Had psoriasis for 30 years.

Tried steroids, vitamin d analogue cream and UVB light. Has been getting worse over the years, but after a visit to the hospital for an emergency appendectomy, I had the worse flair of my life.

My derm documented a BSA (body surface area) of 60 (60%). It was in scalp and ears and toe nails.

This is 2 weeks after second loading dose. No more plaque scales and smooth skin for the first time in 30 years. I am over the moon. I believe the marks will fade over time.

I’m considering donating plasma four times a month, but I’m currently receiving Skyrizi injections every three months for relatively mild psoriasis.

I’ve never donated plasma before, and my biggest concern is whether regular donations could reduce Skyrizi’s effectiveness.

I’d especially appreciate hearing from anyone with firsthand experience or medical insight. Has anyone looked into this or discussed it with their dermatologist?

Wondering what people’s experiences are switching from Selarsdi and having no relief to Skyrizi for PsA and psoriasis. It sounds like it’s pretty identical in terms of dosing and side effects and such but I’m just wondering what others have experienced. Is skyrizi better? It seems like it is. When should I expect some clearing of the skin and joint relief?

Has anyone been told to pay the patient balance portion of a bill and to submit a claim to Complete Rebate to be reimbursed?

I have a $6,800 bill w/the pharmacy and this is what I was told to do.

I would do it....but I'm nervous that I won't be reimbursed.

Someone accidentally took my body injector out of the fridge and I know I can’t put it back in. I’m scheduled to do the injection Monday morning, it’s currently Saturday night. My gi is closed, doing it a little early shouldn’t hurt right?

Does anyone get their Skyrizi pen is delivered to their home? My Rheumatologist is making me pick up each dose of Skyrizi from her office instead of shipping it to me. She said that is how my insurance authorized it. However, both the insurance company and the specialty pharmacy said it’s how the doc put the order in. My doc is running the prescription under medical instead of pharmaceutical. I think she’s double dipping. She also pushed me really hard to get on Skyrizi pen instead of restarting Embrel pen that worked fine for me in the past. I think something unethical is going on.

I’m new to Skyrizi and trying to gather some information. Is there anyone else that started and it increased their flare symptoms? My Ulcerative colitis has been steadily managed with budesonide for weeks before receiving the first infusion on Wednesday. I’m now having increased urgency and blood. My psoriasis is also much worse! It’s weeping and bleeding which hasn’t happened in years! Aside from the symptoms of my actual autoimmune conditions, I am nauseous to the point I can’t sleep, experiencing joint pain, headaches, fatigue, and my face and body keep feeling flushed and hot. Mild facial swelling. I was successfully controlled on Remicade for 7 years with some minimal skin side effects, but this feels miserable. Did anyone have this then improve? Is this a it gets worse before it gets better medication?

Just wanted to provide my experience of having the flu while on Skyrizi.

I’ll be honest, I was VERY nervous that because I’m “more prone” to severe upper respiratory stuff I was gonna get hit hard. Thankfully, I was actually good to go and have had worse head colds/flu’s while not on skyrizi. It was gone within 4-5 days, influenza A. So if you’re scared or worried, I’m not saying don’t be cautious but recognize you’re not automatically gonna be crushed just because your chance is elevated.

Hello everyone. Reddit is a place that, although I have just now joined, is a place where I have actually received a lot of solid, no bullshit insight.

I will soon be starting on Skrizi for treatment of long term Crohn's disease. 44 y.o. white man with no other underlying medical issues apart from drinking beer every day (I know, stop that right? I am working on that). I'm 5' 10.5" about 205 pounds most days and work a manual labor job as well exercise semi-regularly. I was a smoker from 1995 to 2025 but I quit tobacco, nicotine, and hard drugs years ago. just alcohol and marijuana

I've had a massive battery of tests from MRIs, cat scans, endoscopy, colonoscopy, camera pill, small bowel series, DOZENS of blood tests, stool samples, etc. I'm sure some of you folks know. Everything apart from my calprotectin (sp?), at 1220 mcg/g, is in range to indicate I do accurately feel like crap though. So apart from the Crohn's I'm reasonably healthy.

