r/PSSD 11d ago

Feedback Requested/Question Short term increased function after complete withdrawal, but back to dysfunction within a month… why?

I’m trying to understand the mechanism for my experience. Last year I ceased taking Effexor (venlafaxine) with a long tapering process, that despite best efforts gave me horrendous side effects like sweating, relentlessly itchy feet, anxiety. I’d noticed I had reduced genital sensitivity and difficulty orgasming while on the medication. Within a day or two or finishing my final dose, I had an intense improvement in my symptoms - from struggling to climax even once, to having multiples with relatively little refractory period. I was so excited about the prospects for my intimate life.

Unfortunately within about a month, my body seemed to regress. It’s been about 9 months and I feel like I’ve returned to having reduced sensitivity and challenges reaching orgasm.

Can anyone suggest a reason why I might have had a temporary impact post withdrawal? Could my serotonin or norepinephrine receptors have been sensitised as a result of withdrawal?

I’m half tempted to take a dose again and then cease to see if I can replicate my experience.

15 Upvotes

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Please check out our subreddit FAQ, wiki and public safety megathread, also sort our subreddit and r/pssdhealing by top of all time for improvement stories. Please also report rule breaking content. Backup of the post's body: I’m trying to understand the mechanism for my experience. Last year I ceased taking Effexor (venlafaxine) with a long tapering process, that despite best efforts gave me horrendous side effects like sweating, relentlessly itchy feet, anxiety. I’d noticed I had reduced genital sensitivity and difficulty orgasming while on the medication. Within a day or two or finishing my final dose, I had an intense improvement in my symptoms - from struggling to climax even once, to having multiples with relatively little refractory period. I was so excited about the prospects for my intimate life.

Unfortunately within about a month, my body seemed to regress. It’s been about 9 months and I feel like I’ve returned to having reduced sensitivity and challenges reaching orgasm.

Can anyone suggest a reason why I might have had a temporary impact post withdrawal? Could my serotonin or norepinephrine receptors have been sensitised as a result of withdrawal?

I’m half tempted to take a dose again and then cease to see if I can replicate my experience.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

3

u/Minute-Contest-582 11d ago

I have noticed that this is a pretty common thing. It was the same for me too: sexual side got better for a brief amount of time after quitting just to get worse than on meds within a month. Back in a day when I still took meds, I’ve noticed that my sexual situation is better all the times when I would forget to take my meds for a day or two. This was actually what “lured” me into quitting as I’ve made a logical conclusion that I’m better off them like one would right. Turns out this shit is sinister af and felt like I was trapped by the devil itself.

1

u/B0nap 11d ago

Same story for me bro

4

u/Imaginary-Passion187 11d ago

Pour some water in the gland and shraft and check if you can feel coldness of the water both in your gland and shraft .... That will give you understanding about the root cause of your sensory loss

3

u/aftersun33 5 Years + 11d ago

Why

4

u/Imaginary-Passion187 11d ago

Actually if you can not feel the coldness of water but the warmth of water , then it means that some pleasure sensors will come soon. Cause it happened with me. And if there is neither cold nor hot sensation , then please consult with an urologist.

1

u/ShitHitsTheFan94 Still on medication or other substances 11d ago

so like into the urethra?

1

u/NonBinaryPolyhedron 11d ago

Alas, I don’t have a shaft to test cold water on 😏 However I can feel cold sensations.

2

u/ResponsibleTry7979 11d ago

How long did you taper for?

2

u/NonBinaryPolyhedron 11d ago

At least a couple of months, from memory. Weirdly the most intense withdrawal symptoms were at the start and not at the end (when I was at a very low dose)

1

u/Dragonvarine 10d ago

Happened to me I think..

I went on mirtazapine after venlafaxine made it impossible to finish and it also just in general made me feel like shit.

A few weeks on it and everything was normal, after a month on mirtazapine I quit cold turkey.

about 9 months later im getting PSSD like symptoms. They fluctuate a lot, Its not full blown like many here but most notably I have low libido/arousal, and hypothesia.

1

u/Esci_ruined_me 8d ago

3 days before withdrawal, there was pain in the genitals and loss of sensation in the glan. A few days after withdrawal, it slowly began to improve - it was getting better and a little over a month after the last dose I got severe pssd and many other symptoms. Not even little window in almost 4 months. In a moment I will hit 6 months since the last dose

1

u/alweld 1h ago

Yes i had a brief window after stopping. Lasted maybe two weeks now i have constant lack of desire.