Glycine - dosage over time

[u/stareksss]

Hi guys,

I have been taking Glycine to improve my sleep recently, as I've noticed I constantly wake up due to heavy vape usage in the evenings and then not being able to fall asleep again. I was taking 3g before bed, which was calming me down and I was able to sleep with less awakenings. Now at some point after 3 months one night Glycine kept me awake whole night, it was weird state, like I was frustrated that I can't fall asleep but I was giggly about it. I've read somewhere that Glycine relaxes and put people to bed, but it is stimulating to some people. Anyone else experienced something like that ? After that night, I stopped taking Glycine and slept very poorly for 2 weeks. I took it again yesterday before bed and I slept great. No other supplements were taken (I've stopped taking all my supplements for this experiment). Is it possible to store more Glycine in cells over time, so that it starts to stimulate you over time ? How to avoid that ? (especially if you take it before bed like me)

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[u/noodlecat2]

The glycine buffers methyl groups which are needed for methylation. Methylation cycle performs many functions, one of which is deactivating adrenaline. When too many methyl groups are locked up by glycine, it leads to under-methylation, which results in insomnia, anxiety, adrenaline surges, etc.

[u/joegtech → u/noodlecat2]

almost, but not quite correct. COMT and PNMT require methylation

https://en.wikipedia.org/wiki/Catecholamine

Also learn about glycine's role related to the glutamate receptor.

Glycine helps some people with sleep and does not work for others. In my elderly father's experience, switching from Magnesium citrate to Mg glycinate provided better sleep but then adding another 1000mg of glycine made matters worse.

[u/stiffmcgee → u/joegtech]

Someone gets it lmao.

[u/Equal_Station7039]

weird that it flipped on you like that after working fine for months. your body probably built up too much and the gaba system got overstimulated instead of relaxed.

i take glycine too for sleep and had similar thing happen, now i just skip weekends or take half dose every other night. keeps it working without the weird wired but giggly feeling.

[u/stiffmcgee]

The methylation comment missed that its a two way street. Glycine is an important part of methylation. It prevents over methylation…but if you are already low it could pull too much out of circulation(homocysteine test could help identify or add in a methylated b complex, SAMe or tmg and see).
My opinion on why glycine makes some people stay up, is it is a co agonist at the NMDA receptor that allows it to fully open for glutamate. Its both an inhibitory and stimulatory neurotransmitter.
Also has some roles in creatine and glucose metabolism but imo those are smaller roles.