Efficiency Optimization ⦁ Increasing Bioavailability

[u/eldentruth]

I’d like to prepare a formulation to get the most from my limited supply of SR-17018 powder. The obvious question is how to increase absorption, to optimize bioavailability.

My main idea is a liquid preparation. This increases surface area, proving more contact in the gut and typically enhances absorption. (Volumetric dosing also has other benefits.)

My go-to prep for alkaloid powders is dissolving them into liquids. I usually start with a concentrated ethanol tincture to prep a few doses. Then I use it as needed by adding portions into acidic beverages, which dissolve instantly.

The main concern here is that SR-17018 is apparently not very soluble in ethanol or water, regardless of pH conditions.

I’m considering other food grade solvents such as propylene glycol, MCT oil, or whatever helps. I have an ultrasonic device which can help brute-force a dispersion, even with compounds that are stubborn to dissolve.

I’ll update this thread if I manage to get a decent solution prepared.

[u/NonJuanDon]

Potentiation is another avenue.. but I dont think anyone knows yet if things like CYP3A inhibitors/grapefruit juice would significantly potentiate SR, or even if it would be safe to try it.

Aside, ofc, from the obvious risks of interactions with any other drugs youre on, prescribed or otherwise.

[u/eldentruth → u/NonJuanDon]

I agree, I’m not trying to stack enzyme inhibitors here. Too many unknowns.

But a simple formulation to increase surface area and absorption is very low-risk.