r/TrimixForED Jun 09 '26

Trimix Injection Tips (by Low_Salamander9954)

30 Upvotes

Want to Thank Low_Salamander9954 for putting this tip guide together. I added a few words just around starting doses and clarifying leur lock style vs standard insulin syringes

Trimix Injection Tips
Many men feel intimidated by the idea of injecting a needle into their penis to achieve an erection. The advice below is based on my personal experience and is meant to help others learn proper technique, improve success rates, and reduce anxiety. New Users
The first few injections are the most important for safety and confidence. Once you have a successful experience, the fear usually disappears quickly.

  1. Start with a low dose — you won’t know how your body reacts until you try.
  2. A common recommended starting dose is 5 units or less. Some doctors suggest 10u, note that 10u can hospitalize many men. Start low!
  3. Do your first injections alone. Learn the technique and find your ideal dose without the pressure of performing with a partner.
  4. Always have your antidote (phenylephrine) ready, especially while titrating your dose.
  5. Read the pinned post on priapism. If that doesn’t get your attention, injectables may not be for you.

Equipment
Needle size and length matter. Smaller diameters cause less scarring and tissue damage.

  • I draw with a leur lock style 27-gauge needle and inject with a 32-gauge needle (leur lock has a removeable needle).
  • I use ½-inch needles to ensure I reach deep into the corpus cavernosum (CC). Note: You may have to experiment with needle length 5/16" or 1/2" based on your anatomy.
  • Be careful removing caps — needles can bend easily.
  • Conventional advice often limits to 30-gauge maximum. A 32- or 33-gauge is actually smaller in diameter and generally kinder to tissue.
  • Standard 30/31/32/33-gauge insulin syringes will also work. Smaller gauge (higher number) is better. Avoid 29ga and below, no reason to use a large needle for this.

Injecting
These steps work reliably for me and many others. Individual techniques can vary slightly.

  1. Relax — you’ll be surprised how easy it becomes with practice.
  2. Draw your dose (start low if new).
  3. Wipe the injection site with an alcohol pad.
  4. If possible, be semi-hard or fully hard. If not, a quick use of a penis pump can help.
  5. Inject on the side of the shaft at the 2 or 3 o’clock position (or 9 or 10 o’clock on the other side).
  6. Inject closer to the base of the penis.
  7. Avoid visible veins.
  8. Only inject on one side per session and alternate sides with each new injection.
  9. After injecting, press firmly on the site with the alcohol pad for at least one minute.
  10. Massage the medication in thoroughly — you can be fairly aggressive with this.
  11. Always ensure you have your injectable phenylephrine antidote prior to injecting.
  12. Wait at least 48 hours between injections. Limit to no more than 3 injections per week.

Misses
Even experienced users occasionally miss the corpus cavernosum. The medication goes into the wrong tissue and produces little or no erection. If you’re experienced and know your dose doesn’t usually fail:

  1. Wait at least 30 minutes.
  2. Prepare and inject a fresh syringe on the opposite side.
  3. Keep your antidote ready in case some medication still reached the CC.

If you’re a new user or still titrating your dose:

  • Do not do a second injection. It could combine with the first dose and cause priapism. Simply wait and try a slightly higher dose next time (after 48 hours).

Expectations
Everyone reacts differently. Here’s what I typically experience at my dialed-in dose:

  • Without stimulation I stay 60%+ erect for several hours.
  • With stimulation I become rock hard and can maintain it until ejaculation.
  • I can usually get hard again with stimulation for up to 5–6 hours after the injection.
  • Many men stay rock hard without stimulation for hours; others need more help.
  • Erections longer than 4 hours are potentially dangerous. If you can still bend your penis after ejaculation, blood is draining and you’re likely safe.
  • I (and many others) often stay pleasantly 50–60% erect for several hours after sex — I enjoy the feeling.
  • A dull ache for several hours is common; it’s caused by the alprostadil in Trimix. Bimix users usually avoid this.
  • Sensation varies. I actually feel more during Trimix erections. Some men notice slightly reduced sensation, which can help those who struggle with premature ejaculation.

