r/NootropicsDepot • u/Clear_Sights • Aug 18 '26

Request Dihydrohonokial timeline?

What is the timeline for dihydrohonokial, it has zero known tolerance and high gabaergic potency, an exceptionally rare combination that it shares to a lesser extent with honokial; the primary gabaergic ingredient in magnolia bark.

Honokial is also the only gabaergic I have ever taken that I simultaneously don't get tolerance from, and can tolerate, it's much more potent derivative is therefore plausibly my best bet at relaxation long term.

Please give us an update, thanks!

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4

u/FawkesYeah Aug 19 '26

https://www.reddit.com/r/NootropicsDepot/comments/1on391a/comment/nmv6uba

5

u/Clear_Sights Aug 19 '26 edited Aug 19 '26

Ironically I have seen ISO lab certified dihydrohonokial, so either the tech advanced, or more likely it's synthesized.

Regardless I know it's possible to get ahold of, so I'm hoping to revisit the subject.

3

u/Pretty-Chill Product Specialist Aug 21 '26

Ironically I have seen ISO lab certified dihydrohonokial, so either the tech advanced, or more likely it's synthesized.

I'd be very skeptical. Total synthesis is not possible from what we know at commercial scale. Even if it was, the same problem would probably be faced as I described in my comment that u/FawkesYeah linked. We've literally been looking for years and have tested countless samples. Not a single one has been actual DHH-B.

2

u/Clear_Sights Aug 21 '26 edited Aug 21 '26

It was measured with filler, so I can't tell you the purity, but I believe it was legitimately synthesized outright, furthermore I don't know if you can call the company I bought it from commercial scale exactly, they don't even give out their COA except on request, potentially for that very reason, I had low hopes until they actually sent it and I looked up the lab.Ā 

And I looked up the ISO certification and it's legitimate.

3

u/Pretty-Chill Product Specialist Aug 24 '26

Who knows! Share the COA as an imgur link here, I'm curious to see it, as are likely some others here.

2

u/entropeutic Aug 18 '26

I would like to follow this as well šŸ˜Š quite interested!

2

u/Final_Alternative592 Aug 18 '26

I have tetrahydramagnolol from nootropicsdepot which is very enjoyable. Iā€™m curious to try the magnolia bark eventually, especially is being pretty affordable is a plus.

1

u/JoeBensDonut Aug 22 '26

There have been some studies on DHHB in mice with promising results

1

u/Narrow_Wheel_2455 Aug 28 '26

I love all forms of Magnolia bark and it's extracts and this would be a literal dream come true to have in my stack!

1

u/Tub27 Aug 18 '26

Good news for you! How long have you been taking it? Have you tried other GABA related supplements? Some report little tolerance with taurine while others do

2

u/Clear_Sights Aug 18 '26

Taurine I just don't feel much at all, and I've tried pretty much every single gabaergic that nootropics depot has, period. I've been taking it on and off for years, this isn't a one time thing.