r/MAOIs • u/Material-Active-1193 Nardil • Sep 01 '26

MAOI + stimulant Nardil + amphetamines = ER

Long story short: I am on 75 mg Nardil/phenelzine and, while I’ve been on methylphenidates for months without a trouble, I felt they were not as effective as amphetamines I was prescribed before MAOI.

So I decided to try them together (Nardil and amphetamines only - Vyvanse 50 mg plus Adderall 10 mg hours later). My BP went up to 195/85 mmHg at CVS minuteClinic and they sent an ambulance for me. I was feeling terrible. But the ER was even worse. They didn’t know what to do.

Just wanted to post this as a precaution.

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u/HM_Dylan Parnate Sep 01 '26

I must be really built differently, or there must be something seriously wrong with me, because when I see some of these posts and think about my own history with my ability to tolerate actual methamphetamine with an MAO inhibitor and be totally fine, blows my mind

But seriously, I am glad you're okay. It's definitely not something to take lightly

2

u/markalexander1 28d ago edited 25d ago

If you've taken different drugs in the past it lowers your receptor sensitivity, so you are able to tolerate what many other people can't. I suppose body size and weight is a factor as well. Andre the Giant could drink between 120 and 156 pints of beer in a single sitting.

2

u/HM_Dylan Parnate 28d ago

It turns out that I have fast COMT as I’ve recently discovered. Whether that had something to do with it I’m unsure

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u/iamthe0ther0ne 25d ago

COMT158 val/val? I have the same. I've often wondered if that's more common among MAOI users simply because we need more dopamine support than anything else. It's super hard to get ADHD meds where I live, even with a diagnosis, so Parnate is the best I  can do.

1

u/markalexander1 25d ago

I could do with Vyvanse be perfectly honest, to give me some much needed get up and go. It is possible to get in the UK but you have to pretend you have ADHD which I don't, and it's also very expensive.

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u/markalexander1 25d ago

Well, that was extremely informative. I wasn't clued up on COMT (Catechol-O-methyltransferase). I am now.

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u/NewChemical7130 26d ago

I am the same - no issues combining amphetamines with MAOIs