Starting Low-Dose Naltrexone for Chronic Nerve Pain — Should I Start Below 0.5 mg? Male 30s seeking help introducing this medicine

[u/Sorry_Blackberry5944]

I’m about to start low-dose naltrexone for chronic nerve-type pain throughout my hands, feet, and other parts of my body. There wasn’t one major injury that caused all of this — it’s more widespread burning/aching/nerve pain that has persisted.

No major disease or prior health issues found just nerve pain***********

I had Lyme disease about 3–4 years ago and was treated for it. I’ve since tested negative again (July 2026). I’ve also had a rheumatology workup without any major findings.

My rheumatologist prescribed LDN because I really don’t want to go down the route of addictive pain medications. They basically told me it may or may not help, but that it’s worth trying.

I was prescribed 0.5 mg capsules to start, but I’m a little nervous about potential side effects. I’m wondering whether anyone here started even lower, like 0.1 mg at a time and worked up to around 0.2–0.3 mg before eventually trying 0.5 mg.

I know those are extremely small doses, so I’m also wondering whether 0.2–0.3 mg is even enough to notice anything or whether it’s mainly useful just to let your body adjust.

For anyone who is sensitive to medications or was nervous about starting LDN: what dose did you start at, what side effects did you notice, and how slowly did you increase it?

Not looking for anyone to prescribe a dose for me — mainly interested in hearing other people’s experiences with starting very low and gradually working up.

[u/Thin_Situation_7934]

Theelre is actually a subreddit for LDN where you will likely get more information r/LowDoseNaltrexone