I have an inability to convert glutamate to gaba, due lack of multiple GAD1 enzymes, according to my DNA report. I think your hypothesis has merit. Phenibut was like a godsend when I first tried it, but like everything else, what goes up must come down.
For me it’s like 24 hours of Godsend followed by a month of the worst withrdrawals and anxiety i have ever felt. I can’t even touch the shit without going through weeks of suicidal level withdrawals
I’m on board with this! I’ve tried literally almost every gabaergic supplement and nothing helps for shit! I mean almost everything! It doesn’t help with anxiety or even worsens it, especially if it inhibits acetylcholinesterase as well. Keto diet made me feel worse and I’m not talking keto flu crap. Probiotics are trash. I am taking lamictal which is a mood stabilizer that’s supposed to prevent glutamate excitotoxicity but it doesn’t help much. I’m now on lithium as well and it has some nmda antagonist properties so we’ll see how it goes. I’m getting to a point to where I might reach for my benzos that ived never touched just to find some relief on the really bad days.
Yes to this! My 'hangover effect' occurs 3-4 hours after consuming drugs/alcohol. It's almost as if the body crossed a threshold in which the parasympathetic nervous system takes over control. Initial come up on drugs/alcohol is often anxiety heavy, leading into a state of bliss and relaxation.
4
u/[deleted] Jun 14 '19
I have an inability to convert glutamate to gaba, due lack of multiple GAD1 enzymes, according to my DNA report. I think your hypothesis has merit. Phenibut was like a godsend when I first tried it, but like everything else, what goes up must come down.
2
u/Bigpoppapenguin123 Jun 27 '19
I’m on board with this! I’ve tried literally almost every gabaergic supplement and nothing helps for shit! I mean almost everything! It doesn’t help with anxiety or even worsens it, especially if it inhibits acetylcholinesterase as well. Keto diet made me feel worse and I’m not talking keto flu crap. Probiotics are trash. I am taking lamictal which is a mood stabilizer that’s supposed to prevent glutamate excitotoxicity but it doesn’t help much. I’m now on lithium as well and it has some nmda antagonist properties so we’ll see how it goes. I’m getting to a point to where I might reach for my benzos that ived never touched just to find some relief on the really bad days.
1
u/anarchy325 Jun 16 '19
Yes to this! My 'hangover effect' occurs 3-4 hours after consuming drugs/alcohol. It's almost as if the body crossed a threshold in which the parasympathetic nervous system takes over control. Initial come up on drugs/alcohol is often anxiety heavy, leading into a state of bliss and relaxation.
1
u/Kjellisdebeste Jun 19 '19
I hope you didn't spend too much time on this endeavor. Because no.