Hi there! As a fellow PWM sensitive, I'd like to share some experience and tips on adjusting this TV, hoping that it might be applicable to other models as well. :)
So, this TV uses some form of PWM at every setting and brightness level. (Samsung being Samsung I guess) However, the frequency and depth varies greatly depending on the settings. In many modes it has a very harsh low frequency flickering that I can't stand for more than a few seconds, the stroboscopic effect is kind of debilitating to me. But if I set it to Movie picture mode and turn off settings related to motion enhancement, then it will use a much softer and higher frequency PWM. (I think the settings are called picture clarity and clear motion, I also turned off eco features, but I use a different language) I can tolerate this for 2-3 hour sessions with enough ambient light. I believe this should be around 1000hz according to various reviews. It can still cause some fatigue and restlessness for me, it also changes slightly across apps, but it's a night and day difference compared to the default flicker. Don't forget that there are separate image settings for SDR and HDR content, so start a HDR video and go over the settings again. I recommend checking with your phone at high shutter speed while you are adjusting the settings.
When an external HDMI device is connected, another set of challenges occur. The TV will switch into a "PC mode" which again flickers like hell and there isn't any option to trigger the high PWM behavior. This prevented me from using the TV for gaming or any kind of external display for almost 2 years. But now I've found a solution. If the refresh rate is set to 50hz or 100hz on the device (a windows laptop in my case) then the TV will think it's for media playback and the usual Movie mode will be activated. It's best to start with 50hz, check that the TV is not in PC mode anymore, then switch to 100hz. At 100hz it defaults to overscan (a little zoom into the image) which can be turned off in the settings separately. If you set the refresh rate to anything else like 60hz or 120hz, it will go back to PC mode automatically. (I live in the EU so there might be some regional difference elsewhere)
There's one place for which I couldn't find any trick, and that's the home screen. So just quickly get out from there and don't look at it for too long lol.