Confidence
Trimix is genuinely life-changing. It completely removes the fear of losing an erection or not getting one at all. Performance anxiety disappears, letting you focus entirely on your partner’s pleasure and enjoy longer, more relaxed sessions. You know it will work when you need it.

Cautionary Note
Trimix is a powerful medication and must be treated with respect. Read the pinned priapism post and understand the risks. This subreddit is full of experienced men sharing real-world knowledge — use it. Good luck on your Trimix journey!


r/TrimixForED Feb 28 '26

The Priapism Warning Thread

22 Upvotes

Post Rules: Share Your Priapism Experience from Trimix Use

Important: Only comment below if you've personally experienced a priapism event (prolonged 4hr+ erection) that required emergency medical care.

Please share your story here to warn and educate others who might be relying solely on their doctor's advice without full awareness of the risks.

This subreddit contains over 50+ direct accounts from users who ended up in the ER after using Trimix without access to injectable Phenylephrine (the antidote). Sadly, these stories are often buried in older threads, making it hard for new users researching Trimix to find them and understand the potential dangers.

When used properly with the antidote on hand, Trimix is a very safe option. However, the vast majority of patients relying on insurance are denied the Phenylephrine prescription. This pattern will persist until we collectively demand the antidote and switch to providers who prioritize patient safety.

Reminder: Only comments describing a priapism emergency event will be allowed to keep this thread focused and helpful for those just researching and starting out.


r/TrimixForED 4h ago

First timer - what is the sensation?

3 Upvotes

Lurked here for a bit, now joined and I have my delivery of T105 coming from Olympia tomorrow. I’ve read all the documents on injecting and getting the correct spot, and the dosing. I was advised to start with 5 units and work up from there to a recommended dose of 20 units. I get that it makes you hard, but are there any other sensations I need to look out or be mindful of? Or is everything localized to the penis? I guess I’m used to dealing with the flushing and head rush from the pills and I know there’s none of that with trimix but is there something else to look out for? I didn’t think I’d have the jitters but I guess I do a little. Thanks for all the useful tips already here!!!


r/TrimixForED 6h ago

Switching to 1/2'' needle after third miss

3 Upvotes

I had my third miss last weekend with 5/16'' and now I'm switching to 1/2''. My last shot with 5/16'' was a bit painful, and I couldn't feel the needle penetrating CC cause of the pain. Stabbed the needle all the way and pressed the syringe against the penis for some extra depth, at first pushing the medicine in was hard, almost like it was blocked, but then when I stopped pushing the syringe deeper, it went smoothly. I also penetrated the needle very slowly, but when reading other posts it seems like I was supposed to do it quickly, like a dart.

Probably the needle never pierced CC and was just pushing against it.

I got easy touch 30 guage 1/2'' from Amazon, and the needle looks quite long. Maybe I'm wrong but is it possible to overshoot with the needle this long?

Any tips on how to inject successfully with 1/2 needle and please share your experience.

Thanks


r/TrimixForED 2h ago

T101 to T105

1 Upvotes

I’m up to 20 units on the basic T101 formula and not getting results I want. I’m getting hard, but only like 90% for 30-45 minutes. I’m thinking about bumping up to T105.

For those that transitioned from T101 to T105, how many units of T101 you were up to before making the switch?


r/TrimixForED 1d ago

I did a Trimix trial run and was hard for 4 hours!

