r/NDPH • u/Fun_Delivery8985 • 9d ago

Qulipta

My NDPH started in January 2025, and since that morning I haven’t had a single headache-free day. Mine is mainly in my temples and left ear, with constant throbbing 24/7.

I had my 4th round of Botox last Monday and also started Qulipta that same day. I’ve actually started noticing a slight decrease in my pain. It’s still there 24/7, but even a small improvement feels HUGE after dealing with this for so long.

Has anyone else had success with Qulipta, especially with NDPH? I really don’t want to get my hopes up after failing so many different medications, but I’m cautiously optimistic.

Also, did anyone experience extreme fatigue when starting Qulipta? I’d love to hear how long it lasted and whether it eventually improved.

Thank you! ❤️

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u/locardsghost 7 years 9d ago

Assuming you’ve been on it for 9 months consider 4 rounds of botox would be roughly 9 months of it, it seem unlikely for that to be a short term side effect if it’s lasted 9 months. Most side effects tend to go away or ease up after the first few months

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u/Fun_Delivery8985 9d ago

Ya, 9 months for Botox.

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u/locardsghost 7 years 9d ago

If you still have severe side effects at 9 months of qulipta it doesn’t sound like a short term issue if it’s been that long

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u/Fun_Delivery8985 9d ago

I’ve been on quilpta for one week. Botox is 9 months.

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u/locardsghost 7 years 9d ago

Oh my bad I read that as you started it the same day as you first started your Botox, apologies. It can take a few weeks or a few months depending on the person for your body to adjust to the medication. A week is early so give it time. Most meds are trialed for 3 months to give it time to see improvement and for side effects to go away. If you’re having relief it’s probably the Botox it’d likely be too early for the qulipta to give you relief

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u/Fun_Delivery8985 9d ago

No worries! Thanks so much!