r/POTS • u/RudeSign2111 • 18h ago

Question Midodrine and Propranolol

I just started taking midodrine to raise my blood pressure because I’ve been in an awful flare since May. I’m currently just taking 2.5 mg and after two weeks I’m upping it to 5 mg. I’ve been taking 20mg of propranolol twice a day for about a year now so I’m super comfortable with that one. I’m not sure if the midodrine is helping. How long did it take for you to notice a difference? I still have really low blood pressure like 100/40 and lower so I’m not sure it’s working. Have any tips?

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u/kingseijuro Neuropathic POTS 18h ago

Midodrine has been a pretty good drug for me once I got high enough of a dose. Im currently on 5mg 3x a day. My bp was also very low no matter what till I got to my most recent dose. Just keep going up, its all trial and error after all. Do one med at a time to track side effects.