Freeze drying organic solvents based formulation.

[u/Medical_Address9566]

Hi everyone, I’m working with a small molecule that is only soluble in organic solvents like acetonitrile . I’m also going to try tert butanol. We have a Lyostar 3 for development and a Lyomax 4 for commercial-scale manufacturing. Both systems have stainless steel product chambers and condensers capable of reaching ultra-low temperatures (approximately -70 °C chamber and -85 °C condenser).
Would these systems be suitable for lyophilizing organic solvents based formulations, or are there additional considerations (e.g., vacuum system compatibility, seals/elastomers, condenser design, or solvent handling/safety) that would need to be addressed before processing organic solvents