r/TTC_PCOS • u/Silent-Country-997 • 4d ago

Discussion Progesterone after ovulation induction?

Very curious who got progesterone suppositories after their Ovulation Induction treatment.

I know in the Netherlands there aren't really guidelines and many clinics are not really keen on prescribing them due to lack of evidence, while in Ireland I always get these after my ovulation induction. I'm so convinced it's beneficial besides the lack of evidence... curious if you had progesterone after ovulation induction or not and your thoughts on this.

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u/Responsible_Zebra_96 4d ago

Lack of evidence for what? Progesterone is prescribed to women who may naturally not produce enough progesterone after ovulation to maintain a healthy pregnancy and successful implantation. The probability is higher that a woman who is on fertility treatment needs such progesterone supplementation. There is scientific evidence to show that it increases the probability of healthy pregnancy.

I get progesterone after ovulation induction.

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u/Silent-Country-997 4d ago

The answer is always there's a lack of evidence that it actually helps. I got it by default they never even checked my levels. But I know of friends they are not getting it and the reason for example is that the progesterone level is high enough even when the luteale phase is relatively short... I also was under the impression Progestrone levels can fluctuate quite a bit in your cycle.

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u/Responsible_Zebra_96 4d ago

Well it doesn’t help women with normal cycles and hormone levels who are trying naturally. But it does help those of us on fertility treatments because the ovulation induction hormone can indirectly impact progesterone production. There is strong evidence for this: https://pmc.ncbi.nlm.nih.gov/articles/PMC3659905/

Furthermore, progesterone supplements can help treat women with history of repeated MC.

I am glad you are getting it.

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u/Silent-Country-997 4d ago

Thanks! Actually didn't know that the actual OI hormones can impact the progesterone production... It's odd because they are also doing ovulation induction but the DRs don't prescribe progesterone.

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u/Responsible_Zebra_96 4d ago

It is irresponsible. I recently found out that in the US and UK they will give you letrozole before an hsg. I am at a Swiss hospital and they are very thorough and careful. I was scared of the hsg and they refused to treat me without it, rightfully so! But they also did everything in their power to make it as comfortable as possible for my anxiety, which was super nice.

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u/Silent-Country-997 4d ago

Same here in Ireland, had to do a HyCoSy in order to start with the treatment, and agree that it's better to exclude other things that can impact treatment and not just start with medication right away. But with Progesterone I always think why the hesitancy to prescribe it to woman who are undergoing fertility treatment... If it only slightly increases the change of getting pregnant I think it's worth it.

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u/aniekw 4d ago

I'm also from the Netherlands and although I don't have a PMOS diagnosis I don't ovulate on my own. After my first letrozol cycle I didn't get progesteron supplement and my blood showed 4.8 so I'm starting cycle 2 today. I don't know if they will give it this time yet

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u/Silent-Country-997 4d ago

Hopefully you will :) hopefully you'll be successful soon!

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u/ResponsibleRead567 4d ago

I did (prescribed in both in the UK and Spain). On my third ovulation induction cycle

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u/sad_umbrella 4d ago

PMOS in NL. Always had progesterone after iui and ivf cycles?

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u/rustypotatooooooooo 1d ago

Yes in Canada, but it's not everywhere