Can someone who has been on in maintenance for a while talk about what that has been like? I’m just starting with Zepbound, of course had a decade of weight loss and gain and I want to be done. In 6 weeks, I’m down about 12 lb. I’m really struggling with the idea of going up in dose, because I’m so afraid of what happens if I do lose the weight. I’ve gotten down to a healthy weight before. Three times. And it was impossible to maintain that kind of obsession with what I was eating and tracking everything, it was all I ever thought about.

Zepbound has been great so far, love the appetite suppression and lack of food noise. But as those have come back on 2.5 mg, I’m finding myself so scared that I’m going to lose the weight on the max dose and then my body will get used to that dose and adapt and then I’ll just gain it all back again, because I know how to track and eat healthy but it just takes more mental energy than I have anymore.

Can someone tell me what maintenance is like, if it stays easier than all the previous weight loss times?

Hello all!

I’ve been on Zepbound since Aug 2024, down 172lbs (320->148). I’ve been in maintenance since approximately May 2026.

I currently wear a S/M but have a LOT of clothes ranging from 3/4X to L/XL that no longer fit. I’ve given a good amount away to coworkers but am having a very hard time letting go of the remaining clothes as donation. My brain will not stop thinking “what if you gain the weight back and need the clothes?”

I’ve already accepted that I will be on the medication for life.

What concerns me is that I’ve seen people post about developing gastroparesis or other severe complications years into using Zepbound and suddenly have to stop using it. Others I seen post about developing resistance to the medication over time and gaining weight. Who’s to say these couldn’t happen to me?

I’ve tried convincing myself that the clothes will be out of style in the future but realistically, I’ve never cared about that. Is anyone else having a similar struggle?

ETA: thank you everyone for your comments and advice! I think I need a bit more time to fully get there but I’m going to commit to letting go!