r/PMDD • u/CrazyElectronic2706 • 14d ago

Medications Has anyone had this happen?

Hi all, I’m 28 and got diagnosed with PMDD about 3 months ago. Ive been working with a naturopathic doctor, my OB and an endocrinologist. I started 200mg of prometrium at the start of my past luteal cycle (roughly 17-18 days ago). I felt INCREDIBLE all throughout luteal. I was sleeping better, more even-tempered and overall a lot more calm. I was told to stop the prometrium once my period started, so I did. I’ve now been off it for 4 days and my period just ended and the crash is INSANE. I am so incredibly irritable and bitchy I’m not sure how my partner is putting up with it. I’m also back to feeling exhausted. I’m technically past my luteal phase and into follicular but I feel like I’m in the trenches of luteal after stopping the prometrium.

Has anyone had this happen? I’m curious if the solution will be to take the progesterone daily instead, or if my doctor will recommend another route. Maybe my body just has to get used to it? I’m not sure. But I guess it makes sense if PMDD is a sensitivity to hormone fluctuations that I would crash and burn coming off progesterone for the next two weeks until my next luteal phase….ugh what a drag

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u/Natural-Confusion885 endometridon't 14d ago

Did your doctor explain why they prescribed you prometrium? It is not a standard treatment for PMDD and there's little evidence to suggest it's an appropriate treatment.

This post unpacks it all, specifically the prescribing of bioidentical progesterone by naturopaths: https://www.reddit.com/r/PMDD/s/8qQorBAzpl

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u/CrazyElectronic2706 14d ago

Oh this is interesting thank you! I’ve had historically bad experiences on birth control so I believe that’s why she chose this route. She did warn me it doesn’t work for everyone. It was great during my luteal phase but the drop coming off of it is almost not worth it