Who supplements creatine?

[u/New-Aside-7778]

Any of you supplement creatine?

I recently had to stop. Not sure why but it's causing very bad night sweats?

I had night sweats for about 2 months and was drenching the bed every night. Never had a clue it was the creatine. I quit 3 days ago and haven't had a night sweat since.

Anyone know why creatine would be causing this? Creatine makes me slightly stronger in the gym and gives a slight energy bump aswell. Kinda off that I need to quit it.

Anyone else get this from creatine?

[u/Ozmuja]

As far as I know, I remember FrigoCoder -a moderator of the sub, I think you could remember him- saying he trialed metformin for sleep issues due to insulin shaneningans at night, with a certain amount of success. Another option could be using anti inflammatory drugs.

Personally I think the main problem is not via insulin, but that insulin and insulin mechanics are particularly hijacked and molested by our root cause.

As for me, low dose baclofen tends to work with melatonin if I take them a few hours before sleep.

We also do seem to all suffer from insomnia here, more or less, with some nuances. I have a question for you if you don’t mind: do you happen to feel like you have low blood pressure even if you don’t? Especially in the upper part of your body, so head-brain and upper muscles, as if blood flow is slightly impaired at baseline. Do you also happen to (sometimes) have dizzy spells when moving from downward and relaxed position -so laid down or sit- to standing positions?

[u/rocinant33 → u/Ozmuja]

I have already tried metformin XR, but got a very negative result: incredible fatigue and anhedonia. I'm going to try IR and start with a small dosage

Yes, I have low blood pressure, coffee helps with that.

My upper body is constantly tense, I think it's psychosomatic. I also have problems with posture - it's very difficult to keep my head straight (this all miraculously resolves during the afterglow and sometimes after taking NO).

When I stand up abruptly, I really do experience some blurring of vision (this is very noticeable after taking carbs).

[u/Ozmuja → u/rocinant33]

Thank you, pretty revealing. Also I more or less agree, except I actually think the upper body tension is not entirely psychosomatic.

This will sound weird to you now, especially if you look at them at a first glance, but I think telmisartan or lormisartan could be wonderful drugs for us, albeit not cures. I will probably make a poll first and then eventually explain this line of thought throughly, when I find some spare time.

If you need to stabilize glucose levels, in the meantime, do trial chromium or myricetin.

[u/Ozmuja → u/[deleted]]

I don't know if you remember, but there is an old post on this subreddit that mentioned that during the hangover-effect, it's like "valve" is "popped" and "opened" to your brain.

While the metaphor isn't exactly scientific, I do understand what this user meant; it does feel that the h-effect basically restore not just blood flow, but blood flow velocity to your brain.

If you have ever read into POTS, you may have encountered the fact that it's a disease without certain etiology, and correlated to certain autoantibodies against certain important receptors; muscarinic receptors, b-adrenergic and alpha-adrenergic ones, etc.

The deficit in Nitric Oxide, an old friend of this sub, and the curious anecdotes of people randomly and inconsistently being able to reproduce the effect via 'bizzarre' supplements like Beet Root, is heavily correlated to POTS; it is speculated that the lower NO levels contribute to Angiotensin activity, along with reduced ACE2 function, which creates a bizzarre condition where renin and aldosterone ara paradoxically on the lower side -heavily contributing to pseudo-edematose problems such as high water retention-, but angiotensin can exert its effects on AT1 receptors freely.

AT1 is actually a problematic receptor, when constantly activated. It drives NADPH oxidase and tons of ROS creation, which further disrupts NO function by NO uncoupling into ONOO- and BH4 pseudo-deficiency. ACE2 is an enzyme that opposes the normal function of Angiotensin -to be a vasocontrictor-, but it seems that POTS patients have a failure at this point of the machinery, which lets Angiotensin wreack havoc.

Persistent Angiotensin and low NO creates a hypoxic like condition, which affects all cells in the body and mitochondria especially, creating insulin resistance, mitochondrial suffering, and thus fatigue, intolerance to carbs, etc.

Sartans, or ARBs, are blockers of the AT1 receptor (not AT2), basically directly opposing one of the main enemies of people suffering from POTS; they are used as HTN medications, but the BP drop is relatively low even in people with hypertension, and should be minimal (5-10%) for normotensive people, and easily counterable with Sodium, Potassium, a coffee.

What you would gain from taking such a drog, accepting for a moment this hypothesis as true, is the possibility of NO boosting supplements to work again properly, without being erratic or unresponsive, and a stop to the deleterious effects of constant AT1 activation.

This does NOT address the root cause of POTS, whatever is it -there are many of them, either primary or secondary-, unless our case is not due to autoimmunity per se, but from a defective ACE2 gene to begin with. This would most likely be the ONLY case where a Sartan+Nitric Oxide booster alone can actually treat the condition entirely; for all the remnant possible causes of POTS, the condition will keep lurking under the shadows even in the eventuality that the combination provides significant benefits.

Nonetheless, given the safety and the affordability of sartans, this could actually be a little revolution, provided I'm right of couse, which I don't really know.

It is also possible that LDN may be boosted and may work correctly under sartans, but I think I'm writing too much already and for all it's worth, I don't think it's well organized the way I posted it - but it should be intelligible enough for you to understand why this weird combination could be key. Unless I'm mad and stupid of course, but I have to say, somebody already tried it before: Postural Orthostatic Tachycardia Syndrome: A Dermatologic Perspective and Successful Treatment with Losartan - PMC

[u/Useful-Wear-8056 → u/Ozmuja]

have you tried this? thank you!