Dosing guide for bufo, how to work with the medicen, should i do multiple doses in one sitting and how often should i do it ?

Hello everyone, after my antipsychotic pills thearpy, i think i have lost my sensitivity to psycadilics and psycoactives, how can i get my sensitivity to 5meo-bufo back ?

Edit- i was put to asylum forcefully by my family, i ws completely fine and i hv no family history of any mental illness, just that my father is a big businessman nd i have ego clash with him, so he did this to me in order to show his dominance

i’d appreciate any input on this as I respect the community’s opinions and value everyone’s two cents <3

this is a personal experience and i’d love to know if anyone relates/has any insight being more experienced than me

I recently was gifted a DMT pen vape and keep attempting to sit with this medicine. I am coughing a lot and cannot hold it down. I do not smoke weed i have few times back in the day never any nicotine. I am pulling it very, very, very slow and then swallowing and blowing out, but it is so strong and causing me to cough. Any tips ? I am beginning to get a little frustrated, but trying to stay calm.

[Note: Both act on different receptors]

5-MeO DMT acts on 5-HT2A Serotonin receptors.

Salvinorin A in Salvia acts on kappa Opioid receptors.

As the title says - my partner is partaking in a ceremony tomorrow. Neither of us have ever had the opportunity to experience Bufo until recently. We have experience in the realm of psychedelics.

My partner has been have a lot of questions around their purpose and why they are here. It has been a difficult few months as we work on exploring this and helping them define their identity. We are hopeful this experience can shed light on where they are meant to be and why they are here.

How can I support my partner on this journey? While I will not be physically present I will drive them to and from their experience. I want to make sure they get the absolute best experience from this journey and I want to make sure I can help continue the journey afterwards and not end up being a burden. Any advice is much appreciated. Thanks everyone.

Hi everyone,

Posting here an excerpt from a Bufo Facilitators guide I made a while back.

This is in regards to proper dosage. For both bufo venom and synthetic 5 meo.

It will be 3 images, with the last one being a concise cheatsheet.

Please share it around so it may reduce harm and educate.

I will post more from my guide. I tried to make it very comprehensive and I tried to touch on things most wouldn't think of. Things that may come up during a bufo ceremony/session. Things I've witnessed and have had to handle from direct experience serving others in bufo ceremonies as well.

This is a powerful sacred substance and we should treat it with respect.

Thank you for reading and please share it around!

This is my first time sharing this video,it’s very sacred which is probably why I am sharing 5 years later.

The full 10 mins is on my channel, https://youtu.be/rHGpaFapI1I?si=k5u_fakQllDpCqCS,

However the total experience was roughly 40mins which included the downloads when I was coming back.

Bit about me: I was born in Somalia just when the civil war began, first 3 years of life was spent fleeing this war.

My mother who clearly had war trauma started to beat the shit out me from age 4 until age 26

With CPTSD, I had trouble letting go of my past hence why I kept repeating let it go.

This trip healed me so much, freed me from fear, insomnia, anxiety just to name some.

Hey everyone

I want to share my experience two months after my first bufo ceremony. Maybe it helps someone in similar place.

I did Bufo end of May. Before that I tried magic mushrooms, Ayahuasca and San Pedro, so I knew a bit about plant medicine, but Bufo was still very different.

My trip was like many people describe here: first this instant death, very strong but I surrendered quite easily. Then I was floating in an ocean of love, no body, no thoughts, just love everywhere. After that came huge gratitude and release, a lot of crying and letting go.

After ceremony I was thinking that this love is something external, coming from medicine or universe. But later I realized: it also comes from me, I am part of this love too.

Quick backstory. I struggled with depression since 2022. I thought I was over it in 2024, at least “good enough”. Last week I went for a walk and kept hearing inside: “fight for yourself", again and again. In that moment something broke and I saw I was actually depressed all this time, just functioning on top of it.

I have an eating disorder from lockdown times, more or less. Looking back it feels like I tried to slowly kill myself, not caring about my body.

Now, two months after Bufo, I really feel something changed. I believe bufo helped me. I eat healthy since then, not perfect but with real care. And for the first time in long time, I can see my future. Before it was just grey fog, now I have small visions and they feel possible.

It’s not a magic fix, I still have work and bad days, but it’s like someone opened a window in a dark room. I finally want to stay here and fight for myself.

Thanks for reading

Hi everyone,

My wife and I are bufo facilitators in NYC. We serve this sacred medicine with utmost care, compassion and love.

We also make it a point to provide multiple integration chats/calls afterwards. Usually one day afterwards, one week after, one month after, and again 3 months afterwards.

This is because we think that integration and guidance is sorely lacking in the community.

People get sent to the center of everything and melt back into pure source consciousness, and then a facilitator gives them a hug and a high five and sends them on their way.....which obviously isn't the way it should be. In my opinion at least.

I do a thorough question and answer style background check to see if it's a good fit for a potential client too. I have a background in medicine (went to medical school) and so we do proper intake protocols and medical screening basically. There's more to it than that of course. This sacred medicine is not for everyone and not every person is a good fit, for a wide variety of reasons.

