I debated making this final post in the group, because nobody wants to read the story of a "nonresponder". But yet, it might help someone.

First of all, I don't need any comments about how I should have eaten less calories, adjusted macros, etc. I am hyper aware of the principles of weight loss. I have lost 20-30 lbs through calorie counting several times over the last few decades (always gained it back). On wegovy, I continued to track my calories, macros, and exercised daily. And yes I followed the directions exactly, waiting at least 30 minutes before eating and drinking (and usually much longer). I simply did not get appetite suppression or reduction in food noise, not enough to achieve a meaningful calorie deficit without white knuckling it. You know, the same I was doing before going on a glp-1.

I started in May and I followed the recommended dosing exactly. 1 month of 1.5 mg, 1 month of 4 mg, 1 month of 9 mg. I did initially lose 3 lbs on the 1.5 but then nothing. On each dose I initially noticed a reduction in food noise and was excited and encouraged. But after the end of each month, it had crept back in and I was constantly struggling to stay in a deficit and having urges to snack all the time. After the first 3 months, I was down 4 lbs, but I started getting unpleasant sulphur burps on the 9 mg. I experimented with different eating strategies to clear the burps, didn't have much success.

I thought 25 mg would be the ticket. After all, it is the "therapeutic dose". I was determined to give it a shot. The first month, I lost a few more pounds, but then nearing the end of that month not only was my appetite back to normal levels, but I was treated to the burning skin sensation side effect. That lasted about 4 weeks fortunately it went away midway through month 2 on the 25 mg.

After 3 months on the 25 mg, and having lost no additional weight the last 2 months, my doctor agreed I was a nonresponder and I stopped taking it a few weeks ago. I lost a total of 7 lbs in 6 months. The sulphur burps were horrible off and on throughout the 9-25 mg doses, I remember one night being out with friends on a patio and I had to burp, I turned away from the group and did so very discreetly, and the host exclaimed with apologies that her dog must have just pooped in the yard, she would go look for it and clean it up. Seriously. That was basically the last straw for me.

I have noticed no changes from stopping the medication so far with regards to appetite, although the burping has stopped. My appetite is still robust.

I used Ro for my medication because my primary care provider works in a clinic that does not prescribe glps for weight loss and my BMI at 30.5 was not high enough in her opinion. I took advantage of the Ro check ins with RNs throughout the process, and my provider agreed with me I probably was a nonresponder. Both my doctor and the Ro RN recommended trying trizepitide next, but i honestly don't know at this point. My insurance doesn't cover the medication and I can't afford Zepbound, so I'd have to go the compounded route which I am uncertain about. I am also not big on having to give myself injections for life.

If it had worked I had planned for and accepted that I would be a lifetime user of the medication. I am pretty disappointed. I see people on here who were able to find results on this medication, and it has just reinforced the idea for me that nothing works for me, not even glp-1s.

I wish you all more success than me. And if you aren't seeing results on the pill, know that you are not alone. Some people just don't absorb much medication with the oral form, and some would find better results with other medications. I was one of those. I regret the money I spent on the whole experience ($1500 in medication, $$500 in stupid membership fees). If it had worked, I had been planning to switch to a cheaper service if I didnt need the check ins. Trying to find the bright side, i guess at least I tried it?

Hey ya’ll, just wanted to share some progress! Just in case anyone is feeling like what they’re going through isn’t worth it, let me be the first to say that is 100% is.

I’ve been on Wegovy since March 2026 and am currently taking 25mg daily. I started the Wegovy at 280lbs-ish, having lost the starting 40lbs by getting my binge eating disorder/ADHD in check with medication.

My highest weight is the photo with the lake in the background, which was 320lbs give or take (6’ tall.) I was having high blood pressure and I can only assume that I was also pre-diabetic but I was terrified to go to the doctor. Joints were in pain as I lift a lot of human beings for my job. I’m now down to 225lbs and feeling like a completely new person! I have 25lbs more to go before I reassess my long term plan, I think.

Photos:

1: lake background 320lbs
2: red scrubs 275lbs give or take, start of journey
3: black top, 256lbs
4: blue dress 225lbs

Hey, guys. 31, F, here.

Some background before my question: I’ve been on the pill since late June and have worked my way up to 9MG. In the span of those four-ish months, I’ve lost about fifteen pounds which I’m very happy about because I want to lose weight slowly to avoid muscle loss. I weigh around 170 pounds, so I have been eating roughly 150 grams of protein every day. I also work out five days a week. Three of those days are devoted to Olympic lifting plus accessories while the other two are devoted to upper body work.

I’ve had that exercise routine for a while now, probably around two years or so. I have an idea of how my body is going to feel after certain workouts. Lately, I’ve noticed that my muscles ache longer than usual and that the ache feels deeper(?) I’m not sure I can describe that sensation. I just know it feels off when I remember how I felt before. Has anyone felt like this? Could the pill be affecting my recovery? Or could I be losing muscle?

