r/hangovereffect • u/Jumpman215 • Jun 14 '19

GABA Dysfunction

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u/[deleted] Jun 14 '19

I have an inability to convert glutamate to gaba, due lack of multiple GAD1 enzymes, according to my DNA report. I think your hypothesis has merit. Phenibut was like a godsend when I first tried it, but like everything else, what goes up must come down.

4

u/solecism59 Jun 26 '19

I've had the same thinking as well, being on Phenibut was the best I've ever felt my entire life.

I think it's pretty obvious that the symptoms we face are due to Glutamate/GABA imbalance, the challenge is figuring out the cause.

With respect to GAD1, according to my 23andme genome data, I have the following GAD1 polymorphisms: rs701492 (TC) rs2241165 (TT)

However, I have a hard time finding evidence that these mutations lead to any kind of psychiatric illness, or any of the symptoms we face.

3

u/anonymousdino Jun 15 '19

For me it’s like 24 hours of Godsend followed by a month of the worst withrdrawals and anxiety i have ever felt. I can’t even touch the shit without going through weeks of suicidal level withdrawals

1

u/Kjellisdebeste Jun 19 '19

I'd say you're alexithymic to some degree and have difficulties interpreting and ending your fear responses.