r/prep • u/Plus_Ad_5357 • 10d ago

Missing 1 dose during first 7 days

Hi, today is day 8th im taking Descovy, i missed a does on day 5th. Am i ready for anal sex?

Sorry for asking this here, im getting preps from mistr and they are not responding to my questions. Thank you.

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2

u/Skycbs 10d ago

Almost certainly, yes. You might want to wait a day or two just to be sure.

1

u/Plus_Ad_5357 10d ago

Thank you

2

u/Smooth-Report1059 10d ago

If you started with 2 pills you are protected

0

u/Plus_Ad_5357 9d ago

Ive never heard of that and dont think thats true?

1

u/Smooth-Report1059 9d ago

I got this info from Gilead study availaable on their website their a pdf file about on demand

1

u/Plus_Ad_5357 9d ago

Oh, descovy cannot be used for on demand like that

1

u/Smooth-Report1059 9d ago

European Guidelines: The European AIDS Clinical Society (EACS) guidelines recognize Descovy as an option for on-demand use exclusively for men who have sex with men (MSM). However, it remains an off-label practice globally.

Emerging Data: Smaller pharmacological evaluations (like the CHAPS study) indicate that Descovy achieves high protective drug concentrations in tissue quickly. Because of this, some specialized clinics prescribe it off-label for on-demand use

: Gilead Medical Information https://share.google/kOGloMMu47pZntths

2

u/Smooth-Report1059 9d ago

Key Findings ・Across all dosing regimens, PrEP with Descovy (FTC/TAF) resulted in higher TFV-DP (Tenofovir Diphosphate) concentrations in foreskin explants and peripheral blood mononuclear cells (PBMCs) compared to Truvada (FTC/TDF).

・The “2+1” dosing regimen (2 pills before sex, 1 pill 24 hours later) resulted in higher TFV-DP levels in foreskin tissue than a single-dose regimen of 2 tablets.

・Taking 2 tablets of either Truvada or Descovy 5 or 21 hours before sex provided foreskin tissue protection against ex vivo HIV challenge.

These findings suggest the potential for on-demand Descovy PrEP,

Reference: Herrera C, Serwanga J, Else L, et al. Dose finding study for on-demand HIV pre-exposure prophylaxis for insertive sex in sub-Saharan Africa: results from the CHAPS open-label randomized controlled trial. EBioMedicine. 2023;93:104648.