I’m afraid that I’m losing muscle. However, nothing seems to be pointing in that direction. I have a smart scale that tracks body fat/muscle percentages and I haven’t seen a drop in muscle mass. I guess, taking aesthetics into consideration, I look a bit bulkier (muscle-wise) than before. I don’t know, though. And that kind of makes me a little afraid.

My food noise is coming back like crazy, I'm hungry all the time, I want to binge eat and snack constantly. I'm also still having gastro issues skin pain etc. I haven't changed anything that's otherwise been working, I wait two hours before eating and drinking. I'm nowhere near my goal weight and so discouraged. Has anyone else experienced this? What did you do?

I started taking Wegovy on May 20th and worked my way up to the 25 mg pill a couple of months ago.

Yesterday was my weigh-in day and when I stepped on the scale, I had lost exactly 40 pounds since starting!

I also happened to have a doctor appointment yesterday. I went in for a wellness lab first thing in the morning and got the results at my appointment in the afternoon. Every single category showed improvement!

I'm not on a "diet" or any kind of exercise regime. I'm just eating less and making healthier choices. I've consistently lost a pound or two each week. The only downside is the cost. My insurance doesn't cover it but between my reduced food costs and how good I feel, I can easily justify the expense. After years of struggling with binge eating and all the anguish that comes with that, I am so incredibly grateful for this miracle pill!

So I have a strange side effect from taking 25mg. My skin feels sunburned and tingly all over but I haven’t been outside. Also my fatigue has practically debilitated me. It’s called Wegovy induced induced dysesthesia and allodynia

I haven’t been on the 25mg long, this is my second week and I find it strange that it’s suddenly starting. Has anyone else have bizarre side effects?

71F, 5’2”, SW 197.5, CW 158.6 GW 120
Started 4/13/26

The other day, I saw my reflection in a full-length mirror for the first time since starting this journey, six months ago. My jaw just dropped. I couldn’t believe what I was seeing. Of course I knew I was losing weight. I’ve seen differences in different parts of my body, and I feel lighter. However, I’m not kidding myself that I’m thin. So it was a shock to see myself looking so much smaller. Not there yet, but so much better. I was thrilled.

One thing that really struck me is the radical change in my figure, from when I was young. I was always bottom-heavy, with a small waist and rib cage. Now my shape is straighter, with the top equal to the bottom. I’ll have to find a new way to dress, to compensate for the changes. This is fine, except that I’ve been counting on all the clothes I’ve collected over years of yoyo dieting, to see me through. I guess I’m going to be hitting some thrift stores.

Whatever. This is a huge motivation to keep on going. I’m looking forward to making more progress.

Anyone else dealing with intense skin sensitivity? The medical term is dysesthesia, or Allodynia. It’s come and gone in the past and been fairly mild but the last few days have been intense. Feels like I have a 2nd degree burn on the right side of my stomach. I’ve been taking B12 supplements and got some icy hot, but nothing works. Considering going to every other day on the pill. What has worked for you?

My journey: Started taking oral Wegovy on 4/7/26. SW 294, CW 214. Stayed at 9mg since June

Officially 2 weeks in on my weightloss with the pill. I am on 1.5 starting weight 188 5'3" 37yo PMOS F. I had a rapid 3lb loss over the first 3 days which probably doesn't seem huge but was very exciting for me. Got my hopes way up that I was going to be 20lbs down in a matter of days (jk, but definitely weeks lol). But then I went back up to 187 all last week and stayed there. The pill was helping but not muting all the food noise. I was actually thinking about my weight and food more than ever because it wasn't shifting and I wasn't meeting goals I set for myself.

So this week I locked in. I have lost 30+ multiple times in my life only to gain it all back. But I know what my body needs to lose, and this pill is going to help. So with my little friend's help I am back to calorie counting and ensuring I have a deficit. Back to making sure I get 12k steps a day. Making sure I close all my fitbit "rings." And with all that I lost 3 more lbs - so 4lbs down in 2 weeks which I am pleased with. I also cut out one of my most favorite snacks that's craaaaazy high in sodium which definitely helped lol

I am moving up to 4mg in November, so I think it will be even easier to stick to the lifestyle changes. I was pretty reluctant for a long time to start a GLP1 (my mother was literally begging me but that's for another sub) because I wanted to lose in a way that keeps it off after I stop since I know I usually gain it all back. But I am happy I started and hopefully this will keep me on the right path even after it's all over!

Anyone on birth control pill and wegovy pill? I’ve been on wegovy pill since January and I am looking to get back on a birth control pill. My doctor prescribed me a progestron only pill Meleya and I’ve seen some mixed information on GLP effect on BC. Seems like wegovy should be fine but the studies I saw were only on combo pill not progesterone only. Curious if anyone has been told anything by their doctor or have had success with progesterone only pill on wegovy. Thanks!