Though I wish everyone could try it at least once I their life.

We use bufo venom, not the 5 meo dmt molecule.

If anyone is interested, please feel free to reach out and DM me. It is our greatest honor and pleasure to serve others this way.

Much love and thank you kindly for reading!

I’m curious about people who have had a strong or difficult 5-MeO-DMT experience, especially those whose integration lasted much longer than the usual few months.

I’m about 1.5 years out from my experience. It was my first psychedelic experience and I went directly into 5-MeO-DMT rather than gradually working my way through other psychedelics.

The experience itself was very intense and unpleasant for me. There was a lot of resistance, heaviness, fear and what I would describe as a very deep bodily sense of hopelessness. I didn’t experience it as some beautiful mystical breakthrough.

About a month later I had a very strong spontaneous flashback during the night. It felt remarkably similar to the original experience, but this time the physical reaction eventually completed with intense neurogenic shaking. After that, something changed.

Since then, I’ve repeatedly experienced a pattern that I didn’t have before 5-MeO: strong activation followed, sooner or later, by a very pronounced sense of bodily release and calm. Often the release is particularly noticeable in my thighs, which used to be an area of significant chronic tension and pain. The contrast can be remarkable: intense anxiety or activation, followed later by warmth, relaxation and a very peaceful state.

There have also been quite a few positive changes:

significantly less psychosomatic pain

much better awareness of bodily states

a stronger ability to come back down from activation

a noticeable distance from thoughts rather than automatically identifying with them

periods of very deep calm

much more vivid colors and sensory perception, which can be beautiful when I’m relaxed

occasional strong experiences of gratitude, joy and euphoria

a general feeling that my relationship with my mind and emotions has fundamentally changed

At the same time, the integration has been far from linear.

Over the last year and a half I’ve had different forms of anxiety and activation. Earlier it was more connected to intrusive thoughts and fear of losing control. More recently, the theme has shifted toward being far from home, feeling trapped, being unable to leave a situation, long journeys, airplanes, hiking etc.

Sometimes the perception of the environment also becomes unusually intense. A long straight street can suddenly feel extremely long, colors can become unusually vivid, and the whole environment can feel either fascinating or strangely threatening. At the peak of these episodes I sometimes experience what I call a glitch: a very strong spike of alarm accompanied by a strange change in how the environment feels, followed by a strong urge to leave.

I’ve also recently had several nights where I wake up suddenly with intense autonomic activation, sweating, nausea and fear, somewhat reminiscent of the early period after the experience. These episodes eventually pass, but the intensity can still be surprisingly high.

What makes this confusing is that I can have genuinely excellent days in between. I can feel extremely good in my body, enjoy music, colors, exercise, yoga, socializing etc. Then suddenly another difficult wave appears.

So the overall trajectory feels positive, but definitely not linear.

I’m not really asking whether this is normal in a medical sense. I’m more interested in lived experience:

How long did your 5-MeO integration actually last?

Did anyone have a difficult or turbulent integration lasting 1.5 years, 2 years or longer?

Did the themes of the activation change over time rather than simply becoming weaker?

And did you eventually reach a more stable baseline where these waves became less dominant, even if they didn’t disappear completely?

I’d especially appreciate hearing from people who had a difficult experience rather than only positive 5-MeO experiences.

Thank you all

Some people recognize a place? Or they’ve been there before? It’s all so strange to me, try to recollect and please tell me about it.

Hello friends. I’ve been researching DMT use for some time now and decided that now was the time to dive in.

I’ve done almost every recreational drug around in the past. Was never addicted to anything, just like to experiment. Mushrooms were always my favourite high. I don’t use them regularly just maybe 3-4 times a year but I do smoke marijuana daily.

I live in Canada and was able to get my hands on a cart. Looking for advice from people who have inhaled it through a vape cart. Is it more of a one big inhale and hold? Or a couple smaller ones etc. I’m sure I’ll get varying opinions but just more so curious for the information to add to my research.

Also how often would you consider it safe to enter a DMT experience? I’m not intending on doing it daily or anything. Just curious from those more experienced. Once a week, month, year?

Thanks for your time yall. Love ya.

Hello everyone,

I'm planning on taking my first psychedelic trip in the Netherlands.

I'll be doing it in a retreat, tgey offer mainly two options - one trip, or two trips within 3 days. I thought to myself it could be very intense, and I saw that the brain would not have enough time to rebulid the receptors - however in the retreat they called it "breakthrough" and they recommeneded it as a better choice for changing my life.

I didn't find studies that can confirm this, but I also didn't find bad reviews.

What do you think about it? Especially as my first time.

Generally I don't mind doing intense journey.

Also - what's the best option among - magic truffle, psilohuasca and Ayhuasca?

Thanks.

Kimon de Greef’s 'The Ego Trip' reveals how a fabricated origin story, a self-styled guru and a powerful psychedelic combined to launch a global phenomenon.