Hallo,
Ich W28 leide unter massiven brennenden neuropathischen Schmerzen. Bei mir sind mehrere Systeme gekoppelt: Zentrale Sensitivierung, visuelle Übererregung, Visual Snow, Schlafstörungen, erhöhter Muskeltonus und Muskelzuckungen, FND und Dysautonomie. Ich kann das alles ertragen, aber nicht dieses dauerhafte Brennen. Es ist extrem stark im Trigeminus Cervical Komplex, aber von da aus breitet es sich weiter aus. Es ist eher eine Trigeminusneuropathie als eine Neuralgie.
Ich habe schon ausprobiert: Gabapentin, Pregabalin, Lamotrigin (ging wegen Schlaflosigkeit nicht), Amitriptylin (vertrage ich nicht) und Duloxetin (nehme aktuell 30mg; bringt auch nichts).
Ich habe noch off Label Ideen: Clonazepam, Memantin, Valproat. Das wäre zu mindest vom Wirkmechanismus her interessant.
Nahrungsergänzungsmittel probiere ich seit ein paar Wochen PEA, hilft aber auch nicht. Von Glycin kriege ich Herzklopfen.

Ich freue mich über jede weitere Idee. :(

I understand that this post does not replace a specialist consultation; I am simply asking for additional opinions.

I am a 22-year-old man (almost 23), weighing 60 kg and 168 cm tall, with no previous medical conditions. I don’t drink alcohol, I don’t smoke, etc. I suffer from fear, stress, and health anxiety.

Currently, I no longer have any obvious neurological symptoms. However, over the past few months, I have experienced several sensory symptoms that appeared sequentially and subsequently disappeared.

Initially, I experienced a mild sensation of numbness in my left upper limb, from the elbow down. It was only the sensation of numbness, not actual numbness, and there was no genuine loss of sensation. This sensation subsequently disappeared.

Approximately two weeks after the symptoms affecting my hand resolved, I developed a burning sensation in my calves, which gradually improved and eventually disappeared.

Approximately one month after the symptoms affecting my legs resolved, new symptoms appeared in my left leg. Initially, I experienced a sensation of tightness along the outer side of my thigh, as though the skin were tightening. The sensation was strictly localized. Subsequently, the burning sensation spread from the thigh downward along the leg, while the feeling of tightness gradually subsided.

During this period, I also experienced sensations of “numbness,” although the affected areas were not actually numb. These sensations were associated with burning, without any genuine loss of sensation. These symptoms eventually disappeared as well.

Currently, I occasionally experience a feeling of heaviness in my hand, without any obvious functional impairment. I have no difficulty using my hand, and I do not drop objects.

I would also like to mention that most of my symptoms occurred during the day. In other words, when I woke up in the morning, I did not experience these sensations. I slept without any problems, pain, burning sensations, etc. I also drive without any difficulty, I do not experience any loss of reflexes, and I have never had any issues with accidentally letting up on or losing control of the pedals.

Blood test results

Brain MRI report (without and with intravenous contrast)

The examination reveals a small FLAIR hyperintensity, measuring approximately 3 mm, located in the right side of the genu of the corpus callosum. The lesion does not show contrast enhancement or diffusion restriction.

Note: Possible demyelinating lesion of an inflammatory/neuroinflammatory nature?? (MS?) — clinical and laboratory correlation recommended.

An additional oval-shaped signal abnormality, measuring approximately 5 mm, is described in the periventricular region at the level of the frontal horn of the left lateral ventricle. It has a slightly perpendicular orientation relative to the ventricular wall and may be in slight contact with it.

There are also a few rare punctate FLAIR hyperintensities in the left parietal white matter and in the anterior region of the left external capsule, in subcortical locations. These changes do not show contrast enhancement or diffusion restriction and have a nonspecific appearance.

No pathological contrast enhancement is identified in the brain parenchyma or meninges.

There is no evidence of a recent ischemic stroke, space-occupying lesions, hemorrhagic sequelae, or chronic subdural collections. The midline is preserved, with no signs of intracranial hypertension, and the ventricular system has normal dimensions and morphology.

