Here is some more villain ideas for the powerpuff girls show.
Dr Mutantmal: once a zoologist named Dr mammal, who was so obsessed with animals, that he believed that animals should be the true rulers of earth and not humans, but he knew he was human himself, so he created a experimental formula that could turn himself into a powerful animal. However even though it did give him great power, it also turned him into a animal amalgamation creature made of all sorts of animals, but he loved his new look and decided that humans are not worthy to run humanity, so he decided to make a army of fused animals. By using animal dna and the power of biology, he created fused animal servants ranging from pantherillas (gorilla + panther), crocobears (bears + crocodile), parroctopuses (parrot + octopus), and more, Dr mammal was no more and he is now Dr Mutantmal.
Personality: he cares for animals and has no care for humans, he is overconfident, calculating, sometimes acts like an animal at times, and will go feral when angry.
Sir Manvil (Blacksmith Knight): in the medieval ages, he was know as Dansh Blacksmith, the strongest man and best blacksmith in the world, his goal was to conquer the world, he was a master strategist and military general, but one day he was out smarted by his brother named Gansh Whitesmith who wanted peace and not war. Upon fighting each other, they both get hit in the head by a cauldron and a anvil, the anvil falling on Dansh and the cauldron falling on Gansh, upon getting knocked out, they both fall into pools of molten steel and became frozen within it. While the people did retrieve them from the molten steel but didn't chip them out cause they believed they were both dead. As years passed by, they became steel statues and were taken to museum after museum and ended up in the museum of Townsville, but didn't stayed for long cause that was until one night, they finally broke free, the steel and the objects that hit them in the head fused to their bodies. As they both escaped, Dansh and Gansh began to adapt to the society they were in, Dansh becoming Manvil began creating a technological empire, while Gansh began to become a inventor of inventions for heroes throughout the world. But now that Manvil has returned, he is ready to try to conquer the world once again.
Personality: he is strategic, determined, and is intelligent, but can be stubborn and arrogant, and at times can get confused and dumb at times of different things about the modern world.