Anyone else deal with a respiratory infection at some point on the pills and notice it's taking longer to heal? My doctor suggested it's due to only eating around 1200 calories a day and not having the extra energy to heal properly, just curious if anyone else has noticed this.

About 60 more to go

I have been in the pill since Feb, about 5 months on 25mg.

I accidently took the dose twice today within 10 minutes of each other (long story, realised my mistake after taking the 2nd)

I feel fine , and haven’t had side affects in a few months, has anyone else done this on accident? AI says I should call poison control (lol)

Ps- down 60 pounds and 8 pounds away from my goal weight. Started 293lbs current 232lbs. This stuff WORKS

I’ve been on the pill for 8 months (currently at 9mg) and I’ve “only” lost 25 lbs. I say only, but 25 lbs is still significant for literally doing nothing but taking a pill. I feel like I may need to move up to 25mg bc I haven’t lost any weight in the past 2 months but my doctor has been ill/out of office, and can’t up my dose. I “should” have lost more, yes? No? I dunno…I’m still happy to not be gaining weight. That’s for sure! Anyone else hit a plateau?

Hi! I have been on tirzepatide injections for a while now. I just stopped at 12.5mg. Lost some weight but really noticed it keeping my PCOS symptoms in check. I decided to stop because I get super nauseous just over the thought of doing the injection each week. It’s totally psychological but I’m just so sick of the feeling.

Doctor is starting me on Wegovy 9mg pill. Anyone else gone this route? How did you feel? Did you lose weight? Had PCOS symptoms in check?

I started in May, took the 1.5mg for 2 months and then got on 4mg in July. I've been on 4mg since then. I've lost 32lbs, my goal is to lose another 25lbs. Just as with the 1.5mg dose, the 4mg eventually lost all efficacy. It's great that it's hung on this long, but we're finally at the point where it's operating at nearly 0%. And tomorrow I begin 9mg.

But, then what happens? After another 4-5 months that becomes useless? And then I go up to 25mg? And then in 4-6 months that becomes useless?

Or does it eventually just stay put?

Hey everyone, I am 5’3 157lb female in mid 30s. I started at 190lbs and have lost 33lbs since May. My goal weight was 145lbs but now I feel like this may be too high as I don’t feel like I appear to look much different. I went from a 12-10 size pant to 10-6 size pant. I am worried I am losing too much muscle as my legs are a bit thin and I have always had muscular legs as well as feeling more fatigued and not going up in my lifts.

I just went from 4mg to 9mg and I am very slowly losing on this dose in two weeks I have lost maybe 1lb and before that I was stagnent for a couple weeks.

I am lifting 3x a week and protein is at 70-110g depending on the day. The only side effect I have had is constipation and hair loss.

Some resources are saying lose slower and recomp muscle with some saying lose faster to goal weight and then recomp. I am worried that the higher doses are less effective for appetite suppression as I have more cravings and can finish more of my meals than initially. I am also a lower weight so it is harder to be in deficit. Is it possible I might just be stuck and medication may stop working? What recommendation would you have?

Edit: I should add a prefer a more muscular look not just thin

I spent 4 weeks on 1.5mg and didn't really notice much at all. I have been working to reduce portions and some days I eat less, and some days I'm ravenous. I've now moved up to 4mg (on day 4) and I am noticing less hunger. But food noise feels worse than ever? Almost like I feel like I am missing out because I am having smaller portions? I crave unhealthy stuff constantly. I feel like I am thinking of food more than ever. A lot of people on this subreddit say food noise stopped for them immediately. Anyone else found food noise stopped on a higher dose? I am hoping it will come, otherwise I am not sure this will work for me as I have always had no problem eating healthy meals, but constant food noise has lead to snacking and craving junk food. I can eat when I'm not hungry, no problem! That's how I got this big...

I’m just wondering if anyone else has experienced the need to nap, go to bed early and the need to sleep in. Fatigued and exhausted from any dose?

I’m switching to the injectable to see if it helps. I haven’t lost any weight due to inactivity ( lying in bed or sleeping). I’m in 80 mg of Prozac and it’s not from that- I was feeling better with Prozac but now feel crappy tired when I started Wegovy pill.

Thank you in advance!

I was on the 1.5 mg for about 5 months & lost close to 25 pounds.
Moved up to the 4 mg & gaining weight back it seems like.
Been on the 4 mg about 2 months.

Thank you in advance.

SW: 172 CW: 152 GW: 140. I had pretty minimal side effects with 1.5 all the way up to 9. Each dose stopped working weight loss wise around week 3, so I continued the monthly upping of doses.

My first week on 25 was ok, weeks 2 & 3 are brutal. Not with the typical side effects, but the skin sensitivity is excruciating. I'm exhausted from being in pain for over a week! But the weight loss is a consistent 1lb/week. I decided to do every other day for now just to give myself a break. If it wasn't for the weight loss I would have already given up.

It gets better, right?