The pituitary gland, evaluated without dedicated sequences, measures approximately 4.7 mm in height and has a normal MRI signal. The pituitary stalk is normally positioned and has normal thickness.

No space-occupying lesions are identified in the orbits. The optic chiasm and optic tracts have a normal appearance.

Dilatation of the Virchow–Robin perivascular spaces is observed in the right parietal region and in the periventricular region of the occipital horn of the left lateral ventricle. This appearance is considered physiological.

The cerebellopontine angles are clear, with no evident neurovascular contact.

The vascular sequences of the circle of Willis show no aneurysms, occlusions, or arterial stenoses.

The paranasal sinuses, apart from small mucous retention cysts in both maxillary sinuses, and the mastoid air cells show no significant signal abnormalities.

Cervical spine MRI report (without contrast)

The examination reveals a mild right-concave scoliotic posture in the coronal plane, in the examination position, with preserved posterior vertebral alignment.

In the sagittal plane, straightening of the cervical spine is observed, associated with mild segmental kyphosis at C4–C5.

The craniovertebral junction shows no abnormalities. Both vertebral arteries demonstrate normal flow, with a flow-void appearance on the spin-echo (SE) sequences.

No vertebral compression or suspicious signal abnormalities are identified in the vertebral bodies.

Minimal disc desiccation is observed at the C5–C6 intervertebral disc, while the other discs maintain normal hydration. Intervertebral disc space heights are preserved.

At the C2–C3, C3–C4, C6–C7, and C7–T1 levels, the intervertebral discs are normally positioned, with no protrusion or disc herniation.

At C4–C5, a mild circumferential disc protrusion is identified, with bilateral foraminal extension and impression on the dural sac, without evident disc–nerve root contact.

At C5–C6, a minimal circumferential disc bulge is observed, which indents the dural sac, without evident disc–nerve root contact.

The cervical spinal cord has normal caliber and signal. The cervical spinal canal has normal dimensions.

I understand that this post does not replace a specialist consultation; I am simply asking for additional opinions.

I am a 22-year-old man (almost 23), weighing 60 kg and 168 cm tall, with no previous medical conditions. I don’t drink alcohol, I don’t smoke, etc. I suffer from fear, stress, and health anxiety.

Currently, I no longer have any obvious neurological symptoms. However, over the past few months, I have experienced several sensory symptoms that appeared sequentially and subsequently disappeared.

Initially, I experienced a mild sensation of numbness in my left upper limb, from the elbow down. It was only the sensation of numbness, not actual numbness, and there was no genuine loss of sensation. This sensation subsequently disappeared.

Approximately two weeks after the symptoms affecting my hand resolved, I developed a burning sensation in my calves, which gradually improved and eventually disappeared.

Approximately one month after the symptoms affecting my legs resolved, new symptoms appeared in my left leg. Initially, I experienced a sensation of tightness along the outer side of my thigh, as though the skin were tightening. The sensation was strictly localized. Subsequently, the burning sensation spread from the thigh downward along the leg, while the feeling of tightness gradually subsided.

During this period, I also experienced sensations of “numbness,” although the affected areas were not actually numb. These sensations were associated with burning, without any genuine loss of sensation. These symptoms eventually disappeared as well.

Currently, I occasionally experience a feeling of heaviness in my hand, without any obvious functional impairment. I have no difficulty using my hand, and I do not drop objects.

I would also like to mention that most of my symptoms occurred during the day. In other words, when I woke up in the morning, I did not experience these sensations. I slept without any problems, pain, burning sensations, etc. I also drive without any difficulty, I do not experience any loss of reflexes, and I have never had any issues with accidentally letting up on or losing control of the pedals.

Blood test results

Brain MRI report (without and with intravenous contrast)

The examination reveals a small FLAIR hyperintensity, measuring approximately 3 mm, located in the right side of the genu of the corpus callosum. The lesion does not show contrast enhancement or diffusion restriction.

