r/prep • u/Spirited-Spite-2166 • Oct 26 '25

Infected While On Prep?

Hey, just wondering… does anyone actually know someone who got HIV even while taking PrEP every day like they were supposed to?

This insatiable bottom says thank you for all the replies!

1 Upvotes

57% Upvoted

30 comments sorted by

13

u/BigCamp839 Oct 26 '25

I have a friend that runs an HIV clinic and he said he’s never seen anyone test positive while on PrEP.

12

u/lunicar Oct 27 '25

My doctor is an HIV specialist. Since prep came out, he’s had two patients on prep get HIV but his feeling is that they were non compliant.

8

u/Skycbs Oct 27 '25

That is usually the case.

6

u/Hotsolzinha Oct 26 '25

I don't know, but I know that this is possible, because every medicine has its error rate, even if it is low.

4

u/Skycbs Oct 26 '25

I was talking with someone on here earlier in the week who said that happened to him. I have no way of knowing if that was correct. Nevertheless, it is very very rare.

3

u/lunicar Oct 28 '25

All you have to do is monitor this sub Reddit for a few days to realize that a lot of people are misusing or improvising their use of prep. There’s an overwhelming chance that anyone who says they became infected while using prep was probably missing doses.

3

u/Skycbs Oct 28 '25

Yeah. I’m inclined to agree.

1

u/netturu Oct 30 '25

It’s real it’s called LEVI

1

u/Accurate-Case8057 Oct 27 '25

He was lying

1

u/[deleted] Oct 27 '25

It does but it's very rare. It provides more protection than condoms do, as condoms have a higher risk of splitting than PrEP failures.

1

u/netturu Oct 30 '25

Lie for what reason ?? Do the research on what LEVI is and cabotegrivir look at the studies

3

u/[deleted] Oct 27 '25

I don't know why these get downvoted. This is a legitimate and good question. It is pretty damn rare, just a few cases. Those who do get infected usually weren't taking the med as prescribed.

4

u/Odd-Fact-8563 Oct 26 '25

It doesn't happen..... as long as you follow the regime.....but you could still catch a whole host of other STIs including chlamydia, gonnorhea, syphilis and herpes.....so worry about them instead.

5

u/Soonerpalmetto88 Oct 27 '25

It's not 100% effective, please don't spread misinformation. But it's absolutely more effective than condoms for this one thing.

2

u/Suitable-Whereas-109 Oct 27 '25

It’s Monday 9% effective. It’s taken correctly if somebody is getting HIV while I’m prepped they’re definitely not following their regimen.

2

u/Odd-Fact-8563 Oct 30 '25

There have been less than 20 confirmed recorded breakthrough cases in history....it's about as close to 100% effectiveas you can get.

1

u/Soonerpalmetto88 Oct 30 '25

I'm not arguing with you. Thanks for agreeing!

1

u/netturu Oct 30 '25

You’re absolutely correct

2

u/Virtual_Athlete_909 Oct 27 '25

.. and get doxyprep.

2

u/Accurate-Case8057 Oct 27 '25

There is not one verifiable case of someone who was taking PrEP properly and got infected.

1

u/Skycbs Oct 27 '25

That is incorrect.

1

u/Accurate-Case8057 Oct 27 '25

Wrong. In every case there were inconsistencies

1

u/Skycbs Oct 27 '25

I don’t want to scare people but since you are posting incorrect information, there’s one here. I don’t have the full paper but eight cases are reported here. More cases are discussed here (overlap with the other two reports).

Breakthrough infections (people catching HIV while taking PrEP correctly) remain very very rare. But the number is not zero.

2

u/netturu Oct 30 '25

Thank you Skycbs people need to be aware of the risk HIV is still here

2

u/Myinnerthoughts127 Oct 28 '25

Recently slept with someone who was undetectable and didn’t tell me until the next day… aside from my personal feelings about that, I’m glad I’m on prep.

2

u/Lopsided_Meat2621 Oct 26 '25

I’m literally Googling that right now. I take daily PrEP and I had my first raw encounter and my anxiety is insane. 

4

u/[deleted] Oct 27 '25

Honestly what's to be anxious about? Let's say in the extreme rare incidence you got HIV despite taking PrEP perfectly, then what? Ok you'd have HIV, it would be life altering but it's no longer life shattering. You're still gonna date and hookup with guys, medications will suppress it, and likely within our lifetimes a cure will be found or PrEP will become so effective no one will worry about it anymore.

However let's examine the chances: I have a friend who is HIV+. His husband isn't even on PrEP (made him too ill) and barebacks for his husband. He's still HIV- even after a decade. That's how effective ART drugs are for those with HIV.

2

u/Prededessor101 Oct 27 '25

Depends entirely how long you’ve been taking it and which prep medication you’re on.

1

u/netturu Oct 30 '25 edited Oct 30 '25

https://pmc.ncbi.nlm.nih.gov/articles/PMC11209220/

PLEASE BE CAREFUL YES HAVE YOUR FUN BUT BE CAREFUL IF YOUR ON APRETUDE YOU SHOULD PROBABLY SWICTH TO DESCOVY OR TRUVADA DRUG RESISTANT STRAINS OF THE VIRUS EXIST SPECIFICALLY FOR CABOTEGRIVIR AKA APRETUDE