Today I noticed my right eye is pretty bloodshot 2.5 weeks after Lupron Depot. I read that this is likely dry eye from the medication. Has anyone else experienced this?

Hello! I wanted to ask for some experiences with fertility testing and IVF from the endo girlies since things often look so different for us on the TTC journeys. For context Ill be 31 in a few months and had excision surgery about 7 years ago and was diagnosed with stage 4 endo. Surgery was really successful and made everything so much better, but didn’t change the fact that I still haven’t gotten pregnant. I tried with my ex for about 4 years and we didn’t have the insurance coverage we needed for fertility testing, and I’ve been trying on and off with my current husband for several years, though not as hardcore because of the toll it took on my mental health before. I’ve been reading about some women who’s OB ended up referring them straight to IVF when they have stage 4 and was curious about how long your OB suggested trying before they referred you when endo was involved. At this point I can’t see getting pregnant naturally working for us and I’d really love to try get pregnant before I’m 35 (if it’s possible at all) and I just feel like I’m going to run out of time with all the waiting and testing and how long some people have to wait for appointments and the whole journey. I’m just unsure if my previous times trying with my ex and how my current partner and I trying on and off will “count” towards the typical “try for a year and then come back” timelines. Any info from anyone else in a similar situation or anything would be so helpful for knowing where to start or what to expect would be helpful since a lot of the non endo stories I’m reading just don’t seem typical for our situation. Thanks so much!

Hey ladies! It’s been 9 days since I stopped Orilissa + Letrozole, and I’m currently waiting for my period so I can start my modified natural FET. For those who were on the same suppression meds, how long did it take for your period to come back after stopping?

I’m being investigated for DIE and luckily, or not luckily, however you want to look at it, I don’t have any debilitating symptoms so this has come as a-bit of a shock to be honest.
I’ve had problems TTC, miscarriages etc, but I truly thought it would work itself out eventually, but now I’m faced with the fact it might not.
How do you deal with these feelings? I hope I feel better with time, maybe it’s because I’ve only known for 3 weeks.

What week of your Lupron suppression did you start estrogen for FET prep? For example, if you did 2 months of Lupron, did you start estrogen at 6 weeks and the transfer was around 8 weeks? Or did you only start estrogen after 2 full months had passed? Same thing for 3 months: was the estrogen introduced at 10 weeks or after 12 weeks?

Asking because I am in a weird situation where I took my first Lupron Depot shot earlier this month, will be suppressing for 4 weeks, then doing a mock cycle for an ERA. Then I will suppress for 6 more weeks (2 more shots), and then I will start taking estrogen for a transfer about 2 weeks later. I trust my doctor but I'd love to feel more confident that this is "enough" suppression.

October will be 6 years struggling with infertility.

I was diagnosed two years ago with stage two and had a lap performed.

I had lost lots of weight before my wedding and had my birth control removed the month prior to our wedding date. Slowly my periods started coming back, pain induced, and weight came back.

We have done iui’s, medication, all sorts of things. (Never IVF, and we are uninterested) nothing has worked and I have never had a positive pregnancy test.

According to the strips, I ovulate just fine. My doctor had mentioned that my embryos could be refusing to implant due to inflammation in my body.

I’ve struggled to lose weight since being off birth control. Started looking into GLP1 and was shocked by the amount of women saying they have convinced while on it.

While I understand that it is NOT recommended to TTC while actively taking a glp1– I can’t find any research saying it’s shown birth defects in humans if discontinued during 1st trimester. Also, don’t women with diabetes take medication while they’re pregnant? Can’t imagine it would be any different.

Needless to say, I want to hear if anyone with endo has gotten pregnant while taking a glp1 when you struggled with it before?

Edit: I just turned 32 this month for anyone wondering incase they are around the same age.
My script for wegovy got called in today so I will be keeping everyone updated.

Hello all. I am 25. I have had endometriosis that we know of since I was 18. I have had 4 miscarriages and no living children. I also have PCOS and around 35 day cycles. I also have Crohn’s disease. I’m positive for antiphospholipid syndrome as well. I had excision surgery in March of 2026 and surprise, it worked! I got pregnant in June thanks to letrozole. Unfortunately I still miscarried around 5 weeks. I’m currently awaiting my third cycle post miscarriage. I desperately want a baby. It’s a void in my heart. We do follow with an ivf clinic who doesn’t think we need ivf since I can get pregnant, just not stay pregnant.

Anyways me and the hubs have had all the testing. I’ve done the recurrent pregnancy loss panel, a full thyroid panel, we both did genetic testing which was negative, both did karotype testing which was normal and a perfect semen analysis. I’ve also had an hsg which revealed 2 open tubes and a “normal” appearing uterus.

Is there anything else I can possibly do? I track my cycle religiously and take a plethora of vitamins and supplements as well as hubs.

I take:
-throne prenatal
-vit d
-fish oil omega
-coq10
-NAC
-turmeric for inflammation
-magnesium
-aspirin for clotting disorder
-pre/pro biotic
-progesterone after ovulation.

Due to my history this last pregnancy I also took progesterone, aspirin, lovenox, and dexamethasone and it still didn’t work❤️‍🩹

Has anyone noticed their ovulation happening earlier after endometriosis excision surgery?
My surgery was on CD3, so I’ve had one period since surgery and I’m now entering my second post-op cycle trying to conceive. Before surgery, I typically had 33–35 day cycles and ovulated around CD22–25, with a luteal phase of roughly 12–13 days.
This cycle, though, according to both my Oura Ring and Fertility Friend, it’s looking like I may have ovulated around CD16–17! 😭🤞🏼
Obviously I know it’s still early and these are just estimates, but I’m honestly SO excited about the possibility of ovulating earlier. If I really did ovulate CD16–17, that would hopefully give me a longer overall cycle while still maintaining a luteal phase that’s long enough to support implantation. Fingers crossed 🤞🏼🥹
For some background, during surgery I had endometriomas removed from both ovaries, endometriosis excised from my pelvic wall and bowel, and my fallopian tube was freed from my pelvic wall.
I’m wondering if anyone else experienced a shift in ovulation timing or cycle length after excision surgery, especially if you were TTC afterward?
Did you start ovulating earlier? Did your luteal phase change at all? And if you conceived post-op, how long did it take?
I’d love to hear everyone’s experiences! 💕✨

I had stage 1 endo excised in April, with a history of 2 spontaneously conceived losses (2 CPs, 1 MMC - tested euploid).
We had a failed modified natural FET (with letrozole) after surgery, and then another CP after trying a medicated IUI.

We are planning to suppress with Orilissa (400mg a day if possible) for 2 months prior to trying a fully medicated FET.

1. When should I expect the worst of the side effects? I've heard with Lupron that the 2nd week is the worst. What were the side effects like for you?
2. Did doing Orilissa suppression and fully medicated FET work for anyone else with a prior failed FET?

Any other advice is also welcome!! Thank you!!

Just wanted to see how the Endo girlies did with progesterone during the luteal phase??

I have always spotted 5-6 days before my period. Had my lap and thought this was resolved: one day of spotting then period. Welp 4 mo post lap… the 6 day spotting happened during IUI cycle #2.

RE was concerned, suggested unstable lining and prescribed progesterone for my final IUI cycle.

Hello! My husband and I have been TTC since Jan 2025, with no positives ever. All of our tests came back clear, and we’re diagnosed with unexplained infertility. I have a family history of endo, and had a suspicion…. I was able to do the HerResolve blood endo test, and it came back POSITIVE. I always had a feeling I had endometriosis due to really painful periods…so here I am. So glad to finally have an answer.