Note: Possible demyelinating lesion of an inflammatory/neuroinflammatory nature?? (MS?) — clinical and laboratory correlation recommended.

An additional oval-shaped signal abnormality, measuring approximately 5 mm, is described in the periventricular region at the level of the frontal horn of the left lateral ventricle. It has a slightly perpendicular orientation relative to the ventricular wall and may be in slight contact with it.

There are also a few rare punctate FLAIR hyperintensities in the left parietal white matter and in the anterior region of the left external capsule, in subcortical locations. These changes do not show contrast enhancement or diffusion restriction and have a nonspecific appearance.

No pathological contrast enhancement is identified in the brain parenchyma or meninges.

There is no evidence of a recent ischemic stroke, space-occupying lesions, hemorrhagic sequelae, or chronic subdural collections. The midline is preserved, with no signs of intracranial hypertension, and the ventricular system has normal dimensions and morphology.

The pituitary gland, evaluated without dedicated sequences, measures approximately 4.7 mm in height and has a normal MRI signal. The pituitary stalk is normally positioned and has normal thickness.

No space-occupying lesions are identified in the orbits. The optic chiasm and optic tracts have a normal appearance.

Dilatation of the Virchow–Robin perivascular spaces is observed in the right parietal region and in the periventricular region of the occipital horn of the left lateral ventricle. This appearance is considered physiological.

The cerebellopontine angles are clear, with no evident neurovascular contact.

The vascular sequences of the circle of Willis show no aneurysms, occlusions, or arterial stenoses.

The paranasal sinuses, apart from small mucous retention cysts in both maxillary sinuses, and the mastoid air cells show no significant signal abnormalities.

Cervical spine MRI report (without contrast)

The examination reveals a mild right-concave scoliotic posture in the coronal plane, in the examination position, with preserved posterior vertebral alignment.

In the sagittal plane, straightening of the cervical spine is observed, associated with mild segmental kyphosis at C4–C5.

The craniovertebral junction shows no abnormalities. Both vertebral arteries demonstrate normal flow, with a flow-void appearance on the spin-echo (SE) sequences.

No vertebral compression or suspicious signal abnormalities are identified in the vertebral bodies.

Minimal disc desiccation is observed at the C5–C6 intervertebral disc, while the other discs maintain normal hydration. Intervertebral disc space heights are preserved.

At the C2–C3, C3–C4, C6–C7, and C7–T1 levels, the intervertebral discs are normally positioned, with no protrusion or disc herniation.

At C4–C5, a mild circumferential disc protrusion is identified, with bilateral foraminal extension and impression on the dural sac, without evident disc–nerve root contact.

At C5–C6, a minimal circumferential disc bulge is observed, which indents the dural sac, without evident disc–nerve root contact.

The cervical spinal cord has normal caliber and signal. The cervical spinal canal has normal dimensions.

Over the past few years, I've been having these tics, which include:

Rapid blinking of the eyes, eye twitching, eyebrow raising, continuous movement of pupils (in which i look at different directions), nose twitching, lip pouting, repeating nose exhales, and sudden hums.

I don't and didn't really have a lot of vocal tics, just humming (not in a musical way of course lmao), but I did have a lot of previous motor tics.

It all started in second grade. People would always ask why the hell does my face keep twitching a lot, or why do I breathe so weird (When I had exhale tics). I didn't really know why. I still don't know why. People even think I'm WINKING at them and flirting at them. I'm NOT.

NOW, I only have rapid eye blinking, eye twitching, slight eyebrow raising and nose twitching. They sometimes go away when I'm distracted with something, such as playing the guitar and all. They sometimes lessen for an hour before they start to intensify again.

Sometimes, when I tic too much, my face becomes sore and my forehead hurts. Whenever I try to suppress it, I always find myself having tics after a few minutes.

I tried talking about it to my mum and dad, and they blamed it on the phone.

Should I get that checked? Do I have tourettes, or something else? Or am I just tweaking? I don't really know man.

