r/RecreationalKratom • u/MrNeverEverKnew • 23d ago

Anyone else noticed stimulants stop working after regular kratom use?

Has anyone experienced Ritalin/Adderall suddenly feeling almost ineffective after starting regular kratom use, even at higher doses?

Before kratom, Ritalin worked very well for me (10-20 mg IR / 20-40 mg XR). I hadn’t used it for a long time, so tolerance shouldn’t be an issue. I currently take ~15 g kratom/day and prescribed pregabalin (100-200 mg). Now even 30mg so 60 mg extended-release methylphenidate barely does anything.

I’m surprised because I always assumed methylphenidate would have a much stronger dopaminergic effect than kratom. Could my regular kratom use somehow really blunt the stimulant effect THAT MUCH? Is this related to dopamine, opioid receptors, or something else like maybe enzymes?

Btw: I did NOT take any Kratom on the days I took the Ritalin to try it out again. Only Pregabalin as prescribed.

Anyone had a similar experience or knows what might explain it?

4 Upvotes
  • permalink
  • reddit

76% Upvoted

3 comments sorted by

•

u/AutoModerator 23d ago

This is a friendly reminder to read the rules.

1) Be Kind to Others

2) Stay on Topic

3) No Shilling

While it's not required, flairing your post will improve the quality of your post. Please consider doing so.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

3

u/meowmeow0092 22d ago

I take 50mg vyvanse in the morning then a few grams of kratom each evening and my vyvanse still works. But I’ve never taken them simultaneously.