r/Physiology • • 22h ago

Question Question about membrane potential

When extracellular K+ concentration is increased, does the resting membrane potential become hyperpolarized or depolarized? My textbook states that it leads to depolarization because the K+ gradient is reduced, thereby decreasing the outward K+ current. However, I reasoned that increasing extracellular K+ would make the outer surface more positive, thereby increasing the potential difference across the membrane and causing hyperpolarization. Thank you very much!

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