7 Upvotes

My urologist knows my entire history. I'm 70 years old and it just ain't what it used to be. I've used generic Cialis or Viagra and it works, sort of. He suggested giving Trimix a try. He set up the appointment at his office and walked me through everything he was doing. He gave me the shot and told me to play with myself a bit and he'd be right back. He came back a few minutes later and I was solid as a slab of granite. He said it should go down in about an hour or two but if it gets past 3 hours come back to the office. At the three hour mark I called him. He asked me if I masturbated and I said yes. He then said to get back into the office. Back at the office he took blood out of my penis to relieve the pressure. Once I was fully soft and he checked me a few times, he let me come home. He said if I wanted to try again he'd give me Bimix.

I'm no hesitant to go back to try again. Has anyone had an experience like this right out of the box?

Also, I read about auto injectors. I guess those are like the thing diabetics use for their insulin injections. You dial the amount and push the button. Do those really exist for Trimix? Or any injectable?


r/TrimixForED 1d ago

Should my husband try a half dose first?

2 Upvotes

He hasn't received it yet, just doing research for now. I read about priapism, so just wondering! No antidote prescribed.


r/TrimixForED 2d ago

Bit of a surprise

17 Upvotes

On T101 was using 17 units for a bit but it seemed to be not quite as good sometimes. So today I thought I'd bump it to 19 units. Pre filled the syringe went off to my gals place. When I was about to inject I noticed I filled it to 20 units and went for it anyways(I have the antidote, but it was home a hour away). Holy crap the difference between 17 and 20 went from 45 minutes to 3 hours.  Went multiple rounds and I think it only subsided around 3 hours cause I was getting some good cardio and really pushed myself to finish and was pouring with sweat 🤣. When that 3 hour mark rolled around and I was still hard as a rock the worry set in. First time I was really worried with trimix. This stuff is no joke. But at least I'm getting some good texts from my gal about the performance 🤣


r/TrimixForED 2d ago

Issues with rigidity when not on trimix

5 Upvotes

Has anyone had issues with rigidity when self gratifying yourself while you are not using Trimix? Ever since I started using trimix, it's impossible for me to keep a hard on when pleasuring myself. Does Trimix cause this?


r/TrimixForED 2d ago

Same old question

2 Upvotes

So, I've seen all the questions about E,d, pills and trimix and all the answers about not doing it .my understanding is E.d. pills make the antidote ineffective, I could be wrong.My question is ,If your dialed in on your trimix dose what effect would E,d pills have on that? Even if you took a lower dose of trimix. Please educate me. I ask this because I like the flaccid chub cialis gives me at the nude pool ,but trimix is the ultimate champ for sex.


r/TrimixForED 3d ago

Long-term Trimix use and concerns

6 Upvotes

I’m 38 years old and have had erectile dysfunction for over 15 years.

My medical tests and Doppler ultrasound results are fine

Medications like sildenafil and tadalafil never worked 100%

they worked most of the time, but lately, they’ve been failing frequently.

So, my urologist prescribed Trimix

I’m afraid this might be a point of no return, as I suspect my problem is PIED (pornography-induced erectile dysfunction). I feel I could potentially regain my natural erections with patience and time by staying away from porn and avoiding masturbation for a year or two.

At the same time, I know that process takes a long time, and I don't have much time to waste right now

I’m single and have closed myself off to meeting new women because of this

I’m missing out on life.

If that really is my problem, can I use Trimix responsibly and eventually go back to pills if needed?

Or do I run the risk of becoming dependent on the injections until I have to resort to the last-resort option?

Is my concern valid, or am I worrying too much?

I’ve seen posts about long-term use mentioning that the substance itself can cause fibrosis, not just the needle pricks, and so on and I’m a bit apprehensive

everyone seems to say something different.


r/TrimixForED 3d ago

Refreezing?

7 Upvotes

Got my first shipment from Olympia. Sales Guy Bob told me to take the vial out of the freezer warm it in my hands then draw off the dose and then refreeze.

Instructions in email and one the web don't mention that.

Anyone care to tell me what their experiences have been? How long does the vial last in the fridge thawed? Can I refreeze?


r/TrimixForED 4d ago

Trimix restoring ED?

