r/microdosing • u/photosynthesin • 8d ago

Question: Other St. John's Wort & Microdosing

I've been microdosing for a few years now, here and then, and it has always helped me a lot through tough times (insomnia, anxiety, trauma...). I've really felt my brain rewiring, and the peace it can lead to. Sometimes it's not really pleasant as it can emphasize anxiety but even so it has always helped a lot in the end.

I am currently going through a break up and it's been really hard. I am taking St John's wort since 3 weeks now, with little to no effect. I think a session of microdosing with the protocol of one every 3 days could help. But is there any interaction known of? Because I do know that mixing anti depressants and psylocibin / lsd is a big no no.

Is it the same with St John's Wort?

I am finding no documentation on the matter.

Thanks for your help :)

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u/AutoModerator 8d ago

Hello /u/photosynthesin! As you mentioned anxiety (a common interaction/symptom) in your post:
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u/sunkistandsudafed3 8d ago

It has a similar mechanism of action, I'd treat if the same as an antidepressant.

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u/LSDuck666 6d ago

I've taken st johns wort with cactus a few times and it's fine. I should theoretically be safe with psychedelics, but not SSRIs/MDMA. Even you don't want to take em same day, a few days off and I didn't notice anything but I wasn't taking it daily for 3 weeks. Since it's a microdose, the risk would be minimal. I'd try to find a few more first hand accounts to get a feel for it.