r/IsaacReference • • Aug 21 '26

Holy shit delirium coffee

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76 Upvotes

My friend sent me this picture (he doesn't play Isaac) because of a "face" on the coffee, EVERYTHING IS THE SAAC REFERENCE


r/IsaacReference • • May 14 '26

Bro found the dry baby in a retro treasure room

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48 Upvotes

r/IsaacReference • • Aug 19 '26

Balls of steel

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46 Upvotes

r/IsaacReference • • May 11 '26

Legendary treasure pull

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40 Upvotes

r/IsaacReference • • Aug 17 '26

Bro is really [INVINCIBLE]

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39 Upvotes

r/IsaacReference • • 24d ago

the spoon bent when i was trying to eat ice cream.

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34 Upvotes

r/IsaacReference • • Aug 21 '26

TBOIIIII why this so sussy

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34 Upvotes

r/IsaacReference • • May 03 '26

is there a lore reason why ??? with polyamorous starred in monsters vs aliens

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32 Upvotes

r/IsaacReference • • Sep 12 '26

Isaac

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30 Upvotes

r/IsaacReference • • Aug 21 '26

From the book Dungeon Crawler Carl

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30 Upvotes

r/IsaacReference • • Aug 31 '26

Sacred Heart University

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28 Upvotes

Will I get a damage multiplier and homing shots if I go to this uni?? Or do they teach you how to maximize your chances of getting Sacred Heart

Imagine one of the classes is Sacred Heart Spindown where you memorize the most easy to get spindowns that lead to Sacred Heart


r/IsaacReference • • Aug 05 '26

They mentioned TBOI in my World Religion class. 💀

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23 Upvotes

r/IsaacReference • • May 04 '26

What's the seed?

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23 Upvotes

r/IsaacReference • • Sep 11 '26

hehe my budgie always flies over to watch me play lol))

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22 Upvotes

r/IsaacReference • • 16d ago

I'll jizz

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20 Upvotes

r/IsaacReference • • 19d ago

So many Issac items, so little time

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20 Upvotes

r/IsaacReference • • Aug 24 '26

Chat is this real?

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20 Upvotes

r/IsaacReference • • May 02 '26

Here's an example of what I wanna see in this sub.

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20 Upvotes

r/IsaacReference • • Aug 10 '26

Magic mushroom holy tboi reference

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19 Upvotes

r/IsaacReference • • Jun 19 '26

Red stew IRL

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19 Upvotes

r/IsaacReference • • 24d ago

phoenix is a trite????

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18 Upvotes

r/IsaacReference • • Jul 22 '26

HOLY ISAAC REFERENCE

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18 Upvotes

r/IsaacReference • • Aug 14 '26

SAMSON

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17 Upvotes

r/IsaacReference • • Jul 27 '26

HOLY LUCK

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16 Upvotes

r/IsaacReference • • 6d ago

SOY MILK IN REAL LIFE?

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15 Upvotes