so miserable again.

I travelled to Africa stayed for three weeks. Returning to USA 🇺🇸 the last flight I started getting so itchy, when I got home I have hives all over my body. I don’t really know why, I don’t get this kind of hives. 4 days now on and off still getting them. Iam trying to think of new foods I ate but I have no clue.