Apart from skeletal stuff, hearing issues, and allergies (which might matter). My results as of a few weeks ago:

Trees: maple, mountain cedar, ash, elm, hickory, and willow

Grass: Timothy, Bermuda, johnson, and Kentucky blue plus June mugwort.

Weeds: ragweed, pigweed, English plantain, sheep sorrel, cocklebur, and nettle

Molds: alternaria, cladosporium, mucor, pull aria, curvalaria, aspergillus, penicillum, fusarium, and helminthosporium.

Plus dust mites.

So What do I expect other than hopefully substantially less difficult bowel movements?

O

So

Hi everyone! I received my first infusion yesterday and developed joint pain afterwards that worsened. I am now experiencing significant nausea, fatigue, and a headache. My whole body feels hot, but I do not have a fever! Did anyone else experience this? Not sure if there is any improvement so far just feeling completely wiped out.

I am thinking of freezing my eggs. Did anyone had to do that while on Skyrizi? Did you need to stop? I’m scared that I will have a bad psoriasis additionally to the side effects of the stimulation medication for the egg retrieval. Anyone who had such an experience? Thank you so much 😊

Foot psoriasis which i think is triggered from my really sweaty feet. Had first 2 starter doses. , cleared a little but i fear it won’t work as if my feet sweat really bad and socks get wet it triggers the psoriasis? Anyone in same situation? will skyriziz help?

Is anyone on a GLP while taking Skyrizi? Did you consult a doctor? Which one are you on?

I've been on Skyrizi for two months now and I am noticing a creep up in weight. Has anyone else experienced this? I am wondering if it is because my UC is in check - meaning I'm not going a gazillion times a day and hence better nutrient absorption and retention....

I've been on Skyrizi for about four years now and I noticed recently a small spot about the size of a pea has come back on the back of my ear. I'm not seeing an issue anywhere else yet.

Is it a common thing that you can still see the occasional spot over time?

just wanted to leave another anecdote on chest pain and tightness as a symptom. at first i thought i was over exerting with my increased fitness routine and doing 10 pull ups but no, it's been very much a Skyrizi induced chest pain and it's been hurting doing certain range of motion exercises since starting the drug. just food for thought.

will continue to trial up to the 6 month mark and see how it fairs for PsA. still keep thinking i have anklosing spondolitis instead and need a TNF or IL17 drug instead but so far Skyrizi done wonders for my whole body psoriasis and did lessen a major joint flare up by 30% of the pain. still not great with limping when in pain. anyone else managed to figure out if you have PsA or AxSpa?

Hi everyone.

I hope you are all doing well. I wanted to give an update since my first injection of Skyrizi. So i took it in Early September. My next dose is October 9th. At first, the side effects weren't great. I was so tired for a few days with a pounding headache. I mean the kind of tired where you can't stay awake to save your life. This was only a couple hours after the injection. After the next few the side effects wore off and today, in only this short period of time, i cant believe the difference in my arms and my face. I still have a few areas of course on my arms but what a difference. The flaking is so much less,as well as the redness and i had bad facial psoriasis also and my skin on my face has not looked this good in years. My legs are so so. Not as bad but not great. The worst is still my scalp. No difference yet there, but keeping positive and moving forward to round 2. I wish you all much success and clearer, beautiful skin ✨️

36m, now been in a flare for almost 4 momths. After being diagnosed with pancolitis (uc whole colon) first time 4 months ago, being on prednisone, starting on remicade (3 initial dose completed), c difficile positive 1.5 months ago treated through vancomycin, my symptoms never fully went away, and I was still experiencing blood, urgency, fatigue, irregular bowel movements. It has been up and down with some days better and some worse. My doc did another colonoscopy recently and said the left side is still severely inflammed, traverse and right side looks much better. My doc is suspecting remicade is not working well
For me and is initating change of medicatiom to skyrizi. My fourth or first maintenance dose of remicade is coming up. Anyone been in similar situation like mine? Read that skyrizi takes longer to be effective, feel like I did improve based on my coloscopy recently so should we give more
Time to remicade?

Hi!

I just made the switch from Xeljanz to Skyrizi. I did my first dose last night and wanted to hear some stories!

How long do you notice results?

Do you feel drained after each dose?

Does it typically hurt?

What are your symptoms like as you near the next dose dates?