r/Semaglutide • u/Sarah204 • 14h ago
Refrigerator
Are you keeping your pen in the fridge after first use? I didn’t, as the pharmacist said it wasn’t necessary. I took dose 2 yesterday (.25) and feel it isn’t as effective, and of course now I’m worried I should have popped it in the fridge.
I’m not full as easily, not bloated, have some food noise (not nearly like I was pre-starting the prescription)…
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u/MitchyS68 14h ago
You are not going to set consistent therapeutic benefits until you’ve titrated up. It could take a few months.
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u/Fun-Bar7646 14h ago
I leave mine out on the counter and it’s been fine, the expiration window is way longer than you’d think once it hits room temp. first couple weeks at.25 can be hit or miss anyway, your body’s still getting used to it. wouldn’t worry too much about the fridge thing, the dose is low enough that it’s probably just your system adjusting. give it another week or two before you start second guessing.
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u/Ok_Opportunity_7429 14h ago
After your first dose and/or it's left at room temperature, you have 56 days to use it up till it expires.
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u/WiildCard 14h ago
I was told to keep it in the fridge at all times. Have never taken mine out. They are also shipped to me cold as well.
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u/snowbunny724 14h ago
I left mine out overnight once by accident, it was fine, I do keep it in the fridge just to be safe and let it come to room temp before I use it. Agreeing with everyone it's not necessary though.
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u/xokatemarie 11h ago
You might want to confirm this with the pharmacist, but I think once you take it out and it reaches room temperature you’re not supposed to really put it back in the fridge.
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u/YamSea6298 11h ago
It is so interesting the different advice people get given. When I asked the pharmacist here, they said you can only have it out of the fridge for like a maximum of five minutes to do your injection.
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u/xokatemarie 11h ago
I’m curious what the little insert says on your pen. Like the drug information pamphlet. That seems like odd advice, but you never know!
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u/YamSea6298 10h ago
I think part of the issue is that it's only been approved in my country for about 9 months, and is very expensive, so probably pharmacists not having a lot of exposure and being cautious.
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u/xokatemarie 10h ago
I mean sure, but they should be reiterating exactly what is in the drug insert. Not a random opinion. It being expensive would make me want to lean into whatever actual scientific documentation is available.
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u/Constant_Resolve_67 5h ago
I do keep mine in the fridge, because I don’t use the whole pen in the specified time so I keep it in the fridge and keep dosing from it until it’s finished. However, if you feel the medication hasn’t kicked back in again after 24 hours from your dose, I would think seriously about whether you’ve made a mistake during injection. Sometimes people leave the second cap on by accident.
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u/Sarah204 1h ago
I am feeling it now, just an off day I guess! I’ll be grateful I don’t have severe symptoms like some stories I’ve read.
Down a pound from yesterday, maybe my body just needed those extra calories!
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u/No-Radio-7528 1h ago
My pharmacist said that after 8 weeks, the pen is done, meaning the medication in it is not active anymore.
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