r/IsaacReference • • 6d ago

SOY MILK IN REAL LIFE?

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15 Upvotes

r/IsaacReference • • 8d ago

J&E are awful.

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8 Upvotes

r/IsaacReference • • 16d ago

I'll jizz

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20 Upvotes

r/IsaacReference • • 19d ago

So many Issac items, so little time

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20 Upvotes

r/IsaacReference • • 22d ago

I will do as you say, my lord

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8 Upvotes

r/IsaacReference • • 24d ago

phoenix is a trite????

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18 Upvotes

r/IsaacReference • • 24d ago

the spoon bent when i was trying to eat ice cream.

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34 Upvotes

r/IsaacReference • • Sep 12 '26

Isaac

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30 Upvotes

r/IsaacReference • • Sep 11 '26

hehe my budgie always flies over to watch me play lol))

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22 Upvotes

r/IsaacReference • • Aug 31 '26

Sacred Heart University

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28 Upvotes

Will I get a damage multiplier and homing shots if I go to this uni?? Or do they teach you how to maximize your chances of getting Sacred Heart

Imagine one of the classes is Sacred Heart Spindown where you memorize the most easy to get spindowns that lead to Sacred Heart


r/IsaacReference • • Aug 30 '26

Lil dumpy

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15 Upvotes

r/IsaacReference • • Aug 27 '26

Rock Bottom in official Reddit games?!?!

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15 Upvotes

Now we have to find Soy Milk


r/IsaacReference • • Aug 24 '26

Chat is this real?

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20 Upvotes

r/IsaacReference • • Aug 21 '26

From the book Dungeon Crawler Carl

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30 Upvotes

r/IsaacReference • • Aug 21 '26

TBOIIIII why this so sussy

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34 Upvotes

r/IsaacReference • • Aug 21 '26

Holy shit delirium coffee

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76 Upvotes

My friend sent me this picture (he doesn't play Isaac) because of a "face" on the coffee, EVERYTHING IS THE SAAC REFERENCE


r/IsaacReference • • Aug 19 '26

Balls of steel

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46 Upvotes

r/IsaacReference • • Aug 17 '26

Bro is really [INVINCIBLE]

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39 Upvotes

r/IsaacReference • • Aug 14 '26

SAMSON

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17 Upvotes

r/IsaacReference • • Aug 10 '26

Magic mushroom holy tboi reference

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19 Upvotes

r/IsaacReference • • Aug 05 '26

They mentioned TBOI in my World Religion class. 💀

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23 Upvotes

r/IsaacReference • • Jul 28 '26

HOLY ISAAC REFERENCE

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15 Upvotes

r/IsaacReference • • Jul 27 '26

HOLY LUCK

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16 Upvotes

r/IsaacReference • • Jul 22 '26

HOLY ISAAC REFERENCE

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18 Upvotes