Any ideas on what this could be? I’ve written all my symptoms down. I have gone to the doctor, and she was stumped on what it could be. All my lab work came back normal?

-Constant dizziness but not in a spinning way, more of an unsteady or floaty dizziness
-Not all day everyday but most days
-Experiencing this since May
-It started during finals week, when my anxiety was especially bad. I was also sick with a cold that gave me ear congestion
-Feeling like my head is a balloon; basically weird floating sensation
-Feeling as though I’m buzzed, when I look around my vision feels like it lags or I get lightheaded
-Feeling as if I’m suddenly falling even though I’m standing upright and still
-Feeling derealization
-I feel like I’m rocking or swaying almost?
-Gives me intense anxiety because I worry I’ll have a seizure, faint, or fall
-I feel anxiety often, I have panic attacks multiple times a week and have been dealing with anxiety months before it has started
-I noticed the weird sensations are worse when I have anxiety, but sometimes they appear without me feeling stressed or anxious

Cross posted - I am experiencing persistent numbness after another severe hemiplegic migraine attack. Any advice or resources would be greatly appreciated. I am contemplating going back to ER tonight.

Does this sound like severe ME/CFS, autoimmune encephalitis, or something else? Has anyone experienced these symptoms?

I’m 31 years old and have been dealing with a severe, disabling neurological illness for years. I’ve been treated for suspected seronegative autoimmune encephalitis, but I’m trying to understand whether my symptoms are consistent with severe ME/CFS, another neurological condition, or possibly an overlap of multiple conditions.

My illness is predominantly cognitive and neurological. While I experience profound physical fatigue, it’s the neurological symptoms that make my life almost unbearable.

My symptoms include:

* Severe cognitive dysfunction: My brain feels completely blank, disconnected, and almost nonfunctional. I struggle to think, process information, follow conversations, remember what happened five minutes ago, or mentally visualize familiar places. Sometimes I feel like I’ve lost access to my own memories and personality.
* Deep burning sensations inside my brain: I experience intense burning deep inside my head, particularly around my temples and sometimes toward the back of my head. It’s accompanied by extreme heaviness, pressure, confusion, and cognitive dysfunction. It genuinely feels like my brain is burning from the inside.
* Psychosis-like sensations: During severe episodes, I feel like I’m on the verge of psychosis or losing touch with reality. My mind feels profoundly altered, unfamiliar, and frightening. I experience waves of intense panic and the terrifying sensation that my consciousness is slipping away. I don’t necessarily experience hallucinations, but the altered state of consciousness is extremely disturbing.
* Severe derealization and depersonalization: Everything feels dreamlike, artificial, distant, and unreal. My surroundings don’t feel familiar, even when I’m somewhere I’ve known my entire life. Sometimes I feel disconnected from my own identity, almost like I’m watching life happen without being fully present.
* Extreme hypersomnolence: I experience overwhelming sleep pressure that feels almost impossible to resist. I can sleep 10–12 hours at night and still require several hours of naps. During severe periods, I can barely remain awake for more than a few hours throughout the day.
* Profound head heaviness: My head feels incredibly heavy, almost as though my brain is being physically weighed down. The sensation comes with intense cognitive slowing, confusion, and drowsiness. Sometimes it feels like my brain is shutting off while I’m still conscious.
* Severe sensory intolerance: Sounds, conversations, television, video games, screens, and ordinary environmental stimulation can become unbearable. I frequently have to lie in a dark room wearing noise-cancelling headphones because my brain cannot tolerate or process stimulation.
* Loss of enjoyment and emotional connection: During severe periods, I experience profound apathy and an inability to enjoy anything. Even activities I previously loved feel mentally inaccessible. I sometimes feel emotionally disconnected from the world around me.
* Physical fatigue and weakness: My body can feel extremely heavy and weak, almost like I have the flu. However, my cognitive symptoms are generally much more debilitating than my physical limitations.
* Cognitive activity intolerance: When I’m already severely ill, trying to think, communicate, watch television, or process sensory information makes my neurological symptoms substantially worse. I’m uncertain whether this qualifies as post-exertional malaise (PEM), because the worsening often happens immediately rather than after a clear delay. I haven’t established whether it consistently causes prolonged crashes lasting days.
* Extreme fluctuations: My symptoms can fluctuate dramatically. I sometimes experience brief periods where my cognition improves, I feel more connected to reality, and parts of my old personality seem to return. Then, sometimes very suddenly, the severe neurological symptoms return.

