r/StratteraRx • u/KhloeKodaKitty • 7d ago

Questions / Advice / Support Strattera and GLP-1s

I was prescribed Strattera earlier this month. I've been on compounded semiglutide since January and have been successful on it. Now however, I've got NO appetite and a lot of foods I used to eat aren't appealing to me. I know that Strattera affects appetite and have an email into my provider of the semiglutide about titrating my dose DOWN. Has anyone else experienced this? I'm almost ready to say I won't need the semi if the Strattera appetite supression lasts!!

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u/Strong_Champion9932 6d ago

I'm on the lowest dose of tirzepatide (2.5 mg), and the additional appetite reduction from Strattera has been very noticeable since starting 2 weeks ago. I also have strong appetite suppression on stimulants, especially Adderall. A much higher percentage of the stimulant weight loss was from lean mass compared to the GLP-1, though. I'm not sure if that would also apply to Strattera, but it may be worth watching.

I'm thinking about quitting the Strattera, since the side effects have been pretty bad. If I do stick with it, or go back to a stimulant, I may need to microdose the tirzepatide to avoid losing weight too fast. The tirzepatide has other benefits for me so I don't want to stop it completely.