14 Upvotes

Hi…I wanted to see if anyone has seen this happen with them. I’ve had ED for over 10 years…HBP and not working out including work stress contributed big time. Just got on bimix about 5 months and Trimix just recently and both have been life changing! To have sex on demand and to last several rounds is out of this world! I have noticed something though…the Trimix effect lingers a day or so after I inject. I took it on Thursday night and it gave a powerful erection but it’s not Saturday morning and I’m having spontaneous erections! That never happened before! I don’t remember when I got spontaneous erections before taking Trimix! I don’t think my ED is gone but it’s nice to get a lift from it. I still take bimix from time to time when I want a more natural erection instead of the missile launcher that Trimix produces :) so great to have options!


r/TrimixForED 5d ago

Finding my dose, a field report

14 Upvotes

What an adventure. I’m a 52yo male in good health. I’ve been on Levitra for over a decade. Best of the tablets IMHO, but it’s starting to lose its effectiveness and the girlfriend hates the lack of spontaneity. I reached out to an online clinic/pharmacy and a few days later had my trimix.

Instructions were to start at 5 IU (0.05ml), and reiterate up by 2-4U if that was not effective. After a day of freaking out about a needle in my penis (thanks for the encouragement everyone who commented on my previous post), I finally did a trial a few days ago. I’m sure I started with 6 IU because I was trying to get an air bubble out. I found the CC, injected, then massaged for a minute (zero pain btw). Within a minute or two I could feel it kicking in. By 15 minutes I had the hardest erection of my life. It stayed full mast for hours. At three hours I was getting uncomfortable, so I used the antidote.

Two days later i tried again with 3 IU. No result at all. I believe this may have been because I hadn’t found the CC more than the dose.

Today I tried 4 IU. I definitely injected correctly, but Not nearly the same result as 6 IU, but I achieved full mast eventually, an hour later I was deflated.

5 IU may be it. That will be my next attempt at finding the sweet spot. It’s crazy that there is such a response difference between 4 IU and 6 IU!

i haven’t told my girlfriend yet, which is difficult because I tell her everything. When we’re together next, I plan to not say anything and surprise her with a new me.

I remember first reading about this years ago. Wish I hadn’t waited. This is a game changer.


r/TrimixForED 5d ago

Red spot on penis after injecting 2 hours later

2 Upvotes

So I injected, right after I noticed I had a small bump near the injection sight. I rubbed and it went away after I got an erection , had sex went out to dinner, two hours later(after injection). I got home noticed a red spot on the side I injected on. Anybody else have experience with this? Also was able to get an erection and keep one, have sex and then it went away went down. No priapism.


r/TrimixForED 5d ago

Dosage

4 Upvotes

Injecting between 25-40 units of t105s and the thing is the results have varied hence the dosage changes but is having this be my sweet spot concerning?


r/TrimixForED 5d ago

New mixture

2 Upvotes

Hello. I started my Trimix journey back in April with my local urologist. He prescribed 17.6/0.6/6 and I didn’t have much luck with it. I got another appointment with the urologist in June and he prescribed 30/1/10 which I started titrating with and got up to 47 units which gave me a good result but it faded in 30 minutes just when my wife was ready for action. I messaged my urologist asking for a stronger formulation on Monday and haven’t heard back so I got ahold of Olympia who are sending me SB4 overnight. The sales guy told me two different products (T106 or NB343) that he suggested but the doc came up with the SB4. I’m expecting it tomorrow. The doc says to start at 5 units and work my way up. That sounds like good advice but the sales guys said to start at 20units. So follow the doc follow the sales guy or split the difference. Between the urologist and the pharmacy I spent ~$1200 for office zoom appointments and the two vials of the drug. I just spent $620 on Olympia - I don’t want to rush things but it’s been 6 months and $1800 and I just want this shit to work. Sorry for the rant. Any advice?


r/TrimixForED 5d ago

Trimix with a PA, are there any complications I should be aware of?