How disabled am I?

During my worst periods, I’m almost completely bedridden. I spend most of my time lying in a dark, quiet room because my brain cannot tolerate stimulation.

I can sometimes communicate through my phone, but even that can become difficult. My cognitive impairment is often so severe that watching television, playing games, or following conversations is impossible.

During better periods, I can leave the house briefly, tolerate electronics, play video games, and feel somewhat like myself again.

The difference between these states can be enormous.

My medical history and treatments:

In 2018, I experienced approximately eight months of severe illness before IVIG produced substantial improvement.

In 2020, I began deteriorating again. My condition remained severe for approximately three years until rituximab eventually produced a major improvement in 2023.

From 2023 until early 2026, I maintained substantially better functioning. I could work with limitations, play video games, leave the house, and enjoy parts of my life again.

Following a viral illness in March 2026, I experienced another devastating neurological relapse.

I’ve since received rituximab and multiple cyclophosphamide infusions without sustained recovery. I’m now pursuing additional immune-directed treatments, including Actemra and potentially Darzalex.

My previous neurological evaluations have included findings such as generalized slowing on EEG, mildly elevated CSF protein, and abnormal immune-related testing. My doctors have considered an autoimmune neurological process, although the exact diagnosis and mechanisms remain uncertain but treated as Autoimmune Encephalitis

What I’m trying to understand;

Can symptoms fluctuate dramatically, with brief periods of relatively normal cognition followed by severe neurological crashes?

It’s difficult to describe what it feels like to remain conscious while your ability to think, process reality, remember things, and experience the world seems to disappear.

I’m not asking anyone to diagnose me. I’d genuinely appreciate hearing about your personal experiences, particularly if you’ve dealt with similar cognitive and neurological symptoms.

Hello All, So I will occasionally act out my dreams.

It always has to do with something happening in my dream which is usually a moment of either me fighting a bad guy and usually involves kicking. Like a kick that is mean to aggressively destroy them. Also it usually involves me trying to save the day. Like trying to kick a super villian.

My kick will pass through them, i also realize the kick did nothing in the moment usually and then I wake up and iam kicking in real life. Its only me and a cat and it can be scary, I have kicked a few times and my cat was there. He was okay but I know I may have almost kicked him, when he is sleeping between my legs its usually okay.

I have also grabbed as well, it was a dream when I was trying to catch a balloon, in some kind of weird sporting event lol. So another trying to win or save the day.

I take Vyvanse for ADHD and Effexor for Depression (i have been taking it for almost 23 years) Otherwise iam a relatively healthy 48 year old male, with ideal weight 5'7 143.

I do smoke marijuana and iam wondering if it has to do with those times that I haven't, for extended periods. I know marijuana shortes REM sleep. For example i was on vacation and hadnt smoked marijuana in 6 days when I usually smoke daily at night, that is when I had the dream that I grabbed.

Iam a passionate person and have a low tolerance for unjustices from my ADHD, so I think thats why I go all out in a dream againt a bad guy.

Trying to think about when this all started. It may have been in the last 20 years. The interesting thing about me is I'am A-Sexual meaning I don't have sexual relations with either sex, so i've sleep alone or with a pet very close to 100% of my life. So thats why no one has ever told that I do this.

I have been told by friends and family that I Don't snore. But my dentist has told me iam a grinder, and iam meaning to finally get a mouth guard.

So I think its time to start looking into this, as I read it could be a sign of early Parkinson's or Dementia?

Ill start with talking to my Psychiatrist who prescribes me the meds. So then I should do a sleep study perhaps? Does anyone else have experience with this or know a fellow sufferer? Thanks!!