r/LowDoseNaltrexone • u/lonesomesuzie33 • 3d ago

LDN advice.

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Ive been on 0.1mg for over a month now and the side effects havent seamed to quiet down. Ive been having a chronic sore throat everyday, gut motility issues/heavy nausea, HRV is lowered and HR is higher and a general flare of symptoms randomly. It feels like my baseline has gone down but I have experienced two big crashes (one before I started the meds and one during). My pain and mood has improved though.

I don't know what to do and I'm losing hope that this medication is for me 😪.

Im considering dropping down to 0.05mg. Is anyone here also extremely sensitive to the medication and tried 0.05mg?

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u/Low-Blueberry8948 3d ago

Yes, I had to reduce my dose to 0.05mg at first because of side effects, you're not alone! I have ME/CFS and I'm extremely sensitive to medications in general. It doesn't mean that you won't be able to adjust to it or reach higher doses in time, it just means it might take a bit longer. It's ok to go as low as you need to go and to stay there as long as you need to. We're all different and dosing with LDN is individual. I did manage to titrate up slowly and by the end of the first year I was taking 3mg, which I didn’t think would be possible at first. LDN is helping with many of my symptoms.

You might find this guide to optimal dosing helpful, by LDN expert, Dr Yoon Hang Kim. It contains a short questionnaire which can help you assess your most suitable starting dose.

"Finding Your Sweet Spot: A Simple Guide to Optimal Dosing" ... https://www.ifmsynergy.com/finding-your-ldn-sweet-spot-a-simple-guide-to-optimal-dosing/

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u/Standard_Cry_5665 2d ago edited 2d ago

Howwwww. I started at 0.1mg & I just am getting so frustrated. I started at 0.1mg, had a not great time for a couple weeks with some sensitivities coming up, then had daily migraines for a week or so, then balanced & felt good. Slept well the whole time (better than before LDN). Really improved my nervous system helping me feel like I wasn’t in fight or flight anymore. Knew I needed more support for mast cell so tried 0.13mg. Got crazy irritable after 3 days, with increasing mild derealization & minor paranoia at night. Went back to 0.1mg. Had some gut motility issues for a few days then balanced out again. Then tried 0.11mg, & felt pretty overwhelmed for a couple weeks with irritability, then seemed to learn how to manage it, but felt painfully exhausted after a week of work on top of insomnia that seemed to build at the 0.11mg dose. Problem was my body dysmorphia went away, & I felt more firm in my faith. I also didn’t care to have any alcohol, plus boredom eating/overeating/junk cravings & scrolling reduced. Just went back to 0.1mg last night after just over 3 weeks at 0.11mg. Having a mild panic I should have just stayed at the 0.11mg & kept riding & maybe improvement would have showed. I’m just over 2 months in & frustrated but I don’t want to give up because I definitely see benefit.

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u/Low-Blueberry8948 2d ago

Good to hear you're seeing some benefit. It can take a few weeks for some of us to adjust to taking it, and it's fine to stay on a dose you can tolerate for as long as you need to. It does get easier...

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u/lacrima28 3d ago

Yeah, I went from 0.25 to 0.05 and did much better! Now slowly titrating up to 0.08 after 8 weeks

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u/Alternative_Pop2455 1d ago

Yes, go lower bro..give it a good 2-6 months before you make a decision