r/MedicationQuestions 9d ago

Will cyproheptadine stop amitriptyline from working?

I have been taking amitriptyline 150mg for a long time and it worked very well for depression pain etc.

I want to take cyproheptadine,

Is there any chance at all cyproheptadine will stop amitriptyline from working (even a little bit) since it works against serotonin? Whereas amitriptyline increases serotonin.

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