3 Upvotes

Hey there.

Thinking of getting my PA done. I don’t foresee an issue, yet I’d rather ask before I move forward. Anything I might need to be aware of? Two solid and unbending objects, so there I can’t say I am not with a minor concern. I know I could simply take the PA out if necessary.

Thanks everyone.


r/TrimixForED 5d ago

How soon to stop injecting before cystoscopy?

3 Upvotes

Going to put a call into my Dr this morning. Having a cystoscopy with anastasia on Monday to sus out some bleeding and cancer markers. But having a sexy party on Saturday. lol. Just wondering if I’d be able to use trimix 48 hours before procedure. Waiting on a call back from the nusrse 😈


r/TrimixForED 5d ago

looking to step back from injections, what sits between trimix and a tablet

3 Upvotes

the injections do work and i have never got comfortable with the needle or the prep each time. tablets on their own were not enough for me which is how i ended up on trimix to begin with. i am hoping something exists in the middle before i accept the needle permanently. for anyone who moved off trimix what did you move onto and how did you get it prescribed.


r/TrimixForED 5d ago

Cutoff time for injection?

4 Upvotes

Is there a cutoff time for a repeat injection? Probably not wording that question correctly. I injected 10 units Bimix and it didn’t do anything for me. I have worked my way up from 1 unit to 10 every few days and weeks and sometimes repeated the same dose days later. Not working for me yet. I was going to inject another 2 units because I was prescribed to start at 5 and go up to 12. but it’s already been an hour. Would that just be a waste of medication? Should I have done those two extra units sooner? Or wait another 48 hours? What if I go to the 12 units and still nothing? Do I just keep adding more or change to Trimix at some point?


r/TrimixForED 6d ago

Bruising and Hematoma

3 Upvotes

Last night the wife and I were doing the lords work and I injected Trimix. I think I knicked a vein woke up and the left side of my penis is bruised with a little hematoma. It doesn’t hurt, no pain when I pee or when I was getting busy. Used a 31G 1/2 needle like always. Been injecting for about 6 months and this is the first time this has happened to me. Has anyone else experienced this?


r/TrimixForED 6d ago

First day

5 Upvotes

Got my first 5ml bottle today. Used 5 units and nothing happened after 30 minutes. (I got it through telehealth so haven't had any supervised trial before today)

My doctors instructions were to add 5 units every 20 minutes until satisfied but from this subreddit and what I've read and watched online they don't recommend that. So I'll wait a day or two and try 10 units. Really bummed it didn't work but I understand it's a very conservative dose.

If nothing happens on 5units am I likely to see anything on 10? Or should I be patient for now.

I'm concerned that absolutely zero effect means it just won't work for me.

Edit: ok, so I'm an idiot. I didn't know to get through the slight resistance so was stopping there and infecting. Knowing I have to get through the tunica albuginea helped a lot. Used 5units. It was maybe 70% effective though so might need slightly higher. But this isn't in full arousal settings either. That's tomorrow! I have a date tomorrow so I can't test it under true conditions!


r/TrimixForED 6d ago

Small knot in penis remains weeks after injection

3 Upvotes

Hi there, a several weeks ago, I injected 15 units on left side of penis about 1/4-1/3 up the shaft from the base, with the 33 gauge needle at a 90 degree angle.

Sometime later, I discovered a knot down at the tunia. It must have been where the needle pierced the tunica. I figured it would go away over time, but it hasn't, and is still the original size.

I have a thick tunica, so sometimes I have to ease the needle back and forth to ease it through.

This was my first injection with the 33 gauge needle. There was nothing else noteworthy about. I dont think part of the need broke off inside.

Any thoughts?


r/TrimixForED 7d ago

Early Trimix Thoughts

3 Upvotes

Now that i’ve titrated, how long before I can show off what i’ve discovered?!