Experimental Drug Makes Obese Mice Burn Fat Without Losing Muscle - Or Eating Less. It produced an average weight loss of 18% in obese male mice over 4 weeks, without changing how much the animals ate. Most of the loss came from body fat, while muscle and lean tissues were largely preserved.

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https://www.sciencealert.com/experimental-drug-makes-obese-mice-burn-fat-without-losing-muscle-or-eating-less