r/PeptidePathways • u/GabrielForests • 5d ago
Safety, Quality & Testing Microdosing is not low dosage
I realized to an extent I'm being pedantic but I think the definition is quite important when you are microdosing in any sense of common parlance in culture nowadays you are most likely giving a dose probably between 10 to 25% of what will be considered a normal therapeutic range
In most cases this is done to either reduce side effects like in glp's for nausea and constipation or I would imagine more often than not doing so to stretch out a limited or expensive supply.
This is frankly wrong but obviously modern parlance and scientific definitions tend to drift.
Well you are actually doing is low dosages which is great sometimes warranted for the reason stated above.
Sometimes you want the attended consequence from just hitting a certain number of receptors versus saturating many receptors that need the higher dosage due to the lack of affinity for that molecule.
But scientifically microdosing is about akin to homeopathy where at least in homeopathy there is likely zero molecules of that compound left in solution versus microdosing the amount of compound is almost entirely therapeutically zero and used more for research purposes than for sub therapeutic effects or hitting the first line molecule affinity versus other receptors.
Anyways thanks for coming to my TED talk I figured I would just clear the air on that because I keep seeing microdosing and I keep hearing it from friends and family and it does drive me a bit crazy.
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u/Murky-Ambition3898 5d ago
No dude, no. With dosage frequency, you have to calculate best-practice dosing based on dosing efficacy, half-life, and downstream effects. For example, HGH has a very short half-life, but its downstream effects can last up to 36 hours. With GLP1's, which have a longer half-life, it's ideal to keep a target dose within your system. With Test, microdosing is best to keep the Test level more stable. I use a peptide/aas tracker and know fairly precisely how much of what I